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    3'-N-Substituted-3-O-Substituted Erythronolide a Derivatives
    1.
    发明申请
    3'-N-Substituted-3-O-Substituted Erythronolide a Derivatives 审中-公开
    3'-N-取代的3-O-取代的红霉素衍生物

    公开(公告)号：US20070270484A1

    公开(公告)日：2007-11-22

    申请号：US10573275

    申请日：2003-09-25

    申请人： Biswajit Das ,  Mohammad Salman ,  Sachin Shelke ,  Atul Hajare ,  Sanjay Talukdar ,  Sujata Rathy ,  Arani Pal ,  Ashok Rattan

    发明人： Biswajit Das ,  Mohammad Salman ,  Sachin Shelke ,  Atul Hajare ,  Sanjay Talukdar ,  Sujata Rathy ,  Arani Pal ,  Ashok Rattan

    IPC分类号： A61K31/7048 ,  A61P31/04 ,  C07H17/08

    CPC分类号： A61K31/7048 ,  Y02A50/473

    摘要： This invention generally relates to macrolides, more particularly, the invention relates to 3-N-substituted-3-O-substituted erythronolide A derivatives, which are antibacterial agents effective against gram positive or gram negative bacteria and atypical pathogens. The compounds of this invention are more particularly effective against Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating bacterial infection.

    摘要翻译： 本发明一般涉及大环内酯类，更具体地说，本发明涉及3-N-取代-3-O-取代的红景天苷A衍生物，它们是对革兰氏阳性或革兰氏阴性细菌和非典型病原体有效的抗菌剂。 本发明的化合物对金黄色葡萄球菌，肺炎链球菌，粪肠球菌，大肠杆菌，铜绿假单胞菌，流感嗜血杆菌更为特别有效。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和治疗细菌感染的方法。

    Antibacterial Agents
    3.
    发明申请
    Antibacterial Agents 审中-公开
    抗菌剂

    公开(公告)号：US20080318878A1

    公开(公告)日：2008-12-25

    申请号：US11576033

    申请日：2005-09-27

    申请人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

    发明人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

    IPC分类号： A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

    摘要翻译： 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属（Chlamydia spp。 ，支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

    Oxazolidinone derivatives as antimicrobials
    4.
    发明授权
    Oxazolidinone derivatives as antimicrobials 失效
    恶唑烷酮衍生物作为抗微生物剂

    公开(公告)号：US07592335B2

    公开(公告)日：2009-09-22

    申请号：US11911576

    申请日：2006-04-12

    申请人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    发明人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    IPC分类号： C07D498/04 ,  A61K31/5383

    CPC分类号： Y02A50/478 ,  Y02P20/55

    摘要： Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    摘要翻译： 本文提供了新的取代的苯基恶唑烷酮，以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌 ，以及厌氧生物，如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。

    Oxazolidinone Derivatives as Antimicrobials
    5.
    发明申请
    Oxazolidinone Derivatives as Antimicrobials 失效
    恶唑烷酮衍生物作为抗菌剂

    公开(公告)号：US20080188470A1

    公开(公告)日：2008-08-07

    申请号：US11911576

    申请日：2006-04-12

    申请人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    发明人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    IPC分类号： A61K31/5383 ,  C07D498/04 ,  A61P31/04

    CPC分类号： Y02A50/478 ,  Y02P20/55

    摘要： Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    摘要翻译： 本文提供了新的取代的苯基恶唑烷酮，以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌 ，以及厌氧生物，如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。

    Oxazolidinone derivatives as antimicrobials
    8.
    发明授权
    Oxazolidinone derivatives as antimicrobials 失效
    恶唑烷酮衍生物作为抗微生物剂

    公开(公告)号：US06734307B2

    公开(公告)日：2004-05-11

    申请号：US09906215

    申请日：2001-07-16

    申请人： Anita Mehta ,  Arora K. Sudershan ,  Biswajit Das ,  Abhijit Ray ,  Sonali Rudra ,  Ashok Rattan

    发明人： Anita Mehta ,  Arora K. Sudershan ,  Biswajit Das ,  Abhijit Ray ,  Sonali Rudra ,  Ashok Rattan

    IPC分类号： C07D41314

    CPC分类号： C07D413/10 ,  C07D413/12 ,  C07D413/14

    摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    摘要翻译： 本发明涉及某些取代的苯基恶唑烷酮及其合成方法。 本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。 这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

    Plymorphic forms of phenyl oxazolidinone derivatives
    10.
    发明申请
    Plymorphic forms of phenyl oxazolidinone derivatives 审中-公开
    苯基恶唑烷酮衍生物的多晶型

    公开(公告)号：US20050209248A1

    公开(公告)日：2005-09-22

    申请号：US10514074

    申请日：2003-05-15

    申请人： Biswajit Das ,  Anita Mehta ,  Ashok Rattan

    发明人： Biswajit Das ,  Anita Mehta ,  Ashok Rattan

    IPC分类号： A61K31/496 ,  A61P31/00 ,  A61P31/04 ,  C07D413/12 ,  C07D413/14

    CPC分类号： C07D413/12

    摘要： The invention relates to phenyl oxazolidinone derivatives. More particularly, it relates to polymorphic forms of (S)-N-[[3-fluoro-4-[N-1[4-{2-furyl-(5-nitro)methyl}]piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide hydrochloride having the Formula I. Further, the invention relates to methods of using such compounds as antimicrobials, pharmaceutical compositions containing the novel polymorphic forms, and processes for the preparation of the polymorphic forms.

    摘要翻译： 本发明涉及苯基恶唑烷酮衍生物。 更具体地说，它涉及（S）-N - [[3-氟-4- [N-1 [4- {2-呋喃基 - （5-硝基）甲基}]哌嗪基] - 苯基] -2 - 氧代-5-恶唑烷基]甲基]乙酰胺盐酸盐。此外，本发明涉及使用这些化合物作为抗微生物剂的方法，含有新型多晶型物的药物组合物，以及制备多晶型物的方法。