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    Systems and methods for tomographic image reconstruction
    1.
    发明授权
    Systems and methods for tomographic image reconstruction 有权
    断层图像重建的系统和方法

    公开(公告)号：US08000775B2

    公开(公告)日：2011-08-16

    申请号：US12088845

    申请日：2006-04-27

    申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

    摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

    摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION
    2.
    发明申请
    SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION 有权
    用于图像图像重构的系统和方法

    公开(公告)号：US20090247847A1

    公开(公告)日：2009-10-01

    申请号：US12088845

    申请日：2006-04-27

    申请人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    发明人： Brian William Pogue ,  Daqing Piao ,  Keith D. Paulsen ,  Shudong Jiang ,  Hamid Dehghani ,  Heng Xu ,  Roger Springett ,  Subhadra Srinivasan

    IPC分类号： A61B6/03 ,  A61B5/1455

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

    摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.

    摘要翻译： 描述了从多个源提供多个不同波长的光的光学层析成像系统。 系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。 图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。 光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。 系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

    Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy
    3.
    发明申请
    Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy 有权
    脉冲激光器在频域漫射光学层析成像和光谱学中的应用

    公开(公告)号：US20100265493A1

    公开(公告)日：2010-10-21

    申请号：US12665518

    申请日：2008-06-20

    申请人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

    发明人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

    IPC分类号： G01N21/47 ,  G01N21/00 ,  G01J3/00

    CPC分类号： G01N21/4795 ,  A61B5/0073

    摘要： A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.

    摘要翻译： 结合锁模的可调谐激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。 检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。 描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

    Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy
    4.
    发明授权
    Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy 有权
    脉冲激光器在频域扩散光学断层扫描和光谱学

    公开(公告)号：US08634082B2

    公开(公告)日：2014-01-21

    申请号：US12665518

    申请日：2008-06-20

    申请人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

    发明人： Shudong Jiang ,  Brian William Pogue ,  Jia Wang ,  Keith D. Paulsen

    IPC分类号： G01B9/02

    CPC分类号： G01N21/4795 ,  A61B5/0073

    摘要： A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.

    摘要翻译： 结合锁模的可调谐激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。 检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。 描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

    System and method for spectral-encoded high-rate hemodynamic tomography
    6.
    发明授权
    System and method for spectral-encoded high-rate hemodynamic tomography 有权
    用于频谱编码的高速血流动力学断层扫描的系统和方法

    公开(公告)号：US07962198B2

    公开(公告)日：2011-06-14

    申请号：US11115865

    申请日：2005-04-27

    申请人： Brian William Pogue ,  Daqing Piao

    发明人： Brian William Pogue ,  Daqing Piao

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14551 ,  A61B5/4312 ,  A61B5/7239

    摘要： An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at laser-specific locations on the tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the laser-specific locations on the tissue and the reception points. Image construction apparatus generates a tomographic image of heme concentrations in the mammalian tissue from the path attenuation signals. In an alternative embodiment, there is a second group of lasers operating in a second wavelength band, and the image construction apparatus can generate an image of heme oxygenation In the mammalian tissue.

    摘要翻译： 光学断层摄影系统具有用于在第一波长带内产生多个不同波长的光的一组激光器。 来自这些激光器的光被引导到组织上的激光特定位置处的哺乳动物组织中，并且来自哺乳动物组织的光在多个接收点被收集。 来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收，以产生表示沿着组织上的激光器特定位置和接收点之间的路径衰减的路径衰减信号。 图像构造装置从路径衰减信号生成哺乳动物组织中血红素浓度的断层图像。 在替代实施例中，存在在第二波长带中操作的第二组激光器，并且图像构建装置可以在哺乳动物组织中产生血红素氧合图像。

    Operative microscope having diffuse optical imaging system with tomographic image reconstruction and superposition in field of view
    8.
    发明授权
    Operative microscope having diffuse optical imaging system with tomographic image reconstruction and superposition in field of view 有权
    具有扩散光学成像系统的手术显微镜，具有断层图像重建和视野叠加

    公开(公告)号：US09254103B2

    公开(公告)日：2016-02-09

    申请号：US13586558

    申请日：2012-08-15

    申请人： Venkataramanan Krishnaswamy ,  Brian William Pogue

    发明人： Venkataramanan Krishnaswamy ,  Brian William Pogue

    IPC分类号： H04N13/00 ,  A61B5/00 ,  A61B19/00 ,  G02B21/36 ,  H04N13/02 ,  A61B5/1455

    CPC分类号： A61B5/0042 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/14553 ,  A61B5/7257 ,  A61B90/20 ,  A61B2090/366 ,  G02B21/365 ,  H04N13/239

    摘要： An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model.

    摘要翻译： 成像系统具有具有物镜的显微镜和投影装置，该投影装置被配置为将经空间调制的光以几种预先选定的预定图案中的一种投影通过物镜投影到组织上。 所述系统照相机被配置为通过由空间调制光照射的显微镜和物镜记录组织的图像，以及具有存储器的图像处理器，该存储器具有用于对组织的图像进行空间傅立叶分析以恢复空间频率 。 图像处理器还构建组织的三维模型，并且对模型的体素的至少吸光度和散射参数进行拟合以匹配恢复的空间频率。 然后处理器显示三维模型的断层图像。

    Operative Microscope Having Diffuse Optical Imaging System With Tomographic Image Reconstruction And Superposition In Field Of View
    10.
    发明申请
    Operative Microscope Having Diffuse Optical Imaging System With Tomographic Image Reconstruction And Superposition In Field Of View 有权
    具有漫射光学成像系统的手术显微镜与视野中的断层图像重建和叠加

    公开(公告)号：US20130044185A1

    公开(公告)日：2013-02-21

    申请号：US13586558

    申请日：2012-08-15

    申请人： Venkataramanan Krishnaswamy ,  Brian William Pogue

    发明人： Venkataramanan Krishnaswamy ,  Brian William Pogue

    IPC分类号： H04N13/00

    CPC分类号： A61B5/0042 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/14553 ,  A61B5/7257 ,  A61B90/20 ,  A61B2090/366 ,  G02B21/365 ,  H04N13/239

    摘要： An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model.

    摘要翻译： 成像系统具有具有物镜的显微镜和投影装置，该投影装置被配置为将经空间调制的光以几种预先选定的预定图案中的一种投影通过物镜投影到组织上。 所述系统照相机被配置为通过由空间调制光照射的显微镜和物镜记录组织的图像，以及具有存储器的图像处理器，该存储器具有用于对组织的图像进行空间傅立叶分析以恢复空间频率的程序 。 图像处理器还构建组织的三维模型，并且对模型的体素的至少吸光度和散射参数进行拟合以匹配恢复的空间频率。 然后处理器显示三维模型的断层图像。