Hybrid genes for expression of stimulatory factors in activated T cells
    8.
    发明授权
    Hybrid genes for expression of stimulatory factors in activated T cells 失效
    用于在活化的T细胞中表达刺激因子的杂交基因

    公开(公告)号:US06593124B1

    公开(公告)日:2003-07-15

    申请号:US09213993

    申请日:1998-12-16

    IPC分类号: C12N121

    摘要: Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T helper cells. The vectors are comprised of a region encoding a stimulatory factor polypeptide operably linked to a heterologous transcriptional control region. Expression of the stimulatory factor polypeptide from the recombinant polynucleotide in an activated lymphocyte renders the proliferative response of less dependent on lymphocyte T helper cells. When the lymphocyte is activated by binding of its cognate antigen the transcriptional control region causes transcription of the stimulatory factor encoding region. The cells containing the vector, particularly CTLs, are of use in immunotherapy.

    摘要翻译: 提供重组载体,其使活化的淋巴细胞,特别是细胞毒性T淋巴细胞的增殖反应减少对T辅助细胞的依赖性。 载体由编码可操作地连接到异源转录控制区的刺激因子多肽的区域组成。 来自重组多核苷酸的刺激因子多肽在活化淋巴细胞中的表达使得对淋巴细胞T辅助细胞较少依赖的增殖反应。 当淋巴细胞通过其同源抗原的结合而被激活时,转录控制区引起刺激因子编码区的转录。 含有载体,特别是CTL的细胞可用于免疫治疗。