公开(公告)号：US20240207249A1

公开(公告)日：2024-06-27

申请号：US18537765

申请日：2023-12-12

Applicant: Brown University

Inventor： John M. SEDIVY ,  Gerwald JOGL ,  Alexandra D'ORDINE

IPC: A61K31/4741 ,  A61K31/136 ,  A61K31/145 ,  A61K31/166 ,  A61K31/167 ,  A61K31/17 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/195 ,  A61K31/196 ,  A61K31/366 ,  A61K31/381 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/433 ,  A61K31/437 ,  A61K31/445 ,  A61K31/4704 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/554 ,  A61P29/00

CPC classification number: A61K31/4741 ,  A61K31/136 ,  A61K31/145 ,  A61K31/166 ,  A61K31/167 ,  A61K31/17 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/195 ,  A61K31/196 ,  A61K31/366 ,  A61K31/381 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/433 ,  A61K31/437 ,  A61K31/445 ,  A61K31/4704 ,  A61K31/50 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/554 ,  A61P29/00

Abstract: Disclosed are methods for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one long interspersed nuclear element 1 (LINE-1, L1) endonuclease inhibitor (L1 EN inhibitor), either alone or in combination with at least one additional therapeutic agent. Effectiveness of the methods can be measured via biomarkers and/or by a decrease in symptoms compared to those symptoms before administration of the L1 EN inhibitor. Specific chemical structures of the L1 EN inhibitors are identified and shown herein.

公开(公告)号：US20230139684A1

公开(公告)日：2023-05-04

申请号：US17778369

申请日：2020-11-23

Applicant: Brown University

Inventor： John M. SEDIVY ,  Gerwald JOGL ,  Alexandra D'ORDINE

IPC: A61K31/4741 ,  A61K31/198 ,  A61K31/366 ,  A61K31/145 ,  A61K31/17 ,  A61K31/4192 ,  A61K31/445 ,  A61K31/166 ,  A61K31/167 ,  A61K31/64 ,  A61K31/4035 ,  A61K31/505 ,  A61K31/423 ,  A61K31/381 ,  A61K31/53 ,  A61K31/635

Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one LINE 1 (L-1) endonuclease inhibitor.

公开(公告)号：US20240197745A1

公开(公告)日：2024-06-20

申请号：US18470182

申请日：2023-09-19

Applicant: BROWN UNIVERSITY

Inventor： John M. SEDIVY ,  Marco DE CECCO

IPC: A61K31/52 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/52 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00

Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).

公开(公告)号：US20210106586A1

公开(公告)日：2021-04-15

申请号：US16934826

申请日：2020-07-21

Applicant: Brown University

Inventor： John M. SEDIVY ,  Marco DE CECCO

IPC: A61K31/52 ,  A61K31/513 ,  A61K45/06 ,  A61P35/00

Abstract: Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).