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公开(公告)号：US07214802B2
公开(公告)日：2007-05-08
申请号：US11074354
申请日：2005-03-07
申请人： Derek Cogan , Ming-Hong Hao , Victor Marc Kamhi , Craig Andrew Miller , Matthew Russell Netherton , Alan David Swinamer
发明人： Derek Cogan , Ming-Hong Hao , Victor Marc Kamhi , Craig Andrew Miller , Matthew Russell Netherton , Alan David Swinamer
IPC分类号： C07D249/06 , C07D231/12 , C07D401/04 , A61K31/4192 , A61K31/429 , A61K31/4025 , A61K31/402
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开的抑制细胞因子产生的式（I）化合物，其涉及炎症过程，因此可用于治疗涉及炎症的疾病和病理状态，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07514458B2
公开(公告)日：2009-04-07
申请号：US11668704
申请日：2007-01-30
申请人： Derek Cogan , Ming-Hong Hao , Victor Marc Kamhi , Craig Andrew Miller , Matthew Russell Netherton , Alan David Swinamer
发明人： Derek Cogan , Ming-Hong Hao , Victor Marc Kamhi , Craig Andrew Miller , Matthew Russell Netherton , Alan David Swinamer
IPC分类号： A61K31/4192 , A61K31/429 , A61K31/4025 , A61K31/402
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开的抑制细胞因子产生的式（I）化合物，其涉及炎症过程，因此可用于治疗涉及炎症的疾病和病理状态，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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3.发明授权Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases 有权苯并呋喃和苯并噻吩化合物可用于治疗细胞因子介导的疾病公开(公告)号：US07550461B2
公开(公告)日：2009-06-23
申请号：US10410688
申请日：2003-04-10
申请人： Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Kevin Chungeng Qian , Gregory Paul Roth , Christopher Ronald Sarko , Alan David Swinamer , Zhaoming Xiong
发明人： Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Kevin Chungeng Qian , Gregory Paul Roth , Christopher Ronald Sarko , Alan David Swinamer , Zhaoming Xiong
IPC分类号： C07D265/28 , C07D295/00 , C07D213/00 , C07D241/00 , C07D241/02 , C07D239/00 , C07D239/02 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D333/50 , C07D409/00 , C07D495/22 , C07D307/77 , C07D307/93
CPC分类号： C07D401/12 , C07C311/08 , C07D209/42 , C07D307/85 , C07D333/70 , C07D403/12 , C07D409/12 , C07D417/12
摘要： Disclosed are amide compounds of formula (I): wherein Ar1, Q, Y and R3-R6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的酰胺化合物：其中式（I）的Ar 1，Q，Y和R 3 -R 6在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07485657B2
公开(公告)日：2009-02-03
申请号：US11120735
申请日：2005-05-03
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D233/90 , C07D231/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07166628B2
公开(公告)日：2007-01-23
申请号：US10718380
申请日：2003-11-20
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D401/12 , C07D249/06 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，R 3，R 4，R 5， 和R 6'在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07569568B2
公开(公告)日：2009-08-04
申请号：US11470849
申请日：2006-09-07
IPC分类号： A61K31/497 , C07D405/00
CPC分类号： C07D401/12 , C07D249/06 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar1，X，R3，R4，R5和R6如本文所定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US06525046B1
公开(公告)日：2003-02-25
申请号：US10165372
申请日：2002-06-07
申请人： Pier Francesco Cirillo , Roger Dinallo , John Robinson Regan , Paul S. Riska , Alan David Swinamer , Zhulin Tan , Brian Andrew Walter
发明人： Pier Francesco Cirillo , Roger Dinallo , John Robinson Regan , Paul S. Riska , Alan David Swinamer , Zhulin Tan , Brian Andrew Walter
IPC分类号： A61K315377
CPC分类号： C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12
摘要： Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
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8.发明申请公开(公告)号：US20110118262A1
公开(公告)日：2011-05-19
申请号：US13002658
申请日：2009-06-24
申请人： Joerg Martin Bentzien , Stephen James Boyer , Jennifer Burke , Anne Bettina Eldrup , Xin Guo , John David Huber , Thomas Martin Kirrane , Fariba Soleymanzadeh , Alan David Swinamer
发明人： Joerg Martin Bentzien , Stephen James Boyer , Jennifer Burke , Anne Bettina Eldrup , Xin Guo , John David Huber , Thomas Martin Kirrane , Fariba Soleymanzadeh , Alan David Swinamer
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4545 , A61K31/451 , C07D401/10 , A61K31/4525 , C07D401/06 , A61K31/506 , A61K31/4709 , C07D413/06 , A61K31/437 , C07D207/08 , A61K31/40 , A61P9/00
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
摘要翻译： 公开了作为钠质子交换体异构体-1（NHE-I）的抑制剂的式（I）化合物和本发明组合物。 还公开了使用和制造它们的方法。
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公开(公告)号：US20110034512A1
公开(公告)日：2011-02-10
申请号：US12937378
申请日：2009-04-23
申请人： Darren Disalvo , Daniel Kuzmich , Can Mao , Hossein Razavi , Christopher Sarko , Alan David Swinamer , David Smith Thomson , Qiang Zhang
发明人： Darren Disalvo , Daniel Kuzmich , Can Mao , Hossein Razavi , Christopher Sarko , Alan David Swinamer , David Smith Thomson , Qiang Zhang
IPC分类号： A61K31/416 , C07D231/56 , A61K31/4439 , C07D401/02 , A61K31/454 , A61P1/00 , A61P19/02 , A61P11/06 , A61P13/12 , A61P25/28 , A61P3/10 , A61P37/00
CPC分类号： C07D231/56 , C07D401/12
摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20090111791A1
公开(公告)日：2009-04-30
申请号：US12281065
申请日：2007-03-08
申请人： Stephane De Lombaert , Anne Bettina Eldrup , Jennifer A. Kowalski , Ingo Andreas Mugge , Fariba Soleymanzadeh , Alan David Swinamer , Steven John Taylor
发明人： Stephane De Lombaert , Anne Bettina Eldrup , Jennifer A. Kowalski , Ingo Andreas Mugge , Fariba Soleymanzadeh , Alan David Swinamer , Steven John Taylor
IPC分类号： A61K31/506 , C07D211/52 , A61K31/445 , A61K31/40 , A61P3/10 , C07D207/16 , C07D403/12
CPC分类号： C07D295/215 , C07D207/12 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
摘要翻译： 公开了对可溶性环氧化物水解酶（sEH）有活性的化合物，其组合物和使用和制备其的方法。
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