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公开(公告)号：US20060014761A1
公开(公告)日：2006-01-19
申请号：US11155940
申请日：2005-06-16
申请人： Bradley Morgan , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto , David Morgans
发明人： Bradley Morgan , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto , David Morgans
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/42 , A61K31/40 , C07D413/02 , C07D403/02
CPC分类号： C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US20050159416A1
公开(公告)日：2005-07-21
申请号：US10890829
申请日：2004-07-14
申请人： Bradley Morgan , Kathleen Elias , Erica Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Smith , Todd Tochimoto , Adam Tomasi , David Morgans
发明人： Bradley Morgan , Kathleen Elias , Erica Kraynack , Pu-Ping Lu , Fady Malik , Alex Muci , Xiangping Qian , Whitney Smith , Todd Tochimoto , Adam Tomasi , David Morgans
IPC分类号： A61K20060101 , A61K31/17 , A61K31/34 , A61K31/35 , A61K31/424 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/5377 , C07C273/02 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/02 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/02 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04 , C07D41/02 , C07D43/02 , C07D45/02
CPC分类号： A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20070066626A1
公开(公告)日：2007-03-22
申请号：US11498986
申请日：2006-08-04
申请人： Bradley Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David Morgans
发明人： Bradley Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David Morgans
IPC分类号： A61K31/506 , A61K31/497 , A61K31/4545 , A61K31/4439 , C07D403/02 , C07D401/02
CPC分类号： C07D417/12 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20070208000A1
公开(公告)日：2007-09-06
申请号：US11639380
申请日：2006-12-13
申请人： Bradley Morgan , Pu-Ping Lu , Alex Muci , Erica Kraynack , Todd Tochimoto , David Morgans
发明人： Bradley Morgan , Pu-Ping Lu , Alex Muci , Erica Kraynack , Todd Tochimoto , David Morgans
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D413/12 , C07D471/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译： 某些取代的脲衍生物选择性地调节心肌肉瘤，例如通过增强心肌肌球蛋白，并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号：US20070197504A1
公开(公告)日：2007-08-23
申请号：US11639398
申请日：2006-12-13
申请人： Bradley Morgan , Alex Muci , Erica Kraynack , Todd Tochimoto , Pu-Ping Lu , David Morgans
发明人： Bradley Morgan , Alex Muci , Erica Kraynack , Todd Tochimoto , Pu-Ping Lu , David Morgans
IPC分类号： A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/501 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D401/12 , C07D213/75 , C07D239/42 , C07D261/14 , C07D403/12 , C07D413/12
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US20070161617A1
公开(公告)日：2007-07-12
申请号：US11640438
申请日：2006-12-14
申请人： Bradley Morgan , David Morgans , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto
发明人： Bradley Morgan , David Morgans , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4965
CPC分类号： C07D213/75 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US20070197497A1
公开(公告)日：2007-08-23
申请号：US11640476
申请日：2006-12-14
申请人： Bradley Morgan , David Morgans , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto
发明人： Bradley Morgan , David Morgans , Alex Muci , Pu-Ping Lu , Erica Kraynack , Todd Tochimoto
IPC分类号： A61K31/496 , C07D403/14 , C07D403/02
CPC分类号： C07D213/75 , C07D261/14 , C07D401/12 , C07D401/14 , C07D413/12
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US20070197507A1
公开(公告)日：2007-08-23
申请号：US11639390
申请日：2006-12-13
申请人： Bradley Morgan , Erica Kraynack , Pu-Ping Lu , Alex Muci , David Morgans
发明人： Bradley Morgan , Erica Kraynack , Pu-Ping Lu , Alex Muci , David Morgans
IPC分类号： A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/498 , C07D487/04
CPC分类号： C07D413/12 , C07D213/75 , C07D295/13 , C07D295/145 , C07D401/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US07538223B2
公开(公告)日：2009-05-26
申请号：US11498986
申请日：2006-08-04
申请人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
发明人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号： C07D211/68 , C07D401/00 , C07D459/00
CPC分类号： C07D417/12 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号：US07910743B2
公开(公告)日：2011-03-22
申请号：US12469603
申请日：2009-05-20
申请人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
发明人： Bradley P. Morgan , Alex Muci , Erica Kraynack , Pu-Ping Lu , Todd Tochimoto , David J. Morgans, Jr.
IPC分类号： C07D211/68 , C07D401/04 , C07D401/14
CPC分类号： C07D417/12 , C07D513/04
摘要： Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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