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    HEAT STABLE NANOPARTICLE PREPARATIONS AND ASSOCIATED METHODS THEREOF
    2.
    发明申请
    HEAT STABLE NANOPARTICLE PREPARATIONS AND ASSOCIATED METHODS THEREOF 有权
    热稳定的纳米材料制备及其相关方法

    公开(公告)号：US20140003997A1

    公开(公告)日：2014-01-02

    申请号：US13538493

    申请日：2012-06-29

    申请人： Brian Christopher Bales ,  Brian James Grimmond ,  Daniel Eugene Meyer ,  Bruce Allan Hay ,  Michael Todd Luttrell

    发明人： Brian Christopher Bales ,  Brian James Grimmond ,  Daniel Eugene Meyer ,  Bruce Allan Hay ,  Michael Todd Luttrell

    IPC分类号： A61L2/04 ,  B82Y5/00 ,  B82Y40/00

    CPC分类号： H01F1/0054 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

    摘要： A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

    摘要翻译： 提供了一种在高温下对纳米颗粒制剂进行灭菌的方法。 纯化多个纳米颗粒以形成制剂，其中所述纳米颗粒至少包含核和壳，并且所述壳包含连接到核的一种或多种配体物质。 纳米颗粒制备由纯化的纳米颗粒组合物，载体流体和过量的未连接到核的一种或多种配体物质制备。 在核心附着的配体物质和纯化后加入的过量配体物质在结构上是相同的。 本发明提供的纳米颗粒制剂可用作医学成像技术如X射线和磁共振成像中的造影剂。

    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells
    3.
    发明授权
    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells 有权
    具有PEG取代的α-羟基膦酸酯壳的超顺磁性纳米颗粒

    公开(公告)号：US09474810B2

    公开(公告)日：2016-10-25

    申请号：US13411004

    申请日：2012-03-02

    申请人： Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    发明人： Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    IPC分类号： A61K49/18 ,  A61K47/48 ,  A61K33/26 ,  A61K33/28 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34

    CPC分类号： A61K49/186 ,  A61K33/24 ,  A61K33/26 ,  A61K33/32 ,  A61K33/34 ,  A61K47/548 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1842 ,  Y10T428/2982

    摘要： The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an α-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.

    摘要翻译： 本申请公开了纳米颗粒，特别是超顺磁性氧化铁的纳米颗粒，其可用于铁疗法和诸如磁共振（MR）的诊断成像。 所公开的纳米颗粒已经用含有聚乙二醇作为亲水部分的α-羟基膦酸缀合物进行处理，以使纳米颗粒充分亲水以发现在诊断成像中的应用。 所公开的改性亲水性纳米粒子是其中改性缀合物的亲水部分是聚环氧乙烷基聚合物并具有大于5,000道尔顿且小于或等于约30,000道尔顿的分子量的那些。 令人惊讶的是，与其中基于PEG的亲水部分具有小于5,000的分子量的类似纳米颗粒相比，这些纳米颗粒在保留的纳米颗粒的肝中具有更快速和完整的加工。

    DRUG DELIVERY WITH STIMULUS RESPONSIVE BIOPOLYMERS
    5.
    发明申请
    DRUG DELIVERY WITH STIMULUS RESPONSIVE BIOPOLYMERS 审中-公开
    药物递送与刺激性反应性生物反应器

    公开(公告)号：US20100189643A1

    公开(公告)日：2010-07-29

    申请号：US12374816

    申请日：2007-07-17

    申请人： Ashutosh Chilkoti ,  Matthew Robert Dreher ,  Daniel Eugene Meyer

    发明人： Ashutosh Chilkoti ,  Matthew Robert Dreher ,  Daniel Eugene Meyer

    IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K51/00

    CPC分类号： A61K51/088 ,  A61K47/64

    摘要： The present invention provides conjugate compounds comprising (a) an active compound; (b) optionally, but in some embodiments preferably, an affinity binding agent; and (c) a block copolymer, the block copolymer comprising: (i) a first elastin-like polypeptide having a first Tt and (U) a second elastin-like polypeptide having a second Tt greater than the first Tt. Method for the targeted delivering of an active compound in vivo to a selected region within a subject with such agents are also described.

    摘要翻译： 本发明提供了包含（a）活性化合物的缀合物化合物; （b）任选地，但在一些实施方案中优选地，亲和力结合剂; 和（c）嵌段共聚物，所述嵌段共聚物包含：（i）具有第一Tt的第一弹性蛋白样多肽和（U）具有大于第一Tt的第二Tt的第二弹性蛋白样多肽。 还描述了用这种试剂将活性化合物在体内靶向递送到受试者内的选定区域的方法。