公开(公告)号：US20100298930A1

公开(公告)日：2010-11-25

申请号：US12745700

申请日：2008-12-02

申请人： Boris Orlov

发明人： Boris Orlov

IPC分类号： A61F2/24

CPC分类号： A61F2/2466 ,  A61B17/3421 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00783 ,  A61B2017/22069 ,  A61B2017/22098 ,  A61B2017/308 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2463

摘要： Disclosed are a method for engaging cardiac valve leaflets, including a) directing a distal end of an elongated catheter body of a leaflet-engaging device into a coronary sinus of a heart, b) passing a first leaflet-engaging component located proximate to the distal end of the elongated catheter body of the leaflet-engaging device through cardiac tissue separating the coronary sinus and a left atrium of the heart to enter a left atrium of the heart, and c) engaging a first cardiac valve leaflet with the first leaflet-engaging component, thereby engaging at least one cardiac valve leaflet. Related apparatus and methods are also described.

摘要翻译： 公开了一种用于接合心脏瓣膜小叶的方法，包括a）将小叶接合装置的细长导管体的远端引导到心脏的冠状窦中，b）使位于远端的第一小叶接合组件 通过分离冠状窦和心脏的左心房的心脏组织进入小叶接合装置的细长导管体的端部，以进入心脏的左心房，以及c）使第一心脏瓣膜小叶与第一传单接合 从而接合至少一个心脏瓣膜小叶。 还描述了相关装置和方法。

公开(公告)号：US20090198324A1

公开(公告)日：2009-08-06

申请号：US12302901

申请日：2007-05-21

申请人： Boris Orlov

发明人： Boris Orlov

IPC分类号： A61F2/24

CPC分类号： A61B17/115 ,  A61F2/06 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2463 ,  A61F2250/0018 ,  A61F2250/0029

摘要： Disclosed are methods for treatment of cardiac valve including augmenting a cardiac leaflet with the help of a ring associated with a membrane. Also disclosed are methods for treatment of cardiac valves including augmenting the tissue surrounding a cardiac valve, for example with the help of a tubular or annular implant, allowing relocation of the valve. In embodiments, the methods of the present invention improve leaflet coaptation, which in embodiments is useful for treating conditions such as ischemic mitral regurgitation. Also disclosed are devices useful for implementing the methods of the present invention.

摘要翻译： 公开了用于治疗心脏瓣膜的方法，包括借助与膜相关联的环来增强心脏小叶。 还公开了用于治疗心脏瓣膜的方法，包括例如借助于管状或环形植入物增加心脏瓣膜周围的组织，允许瓣膜的重新定位。 在实施方案中，本发明的方法改善叶片接合，其在实施方案中可用于治疗诸如缺血性二尖瓣反流的病症。 还公开了可用于实现本发明的方法的装置。

公开(公告)号：US20090188964A1

公开(公告)日：2009-07-30

申请号：US12302900

申请日：2007-05-21

申请人： Boris Orlov

发明人： Boris Orlov

IPC分类号： A61B17/10

CPC分类号： A61F2/2445 ,  A61B17/115 ,  A61F2/2463 ,  A61F2/2466 ,  A61F2250/0018 ,  A61F2250/0029

摘要： Disclosed are methods for augmenting tissue, for example membranes such as cardiac leaflets and tissue surrounding a cardiac valve, which in embodiments improve leaflet coaptation. Also disclosed are devices useful for augmenting tissue.

摘要翻译： 公开了用于增加组织的方法，例如膜，例如心脏小叶和围绕心脏瓣膜的组织，其在实施例中改进了叶片接合。 还公开了可用于增加组织的装置。

公开(公告)号：US08758431B2

公开(公告)日：2014-06-24

申请号：US12602807

申请日：2008-06-04

申请人： Boris Orlov ,  Nisan Zef

发明人： Boris Orlov ,  Nisan Zef

IPC分类号： A61F2/24

CPC分类号： A61F2/2466 ,  A61B17/0057 ,  A61B17/32 ,  A61B2017/00252 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/306 ,  A61B2017/320048 ,  A61B2090/036 ,  A61F2/2463

摘要： Methods and devices for augmenting an atrioventricular valve leaflet is disclosed. A method according to an exemplary embodiment includes piercing a leaflet of the valve to at least a portion of the leaflet's thickness to form a pierced section; and extending the leaflet using said pierced section. A device according to an exemplary embodiment of the invention includes a catheter comprising: a longitudinal tube having a lumen; and a cutting element extendable from the lumen. The cutting element is adapted for forming a limited cut in an atrioventricular valve. A device according to another exemplary embodiment of the invention includes a catheter comprising a longitudinal tube having a lumen; a cutting element extendable from the lumen and adapted for forming a cut in a leaflet of an atrioventricular valve; and a frame, configured to attach to the leaflet and stay attached to the leaflet when the heart beats.

摘要翻译： 公开了用于增加房室瓣膜小叶的方法和装置。 根据示例性实施例的方法包括将瓣膜的小叶刺穿到小叶厚度的至少一部分以形成刺穿部分; 并使用所述刺穿部分延伸传单。 根据本发明的示例性实施例的装置包括导管，其包括：具有内腔的纵向管; 以及可从内腔延伸的切割元件。 切割元件适于在房室瓣中形成有限的切口。 根据本发明的另一示例性实施例的装置包括导管，其包括具有内腔的纵向管; 切割元件，其可从内腔延伸并适于在房室瓣的小叶中形成切口; 以及框架，被配置为附接到所述传单并且当心跳时保持附着于所述传单。

公开(公告)号：US20100204662A1

公开(公告)日：2010-08-12

申请号：US12602807

申请日：2008-06-04

申请人： Boris Orlov ,  Nisan Zef

发明人： Boris Orlov ,  Nisan Zef

IPC分类号： A61M25/00 ,  A61F2/24 ,  A61B17/32

CPC分类号： A61F2/2466 ,  A61B17/0057 ,  A61B17/32 ,  A61B2017/00252 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/306 ,  A61B2017/320048 ,  A61B2090/036 ,  A61F2/2463

摘要： Methods and devices for augmenting an atrioventricular valve leaflet is disclosed. A method according to an exemplary embodiment includes piercing a leaflet of the valve to at least a portion of the leaflet's thickness to form a pierced section; and extending the leaflet using said pierced section. A device according to an exemplary embodiment of the invention includes a catheter comprising: a longitudinal tube having a lumen; and a cutting element extendable from the lumen. The cutting element is adapted for forming a limited cut in an atrioventricular valve. A device according to another exemplary embodiment of the invention includes a catheter comprising a longitudinal tube having a lumen; a cutting element extendable from the lumen and adapted for forming a cut in a leaflet of an atrioventricular valve; and a frame, configured to attach to the leaflet and stay attached to the leaflet when the heart beats.

摘要翻译： 公开了用于增加房室瓣膜小叶的方法和装置。 根据示例性实施例的方法包括将瓣膜的小叶刺穿到小叶厚度的至少一部分以形成刺穿部分; 并使用所述刺穿部分延伸传单。 根据本发明的示例性实施例的装置包括导管，其包括：具有内腔的纵向管; 以及可从内腔延伸的切割元件。 切割元件适于在房室瓣中形成有限的切口。 根据本发明的另一示例性实施例的装置包括导管，其包括具有内腔的纵向管; 切割元件，其可从内腔延伸并适于在房室瓣的小叶中形成切口; 以及框架，被配置为附接到所述传单并且当心跳时保持附着于所述传单。

公开(公告)号：US20120179184A1

公开(公告)日：2012-07-12

申请号：US13496226

申请日：2010-09-15

申请人： Boris Orlov

发明人： Boris Orlov

IPC分类号： A61B17/32

CPC分类号： A61F2/2463 ,  A61B17/0643 ,  A61B90/02 ,  A61B2017/00004 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/00867 ,  A61B2017/0641

摘要： A device for remodeling atrioventricular valve leaflets including one or more stretching members and one or more leaflet engaging elements, wherein each stretching member includes at least one leaflet engaging element, the leaflet engaging elements are configured to penetrate a valve leaflet, and the stretching members are configured to be positioned externally to a plane of the leaflet when the leaflet engaging elements have penetrated a valve leaflet. A method for remodeling atrioventricular valve leaflets including inserting one or more leaflet engaging elements into an atrioventricular valve leaflet, and using stretching members positioned externally to a plane of the leaflet to apply a stretching force on the atrioventricular valve leaflet. Related apparatus and methods are also described.

摘要翻译： 一种用于重建房室瓣膜小叶的装置，包括一个或多个拉伸构件和一个或多个叶片接合元件，其中每个拉伸构件包括至少一个叶片接合元件，所述小叶接合元件构造成穿透瓣叶，并且拉伸构件 构造成当所述传单接合元件已经穿过瓣叶时被定位在所述叶片的平面的外部。 一种用于重建房室瓣膜小叶的方法，包括将一个或多个小叶接合元件插入到房室瓣膜小叶中，并且使用定位在小叶平面外部的拉伸构件，以在房室瓣膜小叶上施加拉伸力。 还描述了相关装置和方法。