公开(公告)号：US09999217B2

公开(公告)日：2018-06-19

申请号：US15164531

申请日：2016-05-25

申请人： Biomatrica, Inc.

发明人： Scott E. Whitney ,  Steven Wilkinson ,  Rolf Muller

IPC分类号： C12N5/071 ,  A01N1/02 ,  C12Q1/68

CPC分类号： A01N1/021 ,  C12Q1/6806 ,  C12Q2527/125

摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.

公开(公告)号：US20160338342A1

公开(公告)日：2016-11-24

申请号：US15164531

申请日：2016-05-25

申请人： Biomatrica, Inc.

发明人： Scott E. Whitney ,  Steven Wilkinson ,  Rolf Muller

IPC分类号： A01N1/02 ,  C12Q1/68

CPC分类号： A01N1/021 ,  C12Q1/6806 ,  C12Q2527/125

摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.

摘要翻译： 公开了与本文公开的储存组合物混合后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，其允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以以几个月，几个月或几年的形式储存，而不会在保存期后允许回收完整的DNA，RNA或蛋白质组分。

公开(公告)号：US09725703B2

公开(公告)日：2017-08-08

申请号：US14654457

申请日：2013-12-20

申请人： BIOMATRICA, INC.

发明人： Scott E. Whitney ,  Stephanie De Los Rios ,  Senait Ghirmai ,  Rolf Muller ,  Vasco Liberal ,  Steven P. Wilkinson

IPC分类号： C12N9/12 ,  C12N9/96 ,  C12Q1/68

CPC分类号： C12N9/1252 ,  C12N9/1247 ,  C12N9/96 ,  C12Q1/686 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Q2521/101 ,  C12Q2527/125 ,  C12Q2563/137

摘要： Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.