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公开(公告)号：US06214865B1
公开(公告)日：2001-04-10
申请号：US09334488
申请日：1999-06-16
申请人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
发明人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
IPC分类号： A61K31335
CPC分类号： C07D493/22
摘要： The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the cell to the agents.
摘要翻译： 本发明提供了具有药学活性的软骨素类似物，例如抗癌或抗有丝分裂（有丝分裂阻断）活性，以及鉴定在细胞瞬时暴露于药剂后在细胞中诱导持续有丝分裂阻滞的药剂的方法。
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公开(公告)号：US20110172446A1
公开(公告)日：2011-07-14
申请号：US12855412
申请日：2010-08-12
IPC分类号： C07D493/22
CPC分类号： C07D493/22
摘要： The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
摘要翻译： 本发明提供了用于治疗与过度细胞增殖相关的疾病如癌症的方法和组合物，以及用于合成这些组合物的中间体。
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公开(公告)号：US06365759B1
公开(公告)日：2002-04-02
申请号：US09677485
申请日：2000-10-02
申请人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
发明人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
IPC分类号： C07D40700
CPC分类号： C07D493/22
摘要： Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.
摘要翻译： 用于制备大环类似物的式的中间体化合物
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公开(公告)号：US08097648B2
公开(公告)日：2012-01-17
申请号：US11282505
申请日：2005-11-18
IPC分类号： A61K31/335
CPC分类号： A61K31/4745 , A61K31/335 , A61K31/35 , A61K31/7072 , A61K39/39558 , A61K45/06 , C07D493/22 , A61K2300/00
摘要： The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.
摘要翻译： 本发明提供了用于治疗与过度细胞增殖相关的疾病如癌症的方法和组合物。
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公开(公告)号：US06469182B1
公开(公告)日：2002-10-22
申请号：US09843617
申请日：2001-04-26
申请人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
发明人： Bruce A. Littlefield , Monica H. Palme , Boris M. Seletsky , Murray J. Towle , Melvin J. Yu , Wanjun Zheng
IPC分类号： C07F702
CPC分类号： C07D493/22
摘要： Novel intermediates of the formula They are used in the preparation of macrocyclic analogs.
摘要翻译： 式中的新型中间体它们用于制备大环类似物
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公开(公告)号：US08148554B2
公开(公告)日：2012-04-03
申请号：US12855412
申请日：2010-08-12
申请人： Boris M. Seletsky , Melvin J. Yu , Wanjun Zheng
发明人： Boris M. Seletsky , Melvin J. Yu , Wanjun Zheng
IPC分类号： C07D407/00 , C07D323/00
CPC分类号： C07D493/22
摘要： The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
摘要翻译： 本发明提供了用于治疗与过度细胞增殖相关的疾病如癌症的方法和组合物，以及用于合成这些组合物的中间体。
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7.发明授权3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof 失效（3H）喹唑啉酮CCK拮抗剂及其药物制剂
公开(公告)号：US5075313A
公开(公告)日：1991-12-24
申请号：US581943
申请日：1990-09-13
IPC分类号： A61K31/505 , A61P1/00 , A61P3/04 , A61P25/00 , C07D209/14 , C07D239/91 , C07D403/06
CPC分类号： C07D403/06
摘要： Novel substituted quinazolinones have been found to exhibit specific binding to cholecystokinin (CCK) receptors in the brain and/or peripheral site such as the pancreas and ileum. The quinazolinones are CCK receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders and central nervous system disorders, and are useful for appetite regulation in mammals. Pharmaceutical formulations for such indications are described.
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8.发明授权3-aryl-4(3H) quinazolinone CCK antagonists and pharmaceutical formulations thereof 失效（3H）喹唑啉酮CCK拮抗剂及其药物制剂
公开(公告)号：US5196427A
公开(公告)日：1993-03-23
申请号：US763104
申请日：1991-09-20
IPC分类号： C07D403/06
CPC分类号： C07D403/06
摘要： Novel substituted quinazolinones have been found to exhibit specific binding to cholecystokinin (CCK) receptors in the brain and/or peripheral site such as the pancreas and ileum. The quinazolinones are CCK receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders and central nervous system disorders, and are useful for appetite regulation in mammals. Pharmaceutical formulations for such indications are described.
摘要翻译： 已经发现新的取代喹唑啉酮显示与脑和/或外周部位如胰腺和回肠中的缩胆囊素（CCK）受体的特异性结合。 喹唑啉酮是CCK受体拮抗剂，可用于治疗胃肠道疾病和中枢神经系统疾病，适用于哺乳动物的食欲调节。 描述了用于这种适应症的药物制剂。
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