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    Arginine inactivation of viruses
    1.
    发明授权
    Arginine inactivation of viruses 有权
    精氨酸灭活病毒

    公开(公告)号：US08980610B2

    公开(公告)日：2015-03-17

    申请号：US13130540

    申请日：2009-11-20

    申请人： Keith Selvitelli ,  Justin McCue

    发明人： Keith Selvitelli ,  Justin McCue

    IPC分类号： C12N7/06 ,  C12N7/00 ,  A61K39/21

    CPC分类号： C12N7/00 ,  A61K39/21 ,  A61K39/245 ,  C07K1/14 ,  C07K14/005 ,  C12N7/06 ,  C12N2710/16063 ,  C12N2710/16763 ,  C12N2740/13063

    摘要： The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH ˜7) or near neutral (˜pH 6 to ˜pH 8) environment.

    摘要翻译： 本发明涉及使用精氨酸灭活或降低可能存在于由真核细胞（例如抗体或其它治疗性蛋白质）产生的生物组合物中的包膜病毒的感染滴度的方法。 在一些实施方案中，通过暴露于精氨酸的病毒滴度的灭活或还原在中性（pH〜7）或接近中性（〜pH 6〜〜8H）环境中实现。

    Arginine Inactivation of Viruses
    3.
    发明申请
    Arginine Inactivation of Viruses 有权
    精氨酸灭活病毒

    公开(公告)号：US20120015424A1

    公开(公告)日：2012-01-19

    申请号：US13130540

    申请日：2009-11-20

    申请人： Keith Selvitelli ,  Justin McCue

    发明人： Keith Selvitelli ,  Justin McCue

    IPC分类号： C12N7/06 ,  C07K16/00

    CPC分类号： C12N7/00 ,  A61K39/21 ,  A61K39/245 ,  C07K1/14 ,  C07K14/005 ,  C12N7/06 ,  C12N2710/16063 ,  C12N2710/16763 ,  C12N2740/13063

    摘要： The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH ˜7) or near neutral (˜pH 6 to ˜pH 8) environment.

    摘要翻译： 本发明涉及使用精氨酸灭活或降低可能存在于由真核细胞（例如抗体或其它治疗性蛋白质）产生的生物组合物中的包膜病毒的感染滴度的方法。 在一些实施方案中，通过暴露于精氨酸的病毒滴度的灭活或还原在中性（pH〜7）或接近中性（〜pH 6〜〜8H）环境中实现。

    ARGININE INACTIVATION OF VIRUSES
    4.
    发明申请
    ARGININE INACTIVATION OF VIRUSES 审中-公开
    ARGININE灭活病毒

    公开(公告)号：US20160010063A1

    公开(公告)日：2016-01-14

    申请号：US14659409

    申请日：2015-03-16

    申请人： BIOGEN MA INC.

    发明人： Keith SELVITELLI ,  Justin MCCUE

    IPC分类号： C12N7/00 ,  C07K1/14

    CPC分类号： C12N7/00 ,  A61K39/21 ,  A61K39/245 ,  C07K1/14 ,  C07K14/005 ,  C12N7/06 ,  C12N2710/16063 ,  C12N2710/16763 ,  C12N2740/13063

    摘要： The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH˜7) or near neutral (˜pH 6 to ˜pH 8) environment.

    摘要翻译： 本发明涉及使用精氨酸灭活或降低可能存在于由真核细胞（例如抗体或其它治疗性蛋白质）产生的生物组合物中的包膜病毒的感染滴度的方法。 在一些实施方案中，通过暴露于精氨酸的病毒滴度的失活或降低在中性（pH〜7）或接近中性（〜pH 6〜〜8H）环境中实现。

    Viral inactivation methods for continuous manufacturing of antibodies
    7.
    发明授权
    Viral inactivation methods for continuous manufacturing of antibodies 有权

    公开(公告)号：US12123028B2

    公开(公告)日：2024-10-22

    申请号：US17292652

    申请日：2019-11-14

    申请人： Bayer HealthCare LLC

    发明人： Shengjiang Liu ,  June Xiaojun Zou ,  Janice Hsiu Mei Lee

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  C12N2740/13063

    摘要： This disclosure relates to methods for use in inactivating viruses. The virus inactivation methods are for use in continuous process manufacturing of a biologic such as an antibody, and include separating an eluate using a column, subjecting said eluate to an orthogonal treatment of low pH and detergent simultaneously wherein, the time for viral inactivation is reduced. In addition, the detergent can be added to buffer system in purification process to achieve the same effect. The biologic in each treatment case is retained.

    Viral clearance by low pH hold
    10.
    发明授权
    Viral clearance by low pH hold 有权

    公开(公告)号：US12077782B2

    公开(公告)日：2024-09-03

    申请号：US17317602

    申请日：2021-05-11

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： Jena Daya ,  Valerie Ann Cusick ,  John Mattila

    IPC分类号： C12N7/00 ,  C07K1/14 ,  C07K16/10

    CPC分类号： C12N7/00 ,  C07K1/14 ,  C07K16/1036 ,  C12N2740/13063

    摘要： Methods for viral clearance using low pH hold based on a statistical design of experiment are provided. Several factors are evaluated to characterize the impacts of a low pH hold step for virus inactivation, including the factors of pH conditions, conductivity conditions, protein type, temperature, acid titrant, spike timing, and post-spike filtration. In addition to the effect of pH on virus inactivation, an increase in ionic strength through manipulating the conductivity can be a key component that influences virus inactivation kinetics.