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公开(公告)号：US06270515B1
公开(公告)日：2001-08-07
申请号：US08805633
申请日：1997-02-26
IPC分类号： A61B1708
CPC分类号： A61L31/16 , A61B17/0057 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/00615 , A61L31/04 , A61L31/044 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2300/412 , A61L2300/414 , C08L85/02 , C08L67/04 , C08L75/04
摘要： A device for closing off a septal defect including a polymeric self-hardening material in a specific conformation which is delivered by a catheter means to the area of defect either directly on the cardiac tissue or into a balloon which spans both surfaces of the defect, and hardened in-situ by change in pH or ionic concentration, organic solvents, by permeation of a secondary material capable of precipitation, or by exposure to heat, light or laser energy. In blood, the device may be hardened through photopolymerization or a cooperative effect of coagulation, precipitation or ionization. The device can be made of biodegradable material impregnated with growth factors, mitogenic factors or other determinants which can improve tissue growth such that tissue ingrowth can occur over a period of time. The catheter itself may be an ultrasonic imaging catheter.
摘要翻译： 一种用于闭合中隔缺损的装置，其包括特定构象中的聚合物自硬化材料，其通过导管装置直接在心脏组织或跨越缺损的两个表面的气囊中传递到缺陷区域;以及 通过pH或离子浓度的变化，有机溶剂，能够沉淀的二次材料的渗透，或通过暴露于热，光或激光能量而原位硬化。 在血液中，可以通过光聚合或凝结，沉淀或离子化的协同作用使装置硬化。 该装置可以由浸有生长因子，促有丝分裂因子或其他决定因素的可生物降解材料制成，其可以改善组织生长，使得组织向内生长可以在一段时间内发生。 导管本身可以是超声成像导管。
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公开(公告)号：US5634936A
公开(公告)日：1997-06-03
申请号：US383824
申请日：1995-02-06
CPC分类号： A61L31/16 , A61B17/0057 , A61L31/04 , A61L31/044 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/00615 , A61L2300/412 , A61L2300/414
摘要： A device for closing off a septal defect including a polymeric self-hardening material in a specific conformation which is delivered by a catheter device to the area of defect either directly on the cardiac tissue or into a balloon which spans both surfaces of the defect, and hardened in-situ by change in pH or ionic concentration, organic solvents, by permeation of a secondary material capable of precipitation, or by exposure to heat, light or laser energy. In blood, the device may be hardened through photopolymerization or a cooperative effect of coagulation, precipitation or ionization. The device can be made of biodegradable material impregnated with growth factors, mitogenic factors or other determinants which can improve tissue growth such that tissue ingrowth can occur over a period of time. The catheter itself may be an ultrasonic imaging catheter.
摘要翻译： 一种用于闭合中隔缺损的装置，其包括特定构象的聚合物自硬化材料，其通过导管装置直接在心脏组织或横跨缺损的两个表面的气球中传送到缺陷区域;以及 通过pH或离子浓度的变化，有机溶剂，能够沉淀的二次材料的渗透，或通过暴露于热，光或激光能量而原位硬化。 在血液中，可以通过光聚合或凝结，沉淀或离子化的协同作用使装置硬化。 该装置可以由浸有生长因子，促有丝分裂因子或其他决定因素的可生物降解材料制成，其可以改善组织生长，使得组织向内生长可以在一段时间内发生。 导管本身可以是超声成像导管。
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