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    Derivatives of amino-ascorbic acid, the processes for their preparation and use
    1.
    发明授权
    Derivatives of amino-ascorbic acid, the processes for their preparation and use 失效
    氨基抗坏血酸的衍生物，其制备和使用的过程

    公开(公告)号：US5610181A

    公开(公告)日：1997-03-11

    申请号：US529394

    申请日：1995-09-18

    申请人： Bo zidar Su skovi c ,  Vanja Vela ,  Mira Bun ci c

    发明人： Bo zidar Su skovi c ,  Vanja Vela ,  Mira Bun ci c

    IPC分类号： C07D307/62 ,  A61K31/34

    CPC分类号： C07D307/62

    摘要： The invention relates to the process for the preparation of new derivatives of amino-ascorbic acid, their acid and alkali salts, processes for preparation and action.According to this invention derivatives of amino-ascorbic acid are prepared by three types of reactions: 1. reductive alkylation of amino-ascorbic acid; 2. alkylation of primary and secondary amines with halogen-ascorbic acid and 3. acylation of amino-ascorbic acid.

    摘要翻译： 本发明涉及制备氨基抗坏血酸，其酸和碱盐的新衍生物，制备方法和作用的方法。 根据本发明，氨基 - 抗坏血酸的衍生物通过三种类型的反应制备：1.氨基 - 抗坏血酸的还原性烷基化; 2.用卤素 - 抗坏血酸烷基化伯胺和仲胺，和3.酰化氨基 - 抗坏血酸。

    Derivatives of amino-ascorbic acid, the processes for their preparation and use
    2.
    发明授权
    Derivatives of amino-ascorbic acid, the processes for their preparation and use 失效
    氨基抗坏血酸的衍生物，其制备和使用的过程

    公开(公告)号：US5559251A

    公开(公告)日：1996-09-24

    申请号：US190921

    申请日：1994-02-03

    申请人： Bozidar Suskovic ,  Vanja Vela ,  Mira Buncic

    发明人： Bozidar Suskovic ,  Vanja Vela ,  Mira Buncic

    IPC分类号： C07D307/62 ,  C07D305/12

    CPC分类号： C07D307/62

    摘要： The invention relates to the process for the preparation of new derivatives of amino-ascorbic acid, their acid and alkali salts, processes for preparation and action.According to this invention derivatives of amino-ascorbic acid are prepared by three types of reactions: 1. reductive alkylation of amino-ascorbic acid; 2. alkylation of primary and secondary amines with halogen-ascorbic acid and 3. acylation of amino-ascorbic acid.

    摘要翻译： 本发明涉及制备氨基抗坏血酸，其酸和碱盐的新衍生物，制备方法和作用的方法。 根据本发明，氨基 - 抗坏血酸的衍生物通过三种类型的反应制备：1.氨基 - 抗坏血酸的还原性烷基化; 2.用卤素 - 抗坏血酸烷基化伯胺和仲胺，和3.酰化氨基 - 抗坏血酸。

    Decladinosyl-macrolides with anti-inflammatory activity
    5.
    发明授权
    Decladinosyl-macrolides with anti-inflammatory activity 失效
    具有抗炎活性的宣称大肠杆菌素

    公开(公告)号：US07910559B2

    公开(公告)日：2011-03-22

    申请号：US11813876

    申请日：2006-01-13

    申请人： Ognjen Culic ,  Martina Bosnar ,  Sulejman Alihodzic ,  Gorjana Lazarevski ,  Zorica Marusic Istuk ,  Antun Hutinec ,  Vanja Vela ,  Goran Kragol

    发明人： Ognjen Culic ,  Martina Bosnar ,  Sulejman Alihodzic ,  Gorjana Lazarevski ,  Zorica Marusic Istuk ,  Antun Hutinec ,  Vanja Vela ,  Goran Kragol

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.

    摘要翻译： 本发明涉及具有抗炎活性的新型半合成大环内酯类。 更具体地说，本发明涉及在C-3位上缺少被克拉替糖糖化的14-和15-元大环内酯，其药学上可接受的衍生物，其制备方法和中间体，含有它们的药物组合物及其活性和用途 特别是与过量分泌TNF-α，IL-1，IL-6，IL-8，IL-2或IL-5相关的那些疾病的治疗中， 和/或过度淋巴细胞增殖的抑制剂; 和/或过量粒细胞脱粒。