公开(公告)号：US08828951B2

公开(公告)日：2014-09-09

申请号：US13614534

申请日：2012-09-13

申请人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

发明人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC分类号： A61K31/70

CPC分类号： A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运体（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。

公开(公告)号：US08466114B2

公开(公告)日：2013-06-18

申请号：US13425888

申请日：2012-03-21

申请人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

发明人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。

公开(公告)号：US08163704B2

公开(公告)日：2012-04-24

申请号：US12906682

申请日：2010-10-18

申请人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

发明人： Gregory Raymond Bebernitz ,  Mark G. Bock ,  Dumbala Srinivas Reddy ,  Atul Kashinath Hajare ,  Vinod Vyavahare ,  Sandeep Bhausaheb Bhosale ,  Suresh Eknath Kurhade ,  Videsh Salunkhe ,  Nadim S. Shaikh ,  Debnath Bhuniya ,  P. Venkata Palle ,  Lili Feng ,  Jessica Liang

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H1/00

CPC分类号： A61K31/7052 ,  A61K31/7048 ,  A61K31/706 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07H7/04

摘要： This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

摘要翻译： 本发明涉及由式（I）表示的化合物：其中变量如上文所定义，其可用于治疗D-葡萄糖共转运蛋白（SGLT）介导的疾病和病症，例如， 糖尿病。 本发明还提供了治疗这些疾病和病症以及组合物等的治疗方法。

公开(公告)号：US20080207536A1

公开(公告)日：2008-08-28

申请号：US11572754

申请日：2005-07-13

申请人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Gobind Singh Kapkoti ,  Anish Bandyopadhyay ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Anjan Chakrabarti ,  Yogesh Baban Surase ,  Mohammad Salman ,  Ashok Rattan

发明人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Gobind Singh Kapkoti ,  Anish Bandyopadhyay ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Anjan Chakrabarti ,  Yogesh Baban Surase ,  Mohammad Salman ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/08

摘要： The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for the treatment or prevention of a condition caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against bacterium such as Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Myobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Baccillus or Enterobactericeae. Processes for the preparation of disclosed compounds, pharmaceutical compositions thereof, and method of treating bacterial infections, are also provided.

摘要翻译： 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起的或由其贡献的病症，特别是针对细菌如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨拉氏菌，衣原体 肉豆蔻，军团菌属，Myobacterium，Helicobacter，Clostridium，拟杆菌属，棒状杆菌属，Baccillus或肠杆菌属。 还提供了制备所公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20090005325A1

公开(公告)日：2009-01-01

申请号：US12094839

申请日：2006-11-21

申请人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

发明人： Biswajit Bas ,  Anjan Chakrabarti ,  Ramadass Venkataramanan ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Rita Katoch ,  Gobind Singh Kapkoti ,  Yogash Baban Surase ,  Mohammad Salman ,  Dilip J. Upadhyay

IPC分类号： A61K31/7048 ,  A61P31/12 ,  C07H17/08

CPC分类号： C07H17/08

摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本文提供了可用作抗菌剂的酮内酯衍生物。 本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌属，衣原体属，支原体 ，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。 还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080318878A1

公开(公告)日：2008-12-25

申请号：US11576033

申请日：2005-09-27

申请人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

发明人： Biswajit Das ,  Rita Katoch ,  Atul Kashinath Hajare ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Sujata Rathy ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  C07H17/08

CPC分类号： C07H17/08

摘要： The present invention provides acylide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, pharmaceutical compositions thereof, and method of treating bacterial infections.

摘要翻译： 本发明提供可用作抗菌剂的酰化物衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属（Chlamydia spp。 ，支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了制备本文公开的化合物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080287376A1

公开(公告)日：2008-11-20

申请号：US11572619

申请日：2005-07-28

申请人： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

发明人： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

IPC分类号： A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC分类号： C07H17/00

摘要： The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp. Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebaclerium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

摘要翻译： 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌。 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。