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    PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
    1.
    发明申请
    PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF 有权

    公开(公告)号：US20210221852A1

    公开(公告)日：2021-07-22

    申请号：US17215636

    申请日：2021-03-29

    申请人： Boehringer Ingelheim Animal Health USA Inc.

    发明人： Luis Alejandro HERNANDEZ ,  Christine Margaret MUEHLENTHALER ,  Eric Martin VAUGHN ,  Gregory HAIWICK

    IPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  C12P21/02

    摘要： Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2 protein are used in a method for the treatment or prevention of an infection with PCV2 of the same PCV2b and/or different subtype; the reduction, prevention or treatment of clinical signs caused by an infection with PCV2 of the same PCV2b or a different subtype; and/or the prevention or treatment of a disease caused by an infection with PCV2 of the same PCV2b and/or a different subtype. The present invention in particular relates to PCV2 subtype b (PCV2b) ORF2 proteins characterized in that they contain at least one mutation in the BC loop that such that the expressed protein is preferably expressed in a higher amount compared to a PCV2 ORF2 protein that does not contain such mutation.

    PCV2 ORF2 CARRIER PLATFORM
    4.
    发明申请
    PCV2 ORF2 CARRIER PLATFORM 审中-公开

    公开(公告)号：US20200237894A1

    公开(公告)日：2020-07-30

    申请号：US16749241

    申请日：2020-01-22

    申请人： Boehringer Ingelheim Animal Health USA Inc.

    发明人： Luis Alejandro HERNANDEZ ,  Eric Martin VAUGHN

    IPC分类号： A61K39/12 ,  C07K14/005 ,  A61P31/20 ,  C07K1/14 ,  C12N15/62 ,  G01N33/53 ,  G01N33/566

    摘要： The present invention relates to an immunogen-carrier, wherein the immunogen-carrier is preferably a virus-like particle (VLP) composed of a plurality of a modified PCV2 ORF2 protein. In particular, the present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a compliance marker for vaccines including a subunit antigen, and a DIVA (Differentiating Infected from Vaccinated Animals) system which makes it possible to differentiate between animals infected with a pathogen and animals treated with a subunit antigen derived from said pathogen.