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公开(公告)号：US20240058610A1
公开(公告)日：2024-02-22
申请号：US18230941
申请日：2023-08-07
IPC分类号： A61N1/36
CPC分类号： A61N1/36139
摘要： Systems and methods for closed-loop control of electrostimulation based on signal features derived from evoked neural activities are disclosed. A system comprises an electrostimulator to deliver a stimulation therapy, a sensing circuit to sense an evoked response induced by the stimulation therapy, and a controller circuit to identify, from a plurality of candidate signal features, a target signal feature that satisfies a performance criterion for distinguishing a first stimulation effect according to a first stimulation setting from a second stimulation effect according to a different second stimulation setting. The target signal feature can be identified based on evaluations of a discrimination metric for each of the candidate signal features. The controller circuit can determine a value of the target signal feature from the sensed evoked response, and control the electrostimulator to adjust the stimulation therapy based on the value of the target signal feature.
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公开(公告)号：US11813458B2
公开(公告)日：2023-11-14
申请号：US17653814
申请日：2022-03-07
CPC分类号： A61N1/3614 , A61N1/0534
摘要： Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.
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公开(公告)号：US20230045684A1
公开(公告)日：2023-02-09
申请号：US17975468
申请日：2022-10-27
摘要： An example of a system for delivering neurostimulation may include a programming control circuit and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a stimulation configuration. The stimulation control circuit may be configured to specify the stimulation configuration, and may include volume definition circuitry and stimulation configuration circuitry. The volume definition circuitry may be configured to determine one or more test volumes, determine a clinical effect resulting from the one or more test volumes each being activated by the neurostimulation, and determine a target volume using the determined clinical effect. The stimulation configuration circuitry may be configured to generate the specified stimulation configuration for activating the target volume.
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公开(公告)号：US20220355112A1
公开(公告)日：2022-11-10
申请号：US17730976
申请日：2022-04-27
摘要： A system may include a stimulator, sensing circuitry and a controller. The stimulator may be operably connected to at least one stimulation electrode, and configured to deliver an electrical waveform for an electrical therapy using the at least one stimulation electrode. The sensing circuitry may be operably connected to at least one sensing electrode, and configured to sense electrical potentials that are evoked by the electrical waveform to provide sensed evoked signals. The controller may be operably connected to the stimulator and the sensing circuitry. The controller may be configured to automatically define a sampling window, sample the sensed evoked potentials during the sampling window to provide sampled values, detect at least one feature from the sampled values, and automatically provide feedback for closed-loop control of the electrical therapy based on the at least one feature.
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公开(公告)号：US20220323777A1
公开(公告)日：2022-10-13
申请号：US17689448
申请日：2022-03-08
发明人： Tianhe Zhang , Changfang Zhu , Rosana Esteller
摘要： An example of a neurostimulation system may include a programming control circuit, a sensing circuit, and a stimulation control circuit. The programming control circuit may be configured to generate stimulation parameters controlling delivery of neurostimulation according to stimulation waveform(s) and stimulation field(s). The sensing circuit may be configured to sense signals. The stimulation control circuit may be configured to determine the stimulation waveform(s) and the stimulation field(s) based on a lead configuration and may be configured to determine first and second electrodes of respective first and second leads, receive first and second signals sensed using the first and second electrodes, detect corresponding signal features from the first and second signals, determine a feature delay between the detected signal features, and determine a need for adjusting the lead configuration using the feature delay. The signal features are associated with a response of the patient to the neurostimulation.
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公开(公告)号：US11195609B2
公开(公告)日：2021-12-07
申请号：US16219551
申请日：2018-12-13
IPC分类号： A61N1/36 , G16H20/40 , G16H40/00 , G16H40/60 , G16H40/67 , G16H50/50 , G16H30/40 , A61N1/375
摘要： This document discusses, among other things, systems and methods for delivering electrostimulation to specific tissue of a patient. An example of a system can receive a three-dimensional voxelized model representing a plurality of regions each specified as a target region or an avoidance region. The system includes control circuitry to determine a metric value using the voxelized model. The metric value indicates a clinical effect of electrostimulation on the plurality of regions according to a stimulation current and a current fractionalization. The control circuitry can determine a desired stimulation current that results in a first metric value satisfying a clinical effect condition. The system can generate a stimulation configuration including the desired stimulation current and the current fractionalization corresponding to the first metric value, and deliver tissue stimulation according to the stimulation configuration.
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公开(公告)号：US20210046322A1
公开(公告)日：2021-02-18
申请号：US16990691
申请日：2020-08-11
发明人： Tianhe Zhang , Rosana Esteller
摘要： An example of a neurostimulation system may include a storage device for storing data representing physiological signals and a user interface including a user input, a display screen, and a presentation control circuit. The user input may be configured to receive a selection of signal(s) from the physiological signals and a selection of viewing mode from viewing modes including a metric mode and/or a presence mode. The metric mode allows for visualization of a signal property indicated by a parameter measured from the selected signal(s). The presence mode allows for viewing presence of a feature in the selected signal(s). The presentation control circuit may be configured to allow for the selection of the signal(s) and the viewing mode, to determine a segment of each of the selected signal(s) for presentation according to the selected viewing mode, and to present the determined segment on the display screen.
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公开(公告)号：US20200376272A1
公开(公告)日：2020-12-03
申请号：US16879018
申请日：2020-05-20
发明人： Jessica Block , Tianhe Zhang , Natalie A. Brill
IPC分类号： A61N1/36
摘要： Systems and methods for optimizing neuromodulation field design for pain therapy are discussed. An exemplary neuromodulation system includes an electrostimulator to stimulate target tissue to induce paresthesia, a data receiver to receive pain data including pain sites experiencing pain, and to receive patient feedback on the induced paresthesia including paresthesia sites experiencing paresthesia. The neuromodulation system includes a processor circuit configured to generate a spatial correspondence indication between the pain sites and the paresthesia sites over one or more dermatomes, determine an anodic weight and a cathodic weight for each of multiple electrode locations using the spatial correspondence indication, and generate a stimulation field definition for neuromodulation pain therapy.
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公开(公告)号：US20190209849A1
公开(公告)日：2019-07-11
申请号：US16242461
申请日：2019-01-08
CPC分类号： A61N1/37247 , A61N1/36062 , A61N1/36185
摘要： A system for planning or conducting stimulation includes a display; and a processor that executes instructions configured for: displaying, on the display, a representation of a stimulation effect; obtaining and displaying, on the display, a path for migration of the stimulation effect; receiving a duration or rate for migration of the stimulation effect; and determining a selection of one of more electrodes or optical stimulators for one or more stimulation leads of a stimulation system to produce the stimulation effect and conduct the migration of the stimulation effect along the path according to the duration or rate.
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10.发明申请公开(公告)号：US20180369607A1
公开(公告)日：2018-12-27
申请号：US16017601
申请日：2018-06-25
发明人： Tianhe Zhang , Rosana Esteller
IPC分类号： A61N5/06 , A61B5/04 , A61B5/0484
摘要： An optical stimulation system includes a lead, a control module, and a control interface. The lead includes light emitters for emitting light having wavelengths that activate light-sensitive neurons. The light-sensitive neurons generate either an excitatory response or an inhibitory response when activated depending on the wavelength of the emitted light. The control module directs the emission of light from the light emitters using a set of stimulation parameters. The control interface includes user-selectable controls to adjust the stimulation parameters. The user-selectable controls include a graphical representation of a light emitter for each light emitter. Each graphical representation includes one or more user-selectable emitter controls to indicate whether a corresponding light emitter emits light and, if so, whether the emitted light generates an excitatory response or an inhibitory response from activated light-sensitive neurons.
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