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公开(公告)号：US20190270736A1
公开(公告)日：2019-09-05
申请号：US16412050
申请日：2019-05-14
Inventor： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC: C07D417/14 , A61K31/497 , C07D493/08 , A61K31/444 , C07D403/14 , C07D405/14 , A61K31/4192 , A61K31/4439 , C07D401/14 , A61K31/501 , C07D403/06 , A61K31/433 , C07D417/06 , A61K45/06 , A61K31/454
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20240360121A1
公开(公告)日：2024-10-31
申请号：US18597265
申请日：2024-03-06
Inventor： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
CPC classification number: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I:
Methods of inhibition GLS1 activity in a human or animal subject are also provided.-
公开(公告)号：US20230124815A1
公开(公告)日：2023-04-20
申请号：US17660541
申请日：2022-04-25
Inventor： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC: C07D417/14 , A61K31/4439 , A61K45/06 , C07D417/06 , A61K31/433 , C07D403/06 , A61K31/501 , C07D401/14 , A61K31/454 , A61K31/4192 , C07D405/14 , C07D403/14 , A61K31/444 , C07D493/08 , A61K31/497
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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公开(公告)号：US20170291895A1
公开(公告)日：2017-10-12
申请号：US15624168
申请日：2017-06-15
Inventor： Maria Emilia DI FRANCESCO , Philip JONES , Timothy HEFFERNAN , Matthew M. HAMILTON , Zhijun KANG , Michael J. SOTH , Jason P. BURKE , Kang LE , Christopher Lawrence CARROLL , Wylie S. PALMER , Richard LEWIS , Timothy MCAFOOS , Barbara CZAKO , Gang LIU , Jay THEROFF , Zachary HERRERA , Anne YAU
IPC: C07D417/14 , C07D403/06 , C07D405/14 , A61K31/4192 , C07D493/08 , A61K31/4439 , C07D417/06 , C07D403/14 , A61K31/444 , A61K31/501 , C07D401/14 , A61K31/433 , A61K31/497 , A61K31/454 , A61K45/06
CPC classification number: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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