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1.发明授权Method for recognition and reduction of blood speckle in blood vessel imaging system 失效血管成像系统中血斑识别和减少的方法
公开(公告)号：US5520185A
公开(公告)日：1996-05-28
申请号：US340178
申请日：1994-11-15
申请人： Bobby Soni , Richard Didday , Kean Hurley
发明人： Bobby Soni , Richard Didday , Kean Hurley
CPC分类号： A61B8/06 , A61B8/12 , G01S7/52036 , Y10S128/916
摘要： In an ultrasound imaging system, ultrasound echoes representing vessel walls are distinguished from ultrasound echoes from blood by using a classifier which employs the mean and variance of the raw data of gray intensities as acquired directly from an ultrasound scanner detector. In a specific embodiment, the statistical parameters of mean and variance are determined in the course of real-time processing and prior to attempted classification and then are used as parameters representing the true image as acquired.
摘要翻译： 在超声成像系统中，通过使用分类器来区分代表血管壁的超声回波，其使用从超声波扫描仪检测器直接获取的灰度强度的原始数据的平均值和方差。 在具体实施例中，在实时处理和尝试分类之前确定平均值和方差的统计参数，然后用作表示所获取的真实图像的参数。
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2.发明授权Method for recognition and reduction of blood speckle in blood vessel imaging system 失效血管成像系统中血斑识别和减少的方法
公开(公告)号：US5363850A
公开(公告)日：1994-11-15
申请号：US187584
申请日：1994-01-26
申请人： Bobby Soni , Richard Didday , Kean Hurley
发明人： Bobby Soni , Richard Didday , Kean Hurley
CPC分类号： A61B8/06 , A61B8/12 , G01S7/52036 , Y10S128/916
摘要： In an ultrasound imaging system, ultrasound echoes representing vessel walls are distinguished from ultrasound echoes from blood by using a classifier which employs the mean and variance of the raw data of gray intensities as acquired directly from an ultrasound scanner detector. In a specific embodiment, the statistical parameters of mean and variance are determined in the course of real-time processing and prior to attempted classification and then are used as parameters representing the true image as acquired.
摘要翻译： 在超声成像系统中，通过使用分类器来区分代表血管壁的超声回波，其使用从超声波扫描仪检测器直接获取的灰度强度的原始数据的平均值和方差。 在具体实施例中，在实时处理和尝试分类之前确定平均值和方差的统计参数，然后用作表示所获取的真实图像的参数。
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公开(公告)号：US20070009478A1
公开(公告)日：2007-01-11
申请号：US11420546
申请日：2006-05-26
申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
发明人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
IPC分类号： A61K38/19 , C07K14/535
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
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公开(公告)号：US07655766B2
公开(公告)日：2010-02-02
申请号：US11742445
申请日：2007-04-30
申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
发明人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。
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5.发明申请Method for the treatment of neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (G-CSF) variant 审中-公开通过施用多聚乙二醇化粒细胞集落刺激因子（G-CSF）变体治疗嗜中性白细胞减少的方法公开(公告)号：US20090203601A1
公开(公告)日：2009-08-13
申请号：US12313902
申请日：2008-11-25
CPC分类号： A61K38/193 , A61K47/60 , A61K2300/00
摘要： The invention relates to a method for treating or preventing neutropenia in a patient receiving chemotherapy by administering a multi-PEGylated granulocyte colony stimulating factor (G-CSF) variant on the same day that chemotherapy is administered.
摘要翻译： 本发明涉及通过在施用化疗的同一天施用多聚乙二醇化粒细胞集落刺激因子（G-CSF）变体来治疗或预防接受化疗的患者的中性粒细胞减少的方法。
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6.发明授权Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF 失效包含聚乙二醇化G-CSF的位置PEG异构体的混合物的组合物公开(公告)号：US07381805B2
公开(公告)日：2008-06-03
申请号：US11420546
申请日：2006-05-26
申请人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
发明人： Carsten Germansen , Bobby Soni , Grethe Rasmussen
CPC分类号： C07K14/535 , A61K38/193 , A61K47/60 , C12P21/02
摘要： A method for increasing the stability and uniformity of a PEGylated G-CSF polypeptide having at least one PEG moiety attached to the epsilon amino group of a lysine residue or the N-terminal amino group and at least one PEG moiety attached to a hydroxyl group, comprising subjecting the polypeptide to an elevated pH of above 8.0 for a period of time suitable to remove PEG moieties attached to a hydroxyl group, and reducing the pH to about 8.0 or lower; as well as PEGylated G-CSF polypeptides and compositions produced according to the method and methods for increasing neutrophil levels in a patient using the PEGylated G-CSF polypeptides and compositions.
摘要翻译： 增加具有连接到赖氨酸残基或N-末端氨基的ε氨基上的至少一个PEG部分和与羟基连接的至少一个PEG部分的聚乙二醇化G-CSF多肽的稳定性和均匀性的方法， 包括使多肽经历高于8.0的升高的pH适合于除去连接到羟基上的PEG部分并将pH降低至约8.0或更低的时间; 以及聚乙二醇化G-CSF多肽和根据使用聚乙二醇化G-CSF多肽和组合物在患者中增加嗜中性粒细胞水平的方法和方法产生的组合物。
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