公开(公告)号：US20110267622A1

公开(公告)日：2011-11-03

申请号：US13181547

申请日：2011-07-13

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US07999942B2

公开(公告)日：2011-08-16

申请号：US12535707

申请日：2009-08-05

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US20120113428A1

公开(公告)日：2012-05-10

申请号：US13348663

申请日：2012-01-12

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US08111400B2

公开(公告)日：2012-02-07

申请号：US13181547

申请日：2011-07-13

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/00

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US20080198384A1

公开(公告)日：2008-08-21

申请号：US12149158

申请日：2008-04-28

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

公开(公告)号：US20090296095A1

公开(公告)日：2009-12-03

申请号：US12535707

申请日：2009-08-05

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55 ,  G01N21/01

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US07443507B2

公开(公告)日：2008-10-28

申请号：US10540940

申请日：2002-12-25

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括：薄导电层，包括形成在透明基板的表面上的至少一个导电元件; 照明系统，其可控制以照亮所述导电层和所述衬底之间的界面; 感光表面，其产生响应于来自所述界面的区域反射的来自所述光源的光的信号; 形成有至少一个流动通道的流动池，所述流动通道具有由壁限定的内腔，壁的至少一部分由弹性材料形成，并且其一部分由导电层的区域形成; 以及至少一个中空针，其具有与所述针的内腔连通的出口孔，并且通过用所述至少一个针刺穿所述弹性材料，使得所述流动通道与所述针的内腔之间能够流动，使得所述出口与所述流动通道连通 流明。

公开(公告)号：US08363223B2

公开(公告)日：2013-01-29

申请号：US13348663

申请日：2012-01-12

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US07586616B2

公开(公告)日：2009-09-08

申请号：US12149158

申请日：2008-04-28

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括：薄导电层，包括形成在透明基板的表面上的至少一个导电元件; 照明系统，其可控制以照亮所述导电层和所述衬底之间的界面; 感光表面，其产生响应于来自所述界面的区域反射的来自所述光源的光的信号; 形成有至少一个流动通道的流动池，所述流动通道具有由壁限定的内腔，壁的至少一部分由弹性材料形成，并且其一部分由导电层的区域形成; 以及至少一个中空针，其具有与所述针的内腔连通的出口孔，并且通过用所述至少一个针刺穿所述弹性材料，使得所述流动通道与所述针的内腔之间能够流动，使得所述出口与所述流动通道连通 流明。

公开(公告)号：US20100220330A1

公开(公告)日：2010-09-02

申请号：US12451547

申请日：2008-05-21

申请人： Boaz Ran ,  Tal Rosenzweig ,  Ariel G. Notcovich ,  Ariel Shemesh ,  Yochanan Uri ,  Michael Kanevsky ,  James W. Hillendahl ,  Barak Abraham Liraz

发明人： Boaz Ran ,  Tal Rosenzweig ,  Ariel G. Notcovich ,  Ariel Shemesh ,  Yochanan Uri ,  Michael Kanevsky ,  James W. Hillendahl ,  Barak Abraham Liraz

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.

摘要翻译： 基于SPR或其他基于光学共振的分析系统，其中以样品的多个角度提供光，然后处理由样本改变的光以仅选择一些光。 可选地，该处理以特定入射角选择光。 可选地，通过在2D成像器阵列上对光进行成像来进行检测。