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公开(公告)号:US20090226472A1
公开(公告)日:2009-09-10
申请号:US11986376
申请日:2007-11-20
申请人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
发明人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
IPC分类号: A61K39/00 , C12N15/11 , C12N15/00 , C12P21/00 , C12N5/06 , A61K38/16 , C07K14/00 , C07K16/18 , G01N33/566
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7155 , G01N33/6869 , Y10S514/826 , Y10S514/885 , Y10S514/886
摘要: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
摘要翻译: 公开了哺乳动物白细胞介素-4受体蛋白,编码哺乳动物IL-4受体的DNA和表达载体,以及作为细胞培养产物的哺乳动物IL-4受体的制备方法。 通过施用有效量的可溶性IL-4受体(sIL-4R)和合适的稀释剂或载体,抑制哺乳动物(包括人)中IL-4依赖性免疫或炎性反应的方法。
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公开(公告)号:US06716587B2
公开(公告)日:2004-04-06
申请号:US10104590
申请日:2002-03-22
申请人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
发明人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
IPC分类号: C01N3353
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7155 , G01N33/6869 , Y10S514/826 , Y10S514/885 , Y10S514/886
摘要: Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammatory response in a mammal, including a human, by administering an effective amount of soluble IL-4 receptor (sIL-4R) and a suitable diluent or carrier.
摘要翻译: 公开了哺乳动物白细胞介素-4受体蛋白,编码哺乳动物IL-4受体的DNA和表达载体,以及作为细胞培养产物的哺乳动物IL-4受体的制备方法。 通过施用有效量的可溶性IL-4受体(sIL-4R)和合适的稀释剂或载体,抑制哺乳动物(包括人)中IL-4依赖性免疫或炎性反应的方法。
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公开(公告)号:US07317090B2
公开(公告)日:2008-01-08
申请号:US10688495
申请日:2003-10-17
申请人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
发明人: Bruce A. Mosley , David J. Cosman , Linda S. Park , M. Patricia Beckmann , Carl J. March , Rejean Idzerda
CPC分类号: C07K16/2866 , A61K38/00 , C07K14/7155 , G01N33/6869 , Y10S514/826 , Y10S514/885 , Y10S514/886
摘要: Methods and comnositions related to antibodies that bind to mammalian Tnterleulcin-4 recentor proteins are disclosed.
摘要翻译: 公开了与结合哺乳动物插入蛋白-4的新蛋白的抗体相关的方法和组合物。
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公开(公告)号:US5350683A
公开(公告)日:1994-09-27
申请号:US091519
申请日:1993-07-12
IPC分类号: A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , C07K13/00
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译: 公开了II型IL-1受体(II型IL-1R)蛋白,编码II型IL-1R的DNA和表达载体,以及作为重组细胞培养产物的产生II型IL-1R的方法。
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公开(公告)号:US06521740B1
公开(公告)日:2003-02-18
申请号:US08441893
申请日:1995-05-16
IPC分类号: C07K14705
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译: 公开了II型IL-1受体(II型IL-1R)蛋白,编码II型IL-1R的DNA和表达载体,以及作为重组细胞培养产物的产生II型IL-1R的方法。
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公开(公告)号:US06504023B1
公开(公告)日:2003-01-07
申请号:US09461908
申请日:1999-12-13
IPC分类号: C12N1506
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
摘要翻译: 公开了II型IL-1受体(II型IL-1R)蛋白,编码II型IL-1R的DNA和表达载体,以及作为重组细胞培养产物的产生II型IL-1R的方法。
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公开(公告)号:US5464937A
公开(公告)日:1995-11-07
申请号:US242211
申请日:1994-05-13
IPC分类号: A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , C07K14/705
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed.
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公开(公告)号:US5767064A
公开(公告)日:1998-06-16
申请号:US442043
申请日:1995-05-16
IPC分类号: A61K38/00 , C07K14/715 , C12N15/06 , C12N15/12 , A01N37/18
CPC分类号: C07K14/7155 , A61K38/00
摘要: Type II IL-1 receptor (type II IL-1R) proteins, DNAs and expression vectors encoding type II IL-1R, and processes for producing type II IL-1R as products of recombinant cell culture, are disclosed. Also disclosed are compositions and methods for regulating an IL-1 mediated immune or inflammatory response in a mammal.
摘要翻译: 公开了II型IL-1受体(II型IL-1R)蛋白,编码II型IL-1R的DNA和表达载体,以及作为重组细胞培养产物的产生II型IL-1R的方法。 还公开了用于调节哺乳动物中IL-1介导的免疫或炎症反应的组合物和方法。
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公开(公告)号:US20080200389A1
公开(公告)日:2008-08-21
申请号:US12082014
申请日:2008-04-07
CPC分类号: C07K14/705
摘要: This invention relates to RIPPA, a new member of the human Na+/H+ antiporter polypeptide family, methods of making such polypeptides, and to methods of using RIPPA and RIPPA-Like polypeptides and agonists or antagonists.
摘要翻译: 本发明涉及RIPPA,人类Na + / H +逆转录多肽家族的新成员,制备此类多肽的方法,以及使用RIPPA和RIPPA-样多肽和激动剂或拮抗剂的方法。
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