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1.发明公开公开(公告)号：US20240342480A1
公开(公告)日：2024-10-17
申请号：US18753787
申请日：2024-06-25
发明人： Que T. Doan , Michael A. Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36121 , A61N1/36062 , A61N1/36135 , A61N1/36175 , A61N1/36192 , A61N1/36196
摘要： A method and external device for providing sub-perception stimulation to a patient via an implantable stimulator device is disclosed. Stimulation parameters for the patient are determined that provide sub-perception stimulation to address a symptom of the patient. A schedule is determined to provide scheduled boluses of stimulation, where each bolus comprises a duration during which stimulation is applied to the patient in accordance with the stimulation parameters, and where the scheduled boluses are separated by off times when no stimulation is provided to the patient. Preferably, the duration of each of the scheduled boluses is 3 minutes or longer, and the duration of each of the off times is 30 minutes or greater. Additional boluses can be provided on demand in addition to the scheduled boluses by selecting an option on the external device, although the provision of such additional boluses may be constrained by a lockout period.
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公开(公告)号：US20240293667A1
公开(公告)日：2024-09-05
申请号：US18656175
申请日：2024-05-06
CPC分类号： A61N1/0551 , A61N1/3604 , A61N1/36062 , A61N1/36071 , A61N1/36125 , A61N1/36178 , A61N1/37217 , A61N1/36153 , A61N1/36157
摘要： An implantable pulse generator (IPG) is disclosed having a plurality of electrode nodes, each electrode node configured to be coupled to an electrode to provide stimulation pulses to a patient's tissue. The IPG includes a digital-to-analog converter configured to amplify a reference current to a first current specified by first control signals; a first resistance configured to receive the first current, wherein a voltage across the first resistance is held to a reference voltage at a first node; a plurality of branches each comprising a second resistance and configured to produce a branch current, wherein a voltage across each second resistance is held to the reference voltage at second nodes; and a switch matrix configurable to selectively couple any branch current to any of the electrode nodes via the second nodes.
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公开(公告)号：US12070597B2
公开(公告)日：2024-08-27
申请号：US16766978
申请日：2018-11-26
发明人： Yael Hanein , Niyazi Serdar Sariciftci , Eric Daniel Glowacki , David Rand , Gur Lubin , Marie Jakesova
CPC分类号： A61N1/0543 , A61N1/36046 , H10K30/20 , A61N1/0551 , A61N1/36062 , H10K85/311 , H10K85/621
摘要： An efficient nanoscale semiconducting optoelectronic system, containing a P/N acceptor donor organic hetrojunction which is optimized for neuronal stimulation—an organic electrolytic photocapacitor. The devices comprise a thin (80 nm) trilayer of metal and p-n semiconducting organic nanocrystals. When illuminated in physiological solution, these metal-semiconductor devices charge up, transducing light pulses into localized displacement currents that are strong enough to electrically stimulate neurons with safe light intensities.
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4.发明公开公开(公告)号：US20240282459A1
公开(公告)日：2024-08-22
申请号：US18566695
申请日：2021-06-04
CPC分类号： G16H50/50 , A61N1/36062 , G16H10/20 , G16H10/60 , G16H50/70
摘要： A system for predicting a spinal cord stimulation having a user interface for entry of features from a new patient and a machine learning engine having a cluster stage trained to evaluate the plurality of patient features to identify a cluster corresponding to the plurality of features of the patient from a plurality of clusters and a prediction stage trained to output a patient predicted outcome based a predictive model corresponding to the identified cluster. The plurality of features may comprise patient demographics, pain descriptors, pain questionnaire data, psychiatric comorbidities, spinal imaging, activity, medications, non-psychiatric comorbidities, and past spinal cord stimulation results.
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公开(公告)号：US20240278021A1
公开(公告)日：2024-08-22
申请号：US18651413
申请日：2024-04-30
发明人： Daran DeShazo , Gavin L. Rade
CPC分类号： A61N1/37235 , A61N1/37223 , A61N1/378 , A61B5/367 , A61N1/36038 , A61N1/36053 , A61N1/36062 , A61N1/36082 , A61N1/362 , A61N1/38 , A61N1/39622 , A61N2/006
摘要： An implantable medical device (IMO) includes one or more stimulation engines (SEs) and selectively connectable output switching circuitry for driving a plurality of output nodes associated with a respective plurality of electrodes of the IMO's lead system when implanted in a patient. The output switching circuitry may be configured to facilitate self-test mode (STM) functionality in the IMO (e.g., when it is in a hermetically sealed package) by using a dual mode switch in series with a stimulation engine selection switch with respect to each output node in the output switching circuitry under mode selection control.
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公开(公告)号：US20240261573A1
公开(公告)日：2024-08-08
申请号：US18427933
申请日：2024-01-31
申请人： Medtronic, Inc.
IPC分类号： A61N1/36
CPC分类号： A61N1/36062 , A61N1/36139 , A61N1/36146
摘要： Systems, devices, and methods for affecting a patient's kidney function by activating the reno-renal reflex via electrical stimulation of preganglionic dorsal root fibers using one or more electrodes placed proximate preganglionic dorsal root fibers of one or more dorsal roots at the T10 to L1 vertebrae of the patient's spinal cord.
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7.发明公开公开(公告)号：US20240226558A1
公开(公告)日：2024-07-11
申请号：US18612591
申请日：2024-03-21
CPC分类号： A61N1/36062 , A61N1/0551 , A61N1/36021 , A61N1/36071 , A61N1/36185 , A61N1/37247 , A61N1/06 , A61N1/36132 , A61N1/37235 , A61N1/37252
摘要： Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.
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公开(公告)号：US20240226556A1
公开(公告)日：2024-07-11
申请号：US18409366
申请日：2024-01-10
申请人： Wavegate Corporation
发明人： Erich W. Wolf, II
CPC分类号： A61N1/36062 , A61N1/025 , A61N1/36071 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/36178 , G16H40/63
摘要： This disclosure provides an SCS system comprised of an adaptive IPG. The IPG selectively chooses certain burst pulse parameters according to a pattern of frequencies and amplitudes that are determined by a low power hardware circuit. Alternatively, the patterns of frequencies and amplitudes are dictated by a predetermined list of parameters from a table of limited length. The IPG also is capable of receiving and storing vital sign telemetry, and spinal cord position to train an adaptive neural network to produce paresthesia pulses. Training of the IPG takes place after closing. Retraining the neural network allows the system to adapt to habituation, lead migration, and physiological changes in the patient's condition to maintain efficacy of the system over time. Training the neural network is also accomplished outside the IPG by a separate processor, which serves to conserve battery power and facilitate frequent retraining.
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公开(公告)号：US20240207611A1
公开(公告)日：2024-06-27
申请号：US18600006
申请日：2024-03-08
申请人： Spiro Medical, Inc.
发明人： Stephen T. Pyles
CPC分类号： A61N1/3601 , A61N1/0551 , A61N1/36062 , A61N1/36071 , A61N1/36171 , A61N1/36175
摘要： A kit for treating lung disease includes at least one lead having at least one contact, and a pulse generator configured to connect to the least one lead. The pulse generator is programmed to generate electrical signals for transmission through the at least one lead and for release by the at least one contact in a predetermined location of an epidural space to mitigate lung disease symptoms.
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公开(公告)号：US20240181257A1
公开(公告)日：2024-06-06
申请号：US18285068
申请日：2022-03-14
发明人： John Grimes , Vighnesh Rudra Das , Marcelo Baru , Brad McMillan , Linh Thuy Nguyen , Richard Yi Chen Tseng , David Genzer , Ashok Nedungadi
IPC分类号： A61N1/36
CPC分类号： A61N1/36062 , A61N1/36125 , A61N1/36153
摘要： The present disclosure provides a medical device (100) for electrical stimulation. The medical device (100) includes electric circuitry configured to perform active charge compensation, said electric circuitry being connectable to at least one electrode arrangement (102) for electrical stimulation. The electric circuitry includes monitoring means configured to monitor at least one voltage associated with a stimulation network (108, 116); at least one variable resistive element configured to provide an voltage drop used in the active charge compensation: and adjustment means configured to dynamically adjust a resistance value of the at least one variable resistive element during the active charge compensation based on the at least one monitored voltage, wherein the adjustment means (202) is a finite state machine for neurostimulation.
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