公开(公告)号：US20250017956A1

公开(公告)日：2025-01-16

申请号：US18762216

申请日：2024-07-02

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Rick Dorn ,  Cristian Parisi ,  Niraj Gurung ,  Claire Hobbs

IPC: A61K31/765 ,  A61K45/06 ,  C08J3/075 ,  C08K3/011

Abstract: Disclosed herein are radiopaque, reactive multi-arm polymers that comprise an iodine-containing core region, a plurality of polymer arms comprising a plurality of polymer segments linked to the iodine-containing core region, and a plurality of reactive moieties linked to the plurality of polymer segments. Also disclosed are methods of forming such radiopaque, reactive multi-arm polymers, systems for forming hydrogel compositions that comprise (a) such radiopaque, reactive multi-arm polymers and (b) multifunctional crosslinking compounds comprising a plurality of complementary reactive moieties that are reactive with the reactive moieties of the radiopaque, reactive multi-arm polymers, as well as reaction products of such systems and methods of treatment using such systems.

公开(公告)号：US20250043082A1

公开(公告)日：2025-02-06

申请号：US18781773

申请日：2024-07-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Nicolas Ball-Jones ,  Yen-Hao Hsu ,  Sasha Viola Rios ,  Joseph Thomas Delaney, JR. ,  Rick Dorn ,  Cristian Parisi

IPC: C08J3/075 ,  A61K31/74 ,  A61K38/02 ,  C07K1/14 ,  C08G69/04

Abstract: In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.

公开(公告)号：US20250032408A1

公开(公告)日：2025-01-30

申请号：US18781571

申请日：2024-07-23

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Cristian Parisi ,  Yen-Hao Hsu ,  Rick Dorn

IPC: A61K9/06 ,  A61K47/34 ,  A61L27/52 ,  C08G65/332 ,  C08G65/333

Abstract: In some aspects, the present disclosure provides reactive polymers that comprise one or more hydrophilic polymer segments having a plurality of hydrophilic polymer segment ends and a plurality of reactive moieties covalently linked to at least a portion of the hydrophilic polymer segment ends. The reactive moieties are 3,4-substituted-2,5-pyrrolidinedione moieties in which the 3-carbon and the 4-carbon form part of at least one ring in addition to the 2,5-pyrrolidinedione ring, and the 2,5-pyrrolidinedione ring nitrogen atom of each of the 3,4-substituted-2,5-pyrrolidinedione moieties is linked to one of the hydrophilic polymer segment ends. In other aspects, the present disclosure provides systems for forming hydrogel compositions and methods of treatment that employ such reactive polymers and methods of synthesizing such reactive polymers.

公开(公告)号：US20250019500A1

公开(公告)日：2025-01-16

申请号：US18763649

申请日：2024-07-03

Applicant: Boston Scientific Scimed, Inc.

Inventor： Rick Dorn ,  Joseph Thomas Delaney, JR.

IPC: C08J3/075 ,  A61L27/18 ,  A61L27/52 ,  A61L27/58 ,  C08K3/08

Abstract: The present disclosure pertains to systems for forming hydrogel compositions that comprise a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles, wherein the system is configured to deliver the reactive polymer and the gold nanoparticles under conditions such that covalent crosslinks are formed between the reactive polymer and the gold nanoparticles. The present disclosure also pertains to methods of treatment that comprise administering to a subject a mixture that comprises a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles, under conditions such that the reactive polymer and the gold nanoparticles crosslink after administration, and to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of first reactive moieties and gold nanoparticles.

公开(公告)号：US20250059237A1

公开(公告)日：2025-02-20

申请号：US18804679

申请日：2024-08-14

Applicant: Boston Scientific Scimed, Inc.

Inventor： Joseph Thomas Delaney, JR. ,  Rick Dorn ,  Yen-Hao Hsu ,  Cristian Parisi

IPC: C07K14/00 ,  C07K1/06 ,  C07K1/10 ,  C07K1/107

Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.