公开(公告)号：US08530243B2

公开(公告)日：2013-09-10

申请号：US12762338

申请日：2010-04-18

申请人： Boaz Ran ,  Itay Barak

发明人： Boaz Ran ,  Itay Barak

IPC分类号： G01N21/00 ,  G01N21/55

CPC分类号： G01N21/553 ,  G02B3/005 ,  G02B5/008

摘要： A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.

摘要翻译： 一种用于在全内反射下测量ev逝波现象的系统，所述系统包括：a）感测表面，包括多个感兴趣的区域; b）照明子系统，包括光源，其在入射角范围上照射感测表面上的每个感兴趣区域; c）检测器，其响应于其在不同位置处接收的光的强度不同; 以及d）包括主要光学元件和多个次要元件的投影光学元件，所述主要光学器件将所述照射的感测表面的图像投影到所述次级元件上，所述次级元件将其接收的光投射到所述检测器上，使得可以确定， 根据检测器的响应，从感兴趣区域反射多少光，作为该区域的角度范围内的入射角的函数。

公开(公告)号：US07999942B2

公开(公告)日：2011-08-16

申请号：US12535707

申请日：2009-08-05

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US20100220330A1

公开(公告)日：2010-09-02

申请号：US12451547

申请日：2008-05-21

申请人： Boaz Ran ,  Tal Rosenzweig ,  Ariel G. Notcovich ,  Ariel Shemesh ,  Yochanan Uri ,  Michael Kanevsky ,  James W. Hillendahl ,  Barak Abraham Liraz

发明人： Boaz Ran ,  Tal Rosenzweig ,  Ariel G. Notcovich ,  Ariel Shemesh ,  Yochanan Uri ,  Michael Kanevsky ,  James W. Hillendahl ,  Barak Abraham Liraz

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.

摘要翻译： 基于SPR或其他基于光学共振的分析系统，其中以样品的多个角度提供光，然后处理由样本改变的光以仅选择一些光。 可选地，该处理以特定入射角选择光。 可选地，通过在2D成像器阵列上对光进行成像来进行检测。

公开(公告)号：US20090296095A1

公开(公告)日：2009-12-03

申请号：US12535707

申请日：2009-08-05

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55 ,  G01N21/01

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US07443507B2

公开(公告)日：2008-10-28

申请号：US10540940

申请日：2002-12-25

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括：薄导电层，包括形成在透明基板的表面上的至少一个导电元件; 照明系统，其可控制以照亮所述导电层和所述衬底之间的界面; 感光表面，其产生响应于来自所述界面的区域反射的来自所述光源的光的信号; 形成有至少一个流动通道的流动池，所述流动通道具有由壁限定的内腔，壁的至少一部分由弹性材料形成，并且其一部分由导电层的区域形成; 以及至少一个中空针，其具有与所述针的内腔连通的出口孔，并且通过用所述至少一个针刺穿所述弹性材料，使得所述流动通道与所述针的内腔之间能够流动，使得所述出口与所述流动通道连通 流明。

公开(公告)号：US20110267622A1

公开(公告)日：2011-11-03

申请号：US13181547

申请日：2011-07-13

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US20120113428A1

公开(公告)日：2012-05-10

申请号：US13348663

申请日：2012-01-12

申请人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz RAN ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US08111400B2

公开(公告)日：2012-02-07

申请号：US13181547

申请日：2011-07-13

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/00

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate, a light source that illuminates an interface between the conducting layer and the substrate, a photosensitive surface that generates signals from light reflected from the interface, a flow cell formed with at least one flow channel having a lumen defined by a wall formed from an elastic material and from a region of the conducting layer, and at least one hollow fluid-providing flow control apparatus having a lumen and an orifice communicating with its lumen. Fluid flow is enabled between the flow channel and the lumen of the flow control apparatus by forcing an end of the flow control apparatus through the elastic material so that the orifice communicates with the flow channel lumen.

摘要翻译： 一种SPR传感器，包括薄导电层，该导电层包括形成在透明基板的表面上的至少一个导电元件，照亮导电层和基板之间的界面的光源，从该界面反射的光产生信号的光敏表面 ，形成有至少一个流动通道的流动池，所述流动通道具有由由弹性材料形成的壁和从导电层的区域限定的内腔，以及至少一个中空流体供应流量控制装置，其具有内腔和孔口连通 与其流明。 通过迫使流量控制装置的一端通过弹性材料使得流体通道与流动控制装置的内腔之间能够进行流体流动，使得孔口与流动通道内腔连通。

公开(公告)号：US20110136250A1

公开(公告)日：2011-06-09

申请号：US12954955

申请日：2010-11-29

申请人： Boaz RAN ,  Chanan Sluszny ,  Shay Nimri

发明人： Boaz RAN ,  Chanan Sluszny ,  Shay Nimri

IPC分类号： G01N21/00 ,  G01J1/58 ,  G01N21/75 ,  G01N1/00

CPC分类号： G01N21/76 ,  G01N15/0612 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/78 ,  G01N35/0098 ,  G01N2015/1486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2035/1046 ,  Y10T436/25

摘要： A method of determining a normalized quantity of an analyte adhering to beads in a detection area of a bead-based assaying system, the method comprising: a) causing a complex of the analyte to fluorescently or chemically emit a first light, or to release a dye; b) measuring an integrated intensity of the first light emitted from the beads in the detection area, or a concentration of the dye released from the beads in the detection area, or both; c) causing light to interact with the beads in the detection area, the interaction not depending on whether or how much analyte is adhering to the beads; d) measuring a second light resulting from the interaction with the beads which does not depend on the analyte; and e) determining the normalized quantity of analyte from the integrated intensity of the first light or concentration of the dye or both, and from the measured second light.

摘要翻译： 一种确定在珠基测定系统的检测区域中附着于珠的分析物的归一化量的方法，所述方法包括：a）使分析物的复合物荧光或化学发射第一光，或释放 染料; b）测量从检测区域中的珠子发射的第一光的集成强度或从检测区域中的珠粒释放的染料的浓度，或两者; c）使光与检测区域中的珠粒相互作用，相互作用不取决于是否或多少分析物粘附到珠粒上; d）测量与不依赖于分析物的珠的相互作用产生的第二光; 以及e）根据所述第一光的积分强度或所述染料或两者的浓度以及所测量的第二光确定归一化的分析物量。

公开(公告)号：US20080198384A1

公开(公告)日：2008-08-21

申请号：US12149158

申请日：2008-04-28

申请人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

发明人： Boaz Ran ,  Ariel G. Notcovich ,  Ariel Lipson ,  Shay Nimri ,  Stephen G. Lipson ,  Doron Lipson

IPC分类号： G01N21/55

CPC分类号： G01N21/55 ,  G01N21/553 ,  G01N2021/058

摘要： An SPR sensor comprising: a thin conducting layer comprising at least one conductive element formed on a surface of a transparent substrate; an illumination system controllable to illuminate an interface between the conducting layer and the substrate; a photosensitive surface that generates signals responsive to light from the light source that is reflected from a region of the interface; a flow cell formed with at least one flow channel having a lumen defined by a wall at least a portion of which is formed from an elastic material and a portion of which is formed by a region of the conducting layer; and at least one hollow needle having an exit orifice communicating with the needle's lumen and wherein fluid flow is enabled between the flow channel and the needle's lumen by puncturing the elastic material with the at least one needle so that the exit orifice communicates with the flow channel lumen.