公开(公告)号：US07879873B2

公开(公告)日：2011-02-01

申请号：US12564129

申请日：2009-09-22

申请人： Brian Nicholas Cook ,  Darren DiSalvo ,  Daniel Robert Fandrick ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Jonathan Timothy Reeves ,  Jinhua J. Song ,  Alan David Swinamer ,  Zhulin Tan

发明人： Brian Nicholas Cook ,  Darren DiSalvo ,  Daniel Robert Fandrick ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Jonathan Timothy Reeves ,  Jinhua J. Song ,  Alan David Swinamer ,  Zhulin Tan

IPC分类号： A61K31/437 ,  C07D515/04

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

公开(公告)号：US08063065B2

公开(公告)日：2011-11-22

申请号：US12969753

申请日：2010-12-16

申请人： Brian Nicholas Cook ,  Darren Di Salvo ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Alan David Swinamer

发明人： Brian Nicholas Cook ,  Darren Di Salvo ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Alan David Swinamer

IPC分类号： A61K31/437 ,  C07D515/04

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了制备方法和使用方法。

公开(公告)号：US20110230521A1

公开(公告)日：2011-09-22

申请号：US12990248

申请日：2009-05-01

申请人： Brian Nicholas Cook ,  Christian Harcken ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  CAN Mao ,  Wang Mao ,  Brain Christopher Raudenbush ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alan David Swinamer

发明人： Brian Nicholas Cook ,  Christian Harcken ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  CAN Mao ,  Wang Mao ,  Brain Christopher Raudenbush ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alan David Swinamer

IPC分类号： A61K31/454 ,  C07D231/14 ,  C07D401/12 ,  C07D401/04 ,  C07D405/14 ,  C07D417/12 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/427 ,  A61P3/10 ,  A61P25/00 ,  A61P29/00 ,  A61P7/00 ,  A61P13/12 ,  A61P25/28 ,  A61P11/06 ,  A61P19/02 ,  A61P17/06 ,  A61P37/08

CPC分类号： C07D401/12 ,  C07D231/14 ,  C07D405/14 ,  C07D417/12

摘要： Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 公开了式（I）的化合物，其阻断CCR1及其配体的相互作用，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫疾病，例如类风湿性关节炎和多发性 硬化。 还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US20110034512A1

公开(公告)日：2011-02-10

申请号：US12937378

申请日：2009-04-23

申请人： Darren Disalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

发明人： Darren Disalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

IPC分类号： A61K31/416 ,  C07D231/56 ,  A61K31/4439 ,  C07D401/02 ,  A61K31/454 ,  A61P1/00 ,  A61P19/02 ,  A61P11/06 ,  A61P13/12 ,  A61P25/28 ,  A61P3/10 ,  A61P37/00

CPC分类号： C07D231/56 ,  C07D401/12

摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US08008327B2

公开(公告)日：2011-08-30

申请号：US12937378

申请日：2009-04-23

申请人： Darren DiSalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

发明人： Darren DiSalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

IPC分类号： A61K31/416 ,  A61K31/4439 ,  C07D231/56 ,  C07D401/02

CPC分类号： C07D231/56 ,  C07D401/12

摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 公开的吲唑化合物可用作CCR1活性的拮抗剂，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫性疾病，例如类风湿性关节炎和多发性硬化症。 还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US08263597B2

公开(公告)日：2012-09-11

申请号：US13184855

申请日：2011-07-18

申请人： Daniel Kuzmich ,  Can Mao ,  Alan David Swinamer ,  David Smith Thomson

发明人： Daniel Kuzmich ,  Can Mao ,  Alan David Swinamer ,  David Smith Thomson

IPC分类号： A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D401/12 ,  C07D413/12 ,  C07D403/12 ,  C07D231/56 ,  A61P17/00 ,  A61P17/06 ,  A61P25/00 ,  A61P3/10 ,  A61P1/00 ,  A61P1/04 ,  A61P37/06 ,  A61P25/28 ,  A61P11/06 ,  A61P13/12 ,  A61P37/00 ,  A61P9/10 ,  A61P19/04

CPC分类号： C07D231/56 ,  C07D401/12

摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 公开的吲唑化合物可用作CCR1活性的拮抗剂，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫性疾病，例如类风湿性关节炎和多发性硬化症。 还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US06525046B1

公开(公告)日：2003-02-25

申请号：US10165372

申请日：2002-06-07

申请人： Pier Francesco Cirillo ,  Roger Dinallo ,  John Robinson Regan ,  Paul S. Riska ,  Alan David Swinamer ,  Zhulin Tan ,  Brian Andrew Walter

发明人： Pier Francesco Cirillo ,  Roger Dinallo ,  John Robinson Regan ,  Paul S. Riska ,  Alan David Swinamer ,  Zhulin Tan ,  Brian Andrew Walter

IPC分类号： A61K315377

CPC分类号： C07D231/38 ,  C07D231/40 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12

摘要： Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

公开(公告)号：US20110118262A1

公开(公告)日：2011-05-19

申请号：US13002658

申请日：2009-06-24

申请人： Joerg Martin Bentzien ,  Stephen James Boyer ,  Jennifer Burke ,  Anne Bettina Eldrup ,  Xin Guo ,  John David Huber ,  Thomas Martin Kirrane ,  Fariba Soleymanzadeh ,  Alan David Swinamer

发明人： Joerg Martin Bentzien ,  Stephen James Boyer ,  Jennifer Burke ,  Anne Bettina Eldrup ,  Xin Guo ,  John David Huber ,  Thomas Martin Kirrane ,  Fariba Soleymanzadeh ,  Alan David Swinamer

IPC分类号： A61K31/5377 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/451 ,  C07D401/10 ,  A61K31/4525 ,  C07D401/06 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/06 ,  A61K31/437 ,  C07D207/08 ,  A61K31/40 ,  A61P9/00

CPC分类号： C07D211/34 ,  C07D207/09 ,  C07D211/82 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D413/10 ,  C07D417/06 ,  C07D471/04

摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.

摘要翻译： 公开了作为钠质子交换体异构体-1（NHE-I）的抑制剂的式（I）化合物和本发明组合物。 还公开了使用和制造它们的方法。

公开(公告)号：US07214802B2

公开(公告)日：2007-05-08

申请号：US11074354

申请日：2005-03-07

申请人： Derek Cogan ,  Ming-Hong Hao ,  Victor Marc Kamhi ,  Craig Andrew Miller ,  Matthew Russell Netherton ,  Alan David Swinamer

发明人： Derek Cogan ,  Ming-Hong Hao ,  Victor Marc Kamhi ,  Craig Andrew Miller ,  Matthew Russell Netherton ,  Alan David Swinamer

IPC分类号： C07D249/06 ,  C07D231/12 ,  C07D401/04 ,  A61K31/4192 ,  A61K31/429 ,  A61K31/4025 ,  A61K31/402

CPC分类号： C07D417/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04

摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

摘要翻译： 公开的抑制细胞因子产生的式（I）化合物，其涉及炎症过程，因此可用于治疗涉及炎症的疾病和病理状态，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US07166628B2

公开(公告)日：2007-01-23

申请号：US10718380

申请日：2003-11-20

申请人： Derek A. Cogan ,  Ming-Hong Hao ,  Kevin Chungeng Qian ,  Alan David Swinamer

发明人： Derek A. Cogan ,  Ming-Hong Hao ,  Kevin Chungeng Qian ,  Alan David Swinamer

IPC分类号： A61K31/41 ,  C07D249/04

CPC分类号： C07D401/12 ,  C07D249/06 ,  C07D403/12

摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，R 3，R 4，R 5， 和R 6'在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。