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公开(公告)号：US08795321B2
公开(公告)日：2014-08-05
申请号：US13221848
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
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公开(公告)号：US08864790B2
公开(公告)日：2014-10-21
申请号：US12297419
申请日：2007-04-16
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
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公开(公告)号：US08795320B2
公开(公告)日：2014-08-05
申请号：US13221843
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
摘要翻译： 血管内植入物递送系统通过将接合植入物的接合构件保持在输送系统的远端处的孔附近的位置来承载植入物。 接合构件通过阻碍接合构件通过孔的运动的绳索保持在孔的近侧。 接合构件在由输送系统限定的区域内自由旋转和移动，允许植入物通过输送系统的移动和植入物通过输送导管对施加到植入物的力作出反应。 一旦植入物处于期望的植入位置，则绳索被移动远离孔，并且接合构件被允许远离输送系统移动。
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公开(公告)号：US08777978B2
公开(公告)日：2014-07-15
申请号：US13221852
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
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公开(公告)号：US20120065720A1
公开(公告)日：2012-03-15
申请号：US13221843
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
IPC分类号： A61F2/84
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
摘要翻译： 血管内植入物递送系统通过将接合植入物的接合构件保持在输送系统的远端处的孔附近的位置来承载植入物。 接合构件通过阻碍接合构件通过孔的运动的绳索保持在孔的近侧。 接合构件在由输送系统限定的区域内自由旋转和移动，允许植入物通过输送系统的移动和植入物通过输送导管对施加到植入物的力作出反应。 一旦植入物处于期望的植入位置，则绳索被移动远离孔，并且接合构件被允许远离输送系统移动。
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公开(公告)号：US20120226305A1
公开(公告)日：2012-09-06
申请号：US13221848
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
IPC分类号： A61F2/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
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公开(公告)号：US20110313447A1
公开(公告)日：2011-12-22
申请号：US13221852
申请日：2011-08-30
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
IPC分类号： A61F2/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
摘要翻译： 血管内植入物递送系统通过将接合植入物的接合构件保持在输送系统的远端处的孔附近的位置来承载植入物。 接合构件通过阻碍接合构件通过孔的运动的绳索保持在孔的近侧。 接合构件在由输送系统限定的区域内自由旋转和移动，允许植入物通过输送系统的移动和植入物通过输送导管对施加到植入物的力作出反应。 一旦植入物处于期望的植入位置，则绳索被移动远离孔，并且接合构件被允许远离输送系统移动。
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公开(公告)号：US20100030200A1
公开(公告)日：2010-02-04
申请号：US12297419
申请日：2007-04-16
申请人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
发明人： Brian Michael Strauss , Earl Howard Slee , Ramon Torres Carrillo , Khoa Dang Vu , William Robert Patterson , Jessica Liang , Richard Stephen Bein , Todd Jeffrey Hewitt , Stacy Leon Faught , Vince Divino , Darrell Christopher Drysen , Mark Philip Ashby , Justin Arthur Klotz , Maria De Jesus Sanson , Scott William Brennan , Lawrason Charles Wilbur , Lester Eugene Oestreich
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12054 , A61B2017/2913 , A61B2017/2924 , A61F2/01 , A61F2/82 , A61F2230/0006
摘要： An intravascular implant delivery system carries an implant by retaining an engagement member engaging the implant in a position proximal of an aperture at a distal end of the delivery system. The engagement member is retained proximal to the aperture by a cord that obstructs the movement of the engagement member through the aperture. The engagement member is free to rotate and move within an area defined by the delivery system, allowing the implant to react to forces imparted to the implant by the movement of the delivery system and implant through a delivery catheter. Once the implant is in a desired implant position, the cord is moved away from an aperture and the engagement member is allowed to move away from the delivery system.
摘要翻译： 血管内植入物递送系统通过将接合植入物的接合构件保持在输送系统的远端处的孔附近的位置来承载植入物。 接合构件通过阻碍接合构件通过孔的运动的绳索保持在孔的近侧。 接合构件在由输送系统限定的区域内自由旋转和移动，允许植入物通过输送系统的移动和植入物通过输送导管对施加到植入物的力作出反应。 一旦植入物处于期望的植入位置，则绳索被移动远离孔，并且接合构件被允许远离输送系统移动。
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公开(公告)号：US08163704B2
公开(公告)日：2012-04-24
申请号：US12906682
申请日：2010-10-18
申请人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
发明人： Gregory Raymond Bebernitz , Mark G. Bock , Dumbala Srinivas Reddy , Atul Kashinath Hajare , Vinod Vyavahare , Sandeep Bhausaheb Bhosale , Suresh Eknath Kurhade , Videsh Salunkhe , Nadim S. Shaikh , Debnath Bhuniya , P. Venkata Palle , Lili Feng , Jessica Liang
CPC分类号： A61K31/7052 , A61K31/7048 , A61K31/706 , C07D405/10 , C07D407/10 , C07D413/10 , C07H7/04
摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.
摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。
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![Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof](/abs-image/US/2008/02/21/US20080045510A1/abs.jpg.150x150.jpg)
10.发明申请Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof 审中-公开6-甲氧基-8- [4-（1-（5-氟） - 喹啉-8-基 - 哌啶-4-基） - 哌嗪-1-基] - 喹啉的琥珀酸盐及其结晶形式公开(公告)号：US20080045510A1
公开(公告)日：2008-02-21
申请号：US11811022
申请日：2007-06-08
申请人： Jessica Liang , Shuimei Wang
发明人： Jessica Liang , Shuimei Wang
IPC分类号： A61K31/496 , A61K31/506 , A61K31/551 , A61K31/5513 , A61P15/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P3/04 , C07D401/14
CPC分类号： A61K31/496 , C07D401/14
摘要： The present invention relates to succinic acid salt forms of the 5-HT1A binding agent 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline, as well as crystalline forms thereof, pharmaceutical compositions thereof, and methods of use thereof.
摘要翻译： 本发明涉及5-HT 1A结合剂6-甲氧基-8- [4-（1-（5-氟） - 喹啉-8-基 - 哌啶-1-基] 吡啶-4-基） - 哌嗪-1-基] - 喹啉及其结晶形式，其药物组合物及其使用方法。
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