公开(公告)号：US20240307594A1

公开(公告)日：2024-09-19

申请号：US18606526

申请日：2024-03-15

Applicant: Boston Scientific Scimed, Inc.

Inventor： Jonathan Pascal Chaky ,  Ryan Lee Reifsteck ,  Aaron Cooper Foss ,  Nicholas Michael Job

IPC: A61L31/16 ,  A61L31/04

CPC classification number: A61L31/16 ,  A61L31/042 ,  A61L2300/216 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

Abstract: A medical device may be coated with a therapeutic composition that includes everolimus. Everolimus crystals may be coated with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition. The medical device may be contacted with the coating composition in order to form a coating on the medical device. Coating the everolimus crystals with a mixture of excipients to form encapsulated everolimus crystals suspended in a coating composition may include suspending everolimus crystals in a first solution that includes acetyl tri-butyl citrate (ATBC) and adding a second solution to the first solution, the second solution including ethyl cellulose (EC), the EC mixing with the ATBC and coating the everolimus crystals, thereby forming a coating suspension including coated everolimus crystals in the suspension.