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公开(公告)号：US11193116B2
公开(公告)日：2021-12-07
申请号：US15619196
申请日：2017-06-09
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang , Mark Brader
IPC: A61K38/36 , C12N9/64 , C07K14/745 , C07K16/36 , A61K38/00
Abstract: The present invention provides methods of administering long-acting Factor IX; methods of administering long-acting, chimeric and hybrid polypeptides comprising Factor IX; and methods of producing such chimeric and hybrid polypeptides using cells.
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公开(公告)号：US11168316B2
公开(公告)日：2021-11-09
申请号：US16228144
申请日：2018-12-20
Applicant: Bioverativ Therapeutics Inc.
Inventor： Joe Salas , Elena Kistanova , Vu Phong Hong , Adam R. Mezo , Robert T. Peters
Abstract: The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors.
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公开(公告)号：US11084866B2
公开(公告)日：2021-08-10
申请号：US15465319
申请日：2017-03-21
Applicant: Bioverativ Therapeutics Inc.
Inventor： Robert T. Peters , Adam R. Mezo , Daniel S. Rivera , Alan J. Bitonti , Susan C. Low
IPC: C07K19/00 , A61K39/00 , C07K14/755 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/745 , C07K16/00 , C12N9/64 , A61K47/68 , C07K14/565 , C12N9/96 , A61K47/60 , C07K14/59 , C07K14/61 , C07K14/705 , A61K47/64 , A61K38/00
Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US10561714B2
公开(公告)日：2020-02-18
申请号：US15890284
申请日：2018-02-06
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC: A61K38/36 , A61K38/48 , A61K47/64 , A61K39/395 , C12N9/96 , A61K38/38 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , A61P7/04
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US10370431B2
公开(公告)日：2019-08-06
申请号：US14767425
申请日：2014-02-14
Applicant: Bioverativ Therapeutics Inc.
Inventor： Siyuan Tan , Robert T. Peters
IPC: C07K14/755 , C12N9/64
Abstract: The present invention provides codon optimized Factor VIII sequences, vectors and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides.
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Patent Agency Ranking
公开(公告)号：US10202595B2
公开(公告)日：2019-02-12
申请号：US14406160
申请日：2013-06-07
Applicant: Bioverativ Therapeutics Inc.
Inventor： Joe Salas , Elena Kistanova , Vu Phong Hong , Adam R. Meso , Robert T. Peters
Abstract: The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors.
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公开(公告)号：US11225650B2
公开(公告)日：2022-01-18
申请号：US15619196
申请日：2017-06-09
Applicant: Bioverativ Therapeutics Inc.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang , Mark Brader
IPC: A61K38/36 , C12N9/64 , C07K14/745 , C07K16/36 , A61K38/00
Abstract: The present invention provides methods of administering long-acting Factor IX; methods of administering long-acting, chimeric and hybrid polypeptides comprising Factor IX; and methods of producing such chimeric and hybrid polypeptides using cells.
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公开(公告)号：US10898554B1
公开(公告)日：2021-01-26
申请号：US17032354
申请日：2020-09-25
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC: A61K38/36 , A61K38/48 , A61P7/04 , A61K47/64 , A61K38/38 , A61K39/395 , C07K16/18 , C12N9/64 , C07K14/76 , A61K9/00 , C12N9/96
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US10881742B2
公开(公告)日：2021-01-05
申请号：US15991629
申请日：2018-05-29
Applicant: Bioverativ Therapeutics Inc.
Inventor： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert T. Peters
IPC: A61K38/37 , A61K47/68 , A61K47/60 , C07K14/755 , G01N33/86
Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20190192641A1
公开(公告)日：2019-06-27
申请号：US16271689
申请日：2019-02-08
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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