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公开(公告)号:US08273890B2
公开(公告)日:2012-09-25
申请号:US12667093
申请日:2008-06-26
申请人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
发明人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/44
CPC分类号: C07D471/04
摘要: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
摘要翻译: 本发明涉及式(I)的噻吩 - 咪唑并吡啶化合物,其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
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公开(公告)号:US20100278833A1
公开(公告)日:2010-11-04
申请号:US12667093
申请日:2008-06-26
申请人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beata Schmidt , Florian Dehmel
发明人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beata Schmidt , Florian Dehmel
IPC分类号: A61K39/395 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/497 , A61K33/24 , A61P35/00
CPC分类号: C07D471/04
摘要: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
摘要翻译: 本发明涉及式(I)的噻吩 - 咪唑并吡啶化合物,其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
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公开(公告)号:US20110044938A1
公开(公告)日:2011-02-24
申请号:US12377539
申请日:2007-08-15
申请人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
发明人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
IPC分类号: A61K31/381 , C07D409/14 , C07D409/12 , C07D333/68 , C07D413/12 , C07D413/14 , A61K31/444 , A61K31/4436 , A61K31/5377 , A61K31/4178 , A61K31/4545 , A61K31/661 , A61K31/675 , A61K33/24 , A61K31/437 , A61K31/704 , A61K31/513 , A61K31/44 , A61K31/404 , A61K31/517 , A61K39/395 , A61K38/20 , A61P35/00 , A61P35/02
CPC分类号: C07D333/68 , C07D409/12 , C07D409/14
摘要: Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式I化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20100285149A1
公开(公告)日:2010-11-11
申请号:US12377475
申请日:2007-08-15
申请人: Klaus Pekari , Mathias Schmidt , Astrid Zimmermann , Volker Gekeler , Thomas Beckers , Thomas Bär
发明人: Klaus Pekari , Mathias Schmidt , Astrid Zimmermann , Volker Gekeler , Thomas Beckers , Thomas Bär
IPC分类号: A61K33/24 , A61K31/5377 , A61K31/4365 , C07D413/14 , C07D495/04 , A61P35/02 , A61P35/00
CPC分类号: C07D495/04
摘要: Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式I化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US07714136B2
公开(公告)日:2010-05-11
申请号:US11920572
申请日:2006-05-24
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
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公开(公告)号:US07763728B2
公开(公告)日:2010-07-27
申请号:US11920501
申请日:2006-05-24
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bär , Thomas Beckers , Petra Gimmnich
IPC分类号: C07D471/02
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20090257977A1
公开(公告)日:2009-10-15
申请号:US12412484
申请日:2009-03-27
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号: A61K38/20 , C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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8.
公开(公告)号:US20080125452A1
公开(公告)日:2008-05-29
申请号:US11795762
申请日:2006-01-26
申请人: Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
发明人: Matthias Vennemann , Thomas Bar , Jurgen Braunger , Petra Gimmnich , Thomas Beckers , Mathias Schmidt , Thomas Ciossek , Sandra Nappe
IPC分类号: A61K31/4745 , C07D491/14 , C07D498/14 , C07D487/14
CPC分类号: C07D471/14 , C07D491/14 , C07D495/14
摘要: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5 and X have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和X具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和/或凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20080206258A1
公开(公告)日:2008-08-28
申请号:US11920572
申请日:2006-05-24
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号: A61K31/437 , C07D471/04 , A61K31/5377 , A61P35/00 , A61K39/395 , C07D413/14
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式(I)的化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US20080260749A1
公开(公告)日:2008-10-23
申请号:US11920501
申请日:2006-05-24
申请人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
发明人: Klaus Pekari , Mathias Schmidt , Thomas Bar , Thomas Beckers , Petra Gimmnich
IPC分类号: A61K31/4365 , A61P35/00 , A61K31/444 , A61K39/395 , A61K31/70 , A61K31/4439 , C07D495/04
CPC分类号: C07D495/04
摘要: Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
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