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公开(公告)号：US20050231682A1
公开(公告)日：2005-10-20
申请号：US11146153
申请日：2005-06-07
申请人： Bruce DeWoolfson , Dale DeVore
发明人： Bruce DeWoolfson , Dale DeVore
CPC分类号： A61K38/1709 , A61K38/39 , G02C7/047
摘要： Two types of compositions having an eye-drop delivery system are used during or after an orthokeratology procedure to prevent or retard relaxation of corneal tissue back to the original anterior curvature of the cornea. Each composition functions independently from the others and is a different approach of preparing a stabilizing agent. The first composition is directed to a biologically compatible composition comprising fibril associated collagens with interrupted triple helices (FACITs) and/or small leucine-rich repeat proteoglycans (SLRPs). The fibril associated collagen family includes various types of collagens, such as type VI, type XX, type XII, and type XIV. The small leucine-rich repeat proteoglycans family includes decorin, keratocan, biglycan, epiphycan, lumican, mimecan, and fibromodulin. The second composition includes the enzyme found as a normal component of tissues, plasma, or epidermis, such as transglutaminase.
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公开(公告)号：US20160000885A1
公开(公告)日：2016-01-07
申请号：US14807117
申请日：2015-07-23
申请人： Vance Thompson , Bruce DeWoolfson , Dale DeVore
发明人： Vance Thompson , Bruce DeWoolfson , Dale DeVore
CPC分类号： A61K38/39 , A61K9/0048 , A61K38/1709 , A61K38/45 , C07K14/4725
摘要： Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.
摘要翻译： 公开了在角膜中稳定胶原原纤维的方法。 可以通过用交联胶原原纤维的蛋白质（例如核心蛋白聚糖）处理角膜来实现稳定化。 稳定方法包括在外科手术之前，期间或之后治疗角膜，治疗角膜炎，以及治疗圆锥角膜。
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公开(公告)号：US20110060267A1
公开(公告)日：2011-03-10
申请号：US12922424
申请日：2009-03-10
申请人： Bruce DeWoolfson , Dale DeVore
发明人： Bruce DeWoolfson , Dale DeVore
IPC分类号： A61F9/00
摘要： Methods of strengthening the biomechanical properties of the cornea by exposing the cornea to ultraviolet light in the presence of a photoinitiator are described. These methods can be used to treat keratoconus. They can also be used to treat ectasia following a surgical procedure, or to strengthen the cornea prior to a surgical procedure.
摘要翻译： 描述了通过在光引发剂的存在下将角膜暴露于紫外光来增强角膜的生物力学性质的方法。 这些方法可用于治疗圆锥角膜。 它们也可用于治疗外科手术后的扩张，或在外科手术之前加强角膜。
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公开(公告)号：US20090105127A1
公开(公告)日：2009-04-23
申请号：US12285683
申请日：2008-10-10
申请人： Vance Thompson , Bruce DeWoolfson , Dale DeVore
发明人： Vance Thompson , Bruce DeWoolfson , Dale DeVore
IPC分类号： A61K38/16
CPC分类号： A61K38/39 , A61K9/0048 , A61K38/1709 , A61K38/45 , C07K14/4725
摘要： Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.
摘要翻译： 公开了在角膜中稳定胶原原纤维的方法。 可以通过用交联胶原原纤维的蛋白质（例如核心蛋白聚糖）处理角膜来实现稳定化。 稳定方法包括在外科手术之前，期间或之后治疗角膜，治疗角膜炎，以及治疗圆锥角膜。
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