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公开(公告)号:US20120028924A1
公开(公告)日:2012-02-02
申请号:US13196189
申请日:2011-08-02
申请人: Brian AQUILA , Victor KAMHI , Bo PENG , Timothy PONTZ , Jamal Carlos SAEH , Kumar THAKUR , Bin YANG
发明人: Brian AQUILA , Victor KAMHI , Bo PENG , Timothy PONTZ , Jamal Carlos SAEH , Kumar THAKUR , Bin YANG
IPC分类号: A61K31/506 , A61K31/675 , A61P35/00 , C07D405/14 , C07D413/14 , A61K31/5377 , C07D401/14 , C07F9/6584
CPC分类号: C07D401/14 , C07F9/65685
摘要: The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the treatment of cancer.
摘要翻译: 本发明涉及式(I)和/或式(Ia)化合物及其盐,药物组合物,使用方法及其制备方法。 这些化合物抑制ALK激酶活性,因此可用于治疗癌症。
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公开(公告)号:US20110311483A1
公开(公告)日:2011-12-22
申请号:US13074995
申请日:2011-03-29
申请人: James JIA , Regina GRAUL , Bo PENG , Colleen HUDSON , Joel MOORE , Ara MERMERIAN
发明人: James JIA , Regina GRAUL , Bo PENG , Colleen HUDSON , Joel MOORE , Ara MERMERIAN
IPC分类号: A61K31/5377 , C07D209/02 , C07D401/12 , A61K31/403 , A61K31/454 , C07D403/12 , A61P11/06 , A61P17/00 , A61P11/02 , A61P37/08 , A61P5/14 , A61P11/14 , A61P11/08 , A61P11/00 , A61P27/02 , A61P3/00 , A61P19/02 , A61P29/00 , A61P17/06 , A61P19/04 , A61P1/00 , A61P37/06 , A61P25/00 , A61P3/10 , A61P7/02 , A61P9/10 , A61P15/02 , A61P7/00 , A61P35/02 , A61K39/395 , A61K31/573 , A61K38/21 , A61K33/24 , A61K31/606 , C07D413/12
CPC分类号: A61K31/5377 , A61K31/403 , A61K31/454 , A61K45/06 , C07D209/10 , C07D209/12 , A61K2300/00
摘要: Compounds of Formulae I-1 to I-9 are disclosed, which are modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders.
摘要翻译: 公开了式I-1至I-9的化合物,其是CRTH2的调节剂,特别是CRTH2的拮抗剂,其可用于治疗各种疾病,包括哮喘和呼吸障碍。
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公开(公告)号:US20210049689A1
公开(公告)日:2021-02-18
申请号:US16581785
申请日:2019-09-25
申请人: Bo PENG
发明人: Bo PENG
摘要: A stock price estimation method, apparatus, and device. The method comprises: obtaining current tick data of a stock, wherein the current tick data comprises N best prices and corresponding buy/sell volumes of the stock, where N is a positive integer greater than 1; determining, by using money to be invested or money to be withdrawn and the current tick data, a final transaction price if all the money to be invested is used to buy the stock or all the money to be withdrawn is obtained by selling the stock; and presenting the final transaction price in real time for an investor's reference. By means of the stock price estimation method provided in the embodiments of the present invention, the fluctuation of a final price of a stock under the impact of a particular amount of money can be calculated by using current tick information.
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