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17 条记录 (耗时 0.054 秒)

    Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
    5.
    发明授权
    Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto 有权
    作为可用于治疗与其相关的疾病的5-HT2A 5-羟色胺受体的调节剂的伯胺及其衍生物

    公开(公告)号：US08664258B2

    公开(公告)日：2014-03-04

    申请号：US13417028

    申请日：2012-03-09

    申请人： Bradley Teegarden ,  Dennis Chapman ,  Juyi Choi ,  Konrad Feichtinger ,  Sangdon Han ,  Honnappa Jayakumar ,  Thuy-Anh Tran ,  Jay Xu ,  Ning Zou

    发明人： Bradley Teegarden ,  Dennis Chapman ,  Juyi Choi ,  Konrad Feichtinger ,  Sangdon Han ,  Honnappa Jayakumar ,  Thuy-Anh Tran ,  Jay Xu ,  Ning Zou

    IPC分类号： A61K31/415 ,  C07D231/00

    CPC分类号： A61K31/415 ,  C07D231/12 ,  C07D231/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.

    摘要翻译： 本发明涉及某些调节5-HT2A 5-羟色胺受体活性的式（Ia）化合物及其药物组合物。 化合物及其药物组合物涉及可用于治疗血小板凝集，冠状动脉疾病，心肌梗塞，短暂性脑缺血发作，心绞痛，中风，心房颤动，血块形成，哮喘或其症状，躁动或其症状的方法， 精神病，精神病，急性精神分裂症，慢性精神分裂症，精神分裂症精神分裂症和相关疾病，睡眠障碍，睡眠障碍，糖尿病性精神病，精神病，精神病， 相关疾病，进行性多灶性脑白质病等。 本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT2A 5-羟色胺受体相关疾病的方法。

    Process for rendering a surface biocompatible, and articles containing the same
    9.
    发明授权
    Process for rendering a surface biocompatible, and articles containing the same 失效
    用于使表面生物相容的方法，以及含有该表面的制品

    公开(公告)号：US5380904A

    公开(公告)日：1995-01-10

    申请号：US169641

    申请日：1993-12-20

    申请人： Dennis Chapman ,  Aziz A. Durrani

    发明人： Dennis Chapman ,  Aziz A. Durrani

    IPC分类号： A61L33/00 ,  C07C43/315 ,  C07F5/00 ,  C07F9/09 ,  C07F9/6584 ,  C07F9/146 ,  A01N1/02 ,  B01J16/00 ,  C07F9/10

    CPC分类号： C07F9/65844 ,  A61L33/0082 ,  C07C43/315 ,  C07F5/003 ,  C07F9/091 ,  Y10S128/912

    摘要： A compound of formula: ##STR1## in which X.sup.1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X.sup.2 is a group --O.sup..crclbar. or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup..sym. R.sub.3 A.sup..crclbar. wherein each R, which may be the same or different, is a C.sub.1 -C.sub.4 alkyl group and A.sup..crclbar. is an anion present when X.sup.2 is an electrically neutral group or Y is ##STR2## wherein R.sup.1 together with X.sup.2 forms a direct bond between the nitrogen and the phosphorus atoms.

    摘要翻译： 下式的化合物：其中X1是能与反应性基团反应形成与要生物相容的材料的表面上的反应性基团的反应性基团，X 2是基团-O（ - ）或 这种基团的前体，n为2,3或4，Y为-N（+）R 3A（ - ）基团，其中各R可以相同或不同，为C1-C4烷基，A（ - ）是当X2是电中性基团时存在的阴离子或Y是其中R 1与X 2一起形成氮和磷原子之间的直接键。

    Article having biocompatible surface
    10.
    发明授权
    Article having biocompatible surface 失效
    物品具有生物相容性表面

    公开(公告)号：US5229162A

    公开(公告)日：1993-07-20

    申请号：US789894

    申请日：1991-11-12

    申请人： Dennis Chapman ,  Aziz A. Durrani

    发明人： Dennis Chapman ,  Aziz A. Durrani

    IPC分类号： A61L33/00 ,  C07C43/315 ,  C07F5/00 ,  C07F9/09 ,  C07F9/6584

    CPC分类号： C07F9/65844 ,  A61L33/0082 ,  C07C43/315 ,  C07F5/003 ,  C07F9/091 ,  Y10S128/912 ,  Y10S525/937 ,  Y10S623/924 ,  Y10T428/1352

    摘要： A compound of formula: ##STR1## in which X.sup.1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X.sup.2 is a group -O.sup..crclbar. or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup..sym. R.sub.3 A.sup..crclbar. wherein each R, which may be the same or different, is a C.sub.1 -C.sub.4 alkyl group and A.sup..crclbar. is an anion present when X.sup.2 is an electrically neutral group or Y is ##STR2## wherein R.sup.1 together with X.sup.2 forms a direct bond between the nitrogen and the phosphorus atoms.

    摘要翻译： 下式的化合物：其中X1是能与反应性基团反应形成与要生物相容的材料的表面上的反应性基团的反应性基团，X 2是基团-O（ - ）或 这种基团的前体，n为2,3或4，Y为-N（+）R 3A（ - ）基团，其中各R可以相同或不同，为C1-C4烷基，A（ - ）是当X2是电中性基团时存在的阴离子或Y是其中R 1与X 2一起形成氮和磷原子之间的直接键。