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公开(公告)号：US07521465B2
公开(公告)日：2009-04-21
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译： 提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。
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公开(公告)号：US07521466B2
公开(公告)日：2009-04-21
申请号：US11429015
申请日：2006-05-04
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
IPC分类号： A01N43/82 , C07D277/00
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
摘要翻译： 新型二肽醚可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平。 二肽醚也可用于治疗和/或预防糖尿病，肥胖，炎症和自身免疫性疾病如多发性硬化和类风湿性关节炎。
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公开(公告)号：US07087576B2
公开(公告)日：2006-08-08
申请号：US10681827
申请日：2003-10-07
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
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