公开(公告)号：US08044996B2

公开(公告)日：2011-10-25

申请号：US11429420

申请日：2006-05-04

申请人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

发明人： Bradley W. Rice ,  Heng Xu ,  Chaincy Kuo

IPC分类号： H04N13/02 ,  G06K9/00 ,  G01B11/24

CPC分类号： A61B5/1077 ,  A61B5/0059 ,  A61B5/1079 ,  G01B11/25 ,  G01N21/532 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/6439 ,  G06T7/521

摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.

摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。

公开(公告)号：US07599731B2

公开(公告)日：2009-10-06

申请号：US11733358

申请日：2007-04-10

申请人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

发明人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

IPC分类号： A61B6/03 ,  A61B6/12

CPC分类号： A61B5/0073 ,  G01N21/49 ,  G01N2021/1787 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439

摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

摘要翻译： 本文描述了用于获得样品（例如哺乳动物）内荧光探针分布的三维（3D）表示的系统和方法。 使用a）来自一个或多个图像的荧光发射数据，b）哺乳动物的表面表示，以及c）计算机实现的光子传播模型，所述系统和方法在哺乳动物中产生荧光探针分布的3D表示。 分布可以指示 - 哺乳动物中一种或多种荧光探针的位置，大小和/或亮度或浓度。

公开(公告)号：US07555332B2

公开(公告)日：2009-06-30

申请号：US11829927

申请日：2007-07-29

申请人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

发明人： Bradley W. Rice ,  Chaincy Kuo ,  Daniel G. Stearns ,  Heng Xu

IPC分类号： A61B6/03 ,  A61B6/12

CPC分类号： A61B5/0073 ,  G01N21/49 ,  G01N2021/1787 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439

摘要： Described herein are systems and methods for obtaining a three-dimensional (3D) representation of the distribution of fluorescent probes inside a sample, such as a mammal. Using a) fluorescent light emission data from one or more images, b) a surface representation of the mammal, and c) computer-implemented photon propagation models, the systems and methods produce a 3D representation of the fluorescent probe distribution in the mammal. The distribution may indicate—in 3D—the location, size, and/or brightness or concentration of one or more fluorescent probes in the mammal.

公开(公告)号：US20060268153A1

公开(公告)日：2006-11-30

申请号：US11429420

申请日：2006-05-04

申请人： Bradley Rice ,  Heng Xu ,  Chaincy Kuo

发明人： Bradley Rice ,  Heng Xu ,  Chaincy Kuo

IPC分类号： H04N5/222

CPC分类号： A61B5/1077 ,  A61B5/0059 ,  A61B5/1079 ,  G01B11/25 ,  G01N21/532 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/6439 ,  G06T7/521

摘要： The invention relates to topographic construction that combines photographic and structured light information. The dual modality construction acquires structured light information for an object and photographic images from multiple views about the object. Topographic construction then processes the structured light information and photographic data in the multiple images to generate a surface representation of the object in each modality. The photographic and structured light surface representations are then combined to output a dual modality surface topography.

摘要翻译： 本发明涉及结合照相和结构光信息的地形构造。 双重模式结构从物体的多个视图中获取物体的结构光信息和摄影图像。 然后，地形构造处理多个图像中的结构光信息和摄影数据，以在每个模态中生成对象的表面表示。 然后将照相和结构化的光表面表示组合以输出双模态表面形貌。

公开(公告)号：US10335038B2

公开(公告)日：2019-07-02

申请号：US11844920

申请日：2007-08-24

申请人： Heng Xu ,  Bradley W. Rice

发明人： Heng Xu ,  Bradley W. Rice

IPC分类号： G01N21/64 ,  G01N21/25 ,  A61B5/00

摘要： Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.

公开(公告)号：US08000775B2

公开(公告)日：2011-08-16

申请号：US12088845

申请日：2006-04-27

申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

IPC分类号： A61B6/00

CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

公开(公告)号：US20090247847A1

公开(公告)日：2009-10-01

申请号：US12088845

申请日：2006-04-27

申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

IPC分类号： A61B6/03 ,  A61B5/1455

CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

公开(公告)号：US20080051665A1

公开(公告)日：2008-02-28

申请号：US11844920

申请日：2007-08-24

申请人： Heng Xu ,  Bradley Rice

发明人： Heng Xu ,  Bradley Rice

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B2503/40 ,  G01N21/6428 ,  G01N21/6456

摘要： Described herein are systems and methods for spectral unmixing of in vivo light data. The spectral unmixing separates image data according to spectra from multiple internal light sources in an effort to isolate one or more spectrum of interest. The spectral unmixing obtains images with a combination of different and known excitation and emission limits. The spectral unmixing then uses an iterative solution process to separate spectra for the multiple fluorescent light sources, and provides a spectrum and/or a spatial distribution map for at least one of the internal light sources.

摘要翻译： 本文描述了用于体内光数据的光谱解混合的系统和方法。 光谱解混合根据来自多个内部光源的光谱分离图像数据，以分离一个或多个感兴趣的光谱。 光谱解混合获得具有不同和已知的激发和发射限制的组合的图像。 然后，光谱解混合使用迭代解法来分离多个荧光光源的光谱，并为至少一个内部光源提供光谱和/或空间分布图。

公开(公告)号：US20120101134A1

公开(公告)日：2012-04-26

申请号：US13379431

申请日：2010-06-24

申请人： Guanghui Deng ,  Xichen Lin ,  Qinghua Meng ,  Feng Ren ,  Jia-Ning Xiang ,  Heng Xu ,  Haibo Zhang ,  Baowei Zhao

发明人： Guanghui Deng ,  Xichen Lin ,  Qinghua Meng ,  Feng Ren ,  Jia-Ning Xiang ,  Heng Xu ,  Haibo Zhang ,  Baowei Zhao

IPC分类号： A61K31/4439 ,  C07D413/04 ,  C07D271/107 ,  C07D285/12 ,  C07D285/08 ,  C07D277/30 ,  C07D417/04 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/426 ,  A61P25/00 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P17/06 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P31/12 ,  A61P3/10 ,  C07D271/06

CPC分类号： C07D263/32 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  C07D271/06 ,  C07D271/10 ,  C07D271/107 ,  C07D277/22 ,  C07D277/28 ,  C07D277/30 ,  C07D285/08 ,  C07D285/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

摘要翻译： 公开了式（I）的5元杂芳基衍生物或其盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。

公开(公告)号：US20100056776A1

公开(公告)日：2010-03-04

申请号：US12513813

申请日：2007-11-06

申请人： Martin W. Brechbiel ,  Heng Xu

发明人： Martin W. Brechbiel ,  Heng Xu

IPC分类号： C07D403/12 ,  C07C229/00 ,  C07D207/46 ,  C07D207/40 ,  C07D257/02

CPC分类号： A61K51/065 ,  A61K47/59 ,  A61K47/595 ,  A61K49/085 ,  A61K49/124

摘要： Disclosed are methods of preparing a macromolecular conjugated ligand and a metal complex thereof. The metal complex is targeted for use as a contrast agent, for example, in MRI. The method of preparing a macromolecular conjugated ligand comprises: (a) providing a compound of formula (I) wherein R, A, and Pg are as defined herein, (b) reacting the compound of formula (I) with a macromolecular compound (e.g., dendrimer) in an organic solvent medium which is substantially free of water to obtain a macromolecular conjugated compound, and (c) removing the carboxyl-protecting groups to obtain a carboxyl-deprotected macromolecular conjugated compound. The metal complex can be prepared by reacting the carboxyl-deprotected macromolecular conjugated compound with an ion (e.g., Gd(III)). Also disclosed are two carboxyl-protected 1B4M-DTPA intermediate compounds.

摘要翻译： 公开了制备大分子共轭配体及其金属络合物的方法。 金属络合物被靶向用作造影剂，例如在MRI中。 制备大分子缀合配体的方法包括：（a）提供其中R，A和Pg如本文所定义的式（I）化合物，（b）使式（I）化合物与高分子化合物 树枝状大分子）在基本上不含水的有机溶剂介质中，得到高分子共轭化合物，（c）除去羧基保护基，得到羧基脱保护的高分子共轭化合物。 金属络合物可以通过羧基脱保护的大分子共轭化合物与离子（例如Gd（III））反应来制备。 还公开了两种羧基保护的1B4M-DTPA中间体化合物。