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    MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS
    8.
    发明申请
    MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS 有权
    大肠杆菌C型病毒丝氨酸蛋白酶抑制剂

    公开(公告)号：US20080008681A1

    公开(公告)日：2008-01-10

    申请号：US11768712

    申请日：2007-06-26

    申请人： Deqiang Niu ,  Dong Liu ,  Joel Moore ,  Guoyou Xu ,  Ying Sun ,  Yonghua Gai ,  Datong Tang ,  Yat Sun Or ,  Zhe Wang

    发明人： Deqiang Niu ,  Dong Liu ,  Joel Moore ,  Guoyou Xu ,  Ying Sun ,  Yonghua Gai ,  Datong Tang ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/21 ,  A61K31/498 ,  A61P31/12 ,  C07D245/04

    CPC分类号： C07D245/04 ,  A61K38/212 ,  A61K38/215 ,  C07D403/12 ,  A61K2300/00

    摘要： The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明涉及包括式I化合物或其药学上可接受的盐，酯或前药的化合物，其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Fire safety device for propane cylinders
    9.
    发明申请
    Fire safety device for propane cylinders 失效
    丙烷气瓶消防安全装置

    公开(公告)号：US20050217725A1

    公开(公告)日：2005-10-06

    申请号：US11093881

    申请日：2005-03-30

    申请人： Joel Moore ,  Gregory Reitsma ,  Robert Jones

    发明人： Joel Moore ,  Gregory Reitsma ,  Robert Jones

    IPC分类号： F16K17/38

    CPC分类号： F16K17/383 ,  Y10T137/1812 ,  Y10T137/1819

    摘要： A fire safety fluid flow device for engagement with a Schrader valve including a sliding valve a housing having a fluid path therethrough and a pressing member. The pressing member presses against the sliding valve of the Schrader valve when engaged therewith to allow fluid flow through the Schrader valve. The pressing member continues to maintain the sliding valve in an open position when the device is below a predetermined temperature and connected to the Schrader valve. The pressing member is configured to no longer press against the sliding valve of the Schrader valve at and above the predetermined temperature to allow the sliding valve of the Schrader valve to thereby stop fluid flow through the Schrader valve.

    摘要翻译： 一种消防安全流体流动装置，用于与包括滑阀的施拉德阀接合，该壳体具有穿过其中的流体通道的壳体和按压构件。 按压构件在与其接合时压靠Schrader阀的滑阀，以允许流体流过Schrader阀。 当装置低于预定温度并且连接到施拉德阀时，按压构件继续将滑阀保持在打开位置。 按压构件被构造成在预定温度以上不再压入Schrader阀的滑阀，以允许施拉德阀的滑阀阻止流体流过施拉德阀。

    Apparatus for preparing food
    10.
    发明申请
    Apparatus for preparing food 审中-公开
    食物准备设备

    公开(公告)号：US20050172949A1

    公开(公告)日：2005-08-11

    申请号：US11054223

    申请日：2005-02-09

    申请人： Joel Moore ,  Craig Walther ,  Charles Olds ,  Brian Yutzy ,  Mark Hood ,  Robert Jones ,  Edward Lee

    发明人： Joel Moore ,  Craig Walther ,  Charles Olds ,  Brian Yutzy ,  Mark Hood ,  Robert Jones ,  Edward Lee

    IPC分类号： A47J27/00 ,  A47J27/026 ,  A47J37/12

    CPC分类号： A47J37/1242 ,  A47J37/1247

    摘要： A cooking apparatus for preparing food includes a vessel, a burner, an electrically controllable valve, a thermocouple and a thermally actuated switch. The vessel is configured for containing a fluid and the burner is positioned for providing a gas flame to the vessel. The valve is coupled between the burner and a gas source and the thermocouple is positioned to sense a temperature of the flame provided by the burner. The thermally actuated switch is serially coupled between the valve and the thermocouple. The switch provides a conduction path between the valve and the thermocouple, when a temperature sensed by the thermal switch is less than a predetermined temperature. The switch is integrally mounted to the vessel to sense a temperature of the fluid contained within the vessel.

    摘要翻译： 用于制备食物的烹饪设备包括容器，燃烧器，电可控阀，热电偶和热致动开关。 容器构造成容纳流体，并且燃烧器被定位成为容器提供气体火焰。 阀连接在燃烧器和气体源之间，并且热电偶被定位成感测由燃烧器提供的火焰的温度。 热致动开关串联在阀和热电偶之间。 当热开关感测的温度小于预定温度时，开关提供阀和热电偶之间的传导路径。 开关整体地安装到容器以感测容纳在容器内的流体的温度。