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公开(公告)号：US5948643A
公开(公告)日：1999-09-07
申请号：US968751
申请日：1997-08-13
CPC分类号： C07K14/4702
摘要： Compositions of matter consisting of a family of related nucleotide sequences that encode proteins, termed BRCA1 Modulator Proteins, that bind to the tumor suppressor gene product BRCA1, and methods of using the nucleotide sequences and the proteins encoded thereby, to diagnose and/or treat disease where the BRCA1 Modulator Proteins have an apparent molecular weight of 45-97 kdaltons and are characterized by having at least one leucine zipper domain, and optionally a zinc finger domain.
摘要翻译： 由编码蛋白质的相关核苷酸序列家族组成的物质组成，称为BRCA1调节蛋白，其结合肿瘤抑制基因产物BRCA1，以及使用其编码的核苷酸序列和蛋白质的方法诊断和/或治疗疾病 其中BRCA1调节蛋白的表观分子量为45-97千道尔顿，其特征在于具有至少一个亮氨酸拉链结构域和任选的锌指结构域。
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公开(公告)号：US5763573A
公开(公告)日：1998-06-09
申请号：US380206
申请日：1995-01-30
CPC分类号： C07K14/4703 , C07K16/18 , A61K38/00
摘要： Peptides, that inhibit GAP stimulated ras p21 hydrolysis of GTP; peptides that mediate dissociation of GDP from ras p21-GTP complex; and antibodies to the peptides are described. These peptides are useful as cancer diagnostics and therapeutics, particularly to detect cancer cells with an over expression of normal or oncogenic ras p21 protein and to treat cancer caused by ras oncogene. Methods for assaying products of oncogenes using the described peptides and antibodies are also disclosed. Method for treating cancer caused by ras oncogenes is also disclosed.
摘要翻译： 肽，抑制GAP刺激ras p21水解GTP; 介导国内生产总值与ras p21-GTP复合物解离的肽; 并描述了对肽的抗体。 这些肽可用作癌症诊断和治疗，特别是用正常或致癌性ras p21蛋白过表达检测癌细胞，并用于治疗由ras致癌基因引起的癌症。 还公开了使用所述肽和抗体测定癌基因产物的方法。 还公开了用于治疗由ras致癌物引起的癌症的方法。
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