利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

72 条记录 (耗时 0.04 秒)

    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER
    6.
    发明申请
    TETRAHYDROPYRIDOTHIOPHENES FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER 审中-公开
    用于治疗增殖性疾病（如癌症）的四氢呋喃半胱氨酸

    公开(公告)号：US20090227577A1

    公开(公告)日：2009-09-10

    申请号：US12411486

    申请日：2009-03-26

    申请人： Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

    发明人： Klaus PEKARI ,  Mathias Schmidt ,  Thomas Bar ,  Thomas Beckers ,  Bjorn Bartels

    IPC分类号： A61K31/4365 ,  A61P25/00 ,  A61K31/506 ,  A61K31/5377

    CPC分类号： C07D495/04

    摘要： The invention relates to compounds of formula I, wherein Ra is —C(O)ORI, in which R1 is 1-7C-alkyl, 3-7C-cycloalkyl, or 1-7C-alkyl substituted by one to four substituents independently selected from R2, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and either Q is optionally substituted by Rba and/or Rbb and/or Rbc, and is phenyl or naphthyl, or Q is optionally substituted by Rca and/or Rcb, and is Has, or Q is optionally substituted by Rda and/or Rdb, and is Het, or Q is optionally substituted by Rea and/or Reb, and is 3-7C-cycloalkyl, which are useful for the therapy of hyperproliferative diseases, in particular human cancer.

    摘要翻译： 本发明涉及式I化合物，其中R a为-C（O）ORI，其中R 1为1-7C-烷基，3-7C-环烷基或被一至四个取代基取代的1-7C-烷基，所述取代基独立地选自 R2，Rb是-TQ，其中T是1-6C-亚烷基或3-7C-亚环烷基，并且Q任选地被Rba和/或Rbb和/或Rbc取代，并且是苯基或萘基，或Q是任选的 被Rca和/或Rcb取代，并且是或者是Q被Rda和/或Rdb任选取代，并且是Het，或Q任选地被Rea和/或Reb取代，并且是3-7C-环烷基，它们是 可用于治疗过度增殖性疾病，特别是人类癌症。