公开(公告)号：US20240358892A1

公开(公告)日：2024-10-31

申请号：US18647746

申请日：2024-04-26

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Samuel Michael Hanson ,  Gary Thomas Ohrt ,  Sasha Viola Rios ,  Paul Vincent Grosso

IPC: A61L27/26 ,  A61L27/52

CPC classification number: A61L27/26 ,  A61L27/52 ,  A61L2400/06

Abstract: In some embodiments, the present disclosure pertains to an injectable shear-thinning composition that comprises (a) one or more types of polymers, (b) one or more types of microparticles and (c) water. In some embodiments, the present disclosure pertains to a kit that comprises (a) one or more containers that contain an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water and (b) a delivery device. In some embodiments, the present disclosure pertains to a medical procedure comprising administering to a subject an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water.

公开(公告)号：US20250043082A1

公开(公告)日：2025-02-06

申请号：US18781773

申请日：2024-07-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Yen-Hao Hsu ,  Sasha Viola Rios ,  Joseph Thomas Delaney, JR. ,  Rick Dorn ,  Cristian Parisi

IPC: C08J3/075 ,  A61K31/74 ,  A61K38/02 ,  C07K1/14 ,  C08G69/04

Abstract: In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.

公开(公告)号：US20240325594A1

公开(公告)日：2024-10-03

申请号：US18618262

申请日：2024-03-27

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Victoria Szlag ,  Paul Vincent Grosso ,  Samuel Michael Hanson ,  Sasha Viola Rios ,  Steven L. Kangas ,  Boxin Tang

IPC: A61L24/06 ,  A61L24/00

CPC classification number: A61L24/06 ,  A61L24/0015 ,  A61L2400/04 ,  A61L2400/06

Abstract: Aqueous liquid embolic compositions as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a hydrophobic monomer block and a charged (polycationic or polyanionic) block. The charged (polycationic or polyanionic) block may include one or more anions. The aqueous liquid embolic composition may also include templating agent.

公开(公告)号：US20250049964A1

公开(公告)日：2025-02-13

申请号：US18796777

申请日：2024-08-07

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Nicolas Ball-Jones ,  Sasha Viola Rios ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

IPC: A61K49/04

Abstract: In some aspects, the present disclosure pertains to an injectable hydrogel that comprises (a) one or more types of polymeric hydrogen bond donors, (b) one or more types of polymeric hydrogen bond acceptors and (c) water. Other aspects of the present disclosure pertain to kits that comprise a delivery device and one or more containers that contain an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water. Further aspects of the present disclosure pertain to medical procedures that comprise administering to a subject an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water.

公开(公告)号：US20240390527A1

公开(公告)日：2024-11-28

申请号：US18670474

申请日：2024-05-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Sasha Viola Rios ,  Nicolas Ball-Jones ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi

IPC: A61K49/04

Abstract: In some aspects the present disclosure provides a radiopaque, reactive copolymer comprising at least one hydrophilic polymer segment having a plurality of hydrophilic polymer segment ends, a plurality of iodinated polymer segments covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated polymer segments. In other aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, as well as to a crosslinked reaction product of the same. In further aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, under conditions such that the nucleophilic compound and the radiopaque, reactive copolymer crosslink after administration.