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1.发明授权公开(公告)号：US11286528B2
公开(公告)日：2022-03-29
申请号：US16246225
申请日：2019-01-11
IPC分类号： C07K14/755 , C12Q1/6883 , A61K38/21 , A61K39/00 , A61K38/37 , A61K47/68
摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.
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2.发明授权公开(公告)号：US10221455B2
公开(公告)日：2019-03-05
申请号：US14371931
申请日：2013-01-12
IPC分类号： C07K14/755 , C12Q1/6883 , A61K38/37 , A61K38/21 , A61K39/00 , A61K47/68
摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.
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3.发明申请公开(公告)号：US20190241960A1
公开(公告)日：2019-08-08
申请号：US16246225
申请日：2019-01-11
IPC分类号： C12Q1/6883 , C07K14/755 , A61K47/68 , A61K39/00 , A61K38/21 , A61K38/37
CPC分类号： C12Q1/6883 , A61K38/21 , A61K38/37 , A61K39/0008 , A61K47/6811 , A61K47/6815 , A61K2039/6031 , A61K2039/6056 , C07K14/755 , C07K2319/30 , C12Q2600/156 , A61K2300/00
摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.
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4.发明申请METHODS OF REDUCING IMMUNOGENICITY AGAINST FACTOR VIII IN INDIVIDUALS UNDERGOING FACTOR VIII THERAPY 审中-公开降低因子VIII治疗个体因子VIII的免疫原性的方法公开(公告)号：US20140370035A1
公开(公告)日：2014-12-18
申请号：US14371931
申请日：2013-01-12
CPC分类号： C12Q1/6883 , A61K38/21 , A61K38/37 , A61K39/0008 , A61K47/6811 , A61K47/6815 , A61K2039/6031 , A61K2039/6056 , C07K14/755 , C07K2319/30 , C12Q2600/156 , A61K2300/00
摘要： The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.
摘要翻译： 本公开提供了将具有FVIII和Fc的嵌合和杂合因子VIII（FVIII）多肽施用于具有发展抑制性FVIII免疫应答风险的受试者的方法，所述风险包括抗FVIII抗体和/或细胞介导的免疫。 该施用足以促进凝血并诱导对FVIII的免疫耐受。 嵌合多肽可以包含全长FVIII或含有缺失的FVIII多肽，例如B结构域的完整或部分缺失。
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公开(公告)号：US11193116B2
公开(公告)日：2021-12-07
申请号：US15619196
申请日：2017-06-09
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang , Mark Brader
IPC分类号： A61K38/36 , C12N9/64 , C07K14/745 , C07K16/36 , A61K38/00
摘要： The present invention provides methods of administering long-acting Factor IX; methods of administering long-acting, chimeric and hybrid polypeptides comprising Factor IX; and methods of producing such chimeric and hybrid polypeptides using cells.
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公开(公告)号：US10561714B2
公开(公告)日：2020-02-18
申请号：US15890284
申请日：2018-02-06
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K38/36 , A61K38/48 , A61K47/64 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61P7/04
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US10548954B2
公开(公告)日：2020-02-04
申请号：US16271689
申请日：2019-02-08
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K38/36 , A61K38/48 , A61K47/64 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61P7/04
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20190192640A1
公开(公告)日：2019-06-27
申请号：US16271686
申请日：2019-02-08
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K38/48 , A61K47/64 , C12N9/96 , C12N9/64 , C07K16/18 , A61K39/395 , A61K38/38 , C07K14/76 , A61K9/00
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US10568943B2
公开(公告)日：2020-02-25
申请号：US16271686
申请日：2019-02-08
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K38/36 , A61K38/48 , A61K47/64 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61P7/04
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US09867873B2
公开(公告)日：2018-01-16
申请号：US14982934
申请日：2015-12-29
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： C07K14/755 , A61K38/48 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61K47/48
CPC分类号： A61K38/4846 , A61K9/0019 , A61K38/38 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K47/643 , C07K14/76 , C07K16/18 , C07K2317/21 , C07K2317/90 , C07K2317/94 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C12N9/644 , C12N9/96 , C12Y304/21022
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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