公开(公告)号：US6167313A

公开(公告)日：2000-12-26

申请号：US180399

申请日：1998-11-09

申请人： Bruce Nathaniel Gray ,  Stephen Keith Jones

发明人： Bruce Nathaniel Gray ,  Stephen Keith Jones

IPC分类号： A61N2/04 ,  A61K9/50 ,  A61K33/26 ,  A61K41/00 ,  A61N1/40 ,  A61N2/00 ,  A61N2/10 ,  A61F2/00

CPC分类号： A61K9/5094 ,  A61K41/0052 ,  A61N1/406

摘要： A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5.times.10.sup.-8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5.times.10.sup.7 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5.times.10.sup.7 A/s to generate hysteresis heat in the diseased tissue.

摘要翻译： PCT No.PCT / AU97 / 00287 Sec。 371日期：1998年11月9日 102（e）1998年11月9日PCT PCT 1997年5月9日PCT公布。 出版物WO97 / 43005 日期1997年11月20日一种用于患者的病变组织的特异性处理方法，包括以下步骤：（i）至少选择具有至少约4.5×10-8 Jm / Ag的磁加热效率的磁性材料， 当磁场条件等于或小于约7.5×107A / s时; （ii）将磁性材料输送到病人的病变组织; 和（iii）将患者中的磁性材料暴露于具有大于约10kHz的频率的线性交变磁场和场强度，使得场强，频率和暴露区域的半径的乘积小于约 7.5×10 7 A / s以在病变组织中产生滞后热。

公开(公告)号：US06565887B1

公开(公告)日：2003-05-20

申请号：US09569788

申请日：2000-05-12

申请人： Bruce Nathaniel Gray ,  Stephen Keith Jones

发明人： Bruce Nathaniel Gray ,  Stephen Keith Jones

IPC分类号： A61K914

CPC分类号： A61K9/5094 ,  A61K41/0052 ,  A61N1/406

摘要： A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5×10−8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5×107 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5×107 A/s to generate hysteresis heat in the diseased tissue.

摘要翻译： 一种用于对患者的患病组织进行位置特异性治疗的方法，包括以下步骤：（i）至少选择磁性材料，所述磁性材料的磁加热效率为至少约4.5×10-8 Jm / Ag，当磁场条件为 等于或小于约7.5×10 7 A / s; （ii）将磁性材料输送到病人的病变组织; 和（iii）将患者中的磁性材料暴露于具有大于约10kHz的频率的线性交变磁场和场强度，使得场强，频率和暴露区域的半径的乘积小于约 7.5×10 7 A / s以在病变组织中产生滞后热。

公开(公告)号：US06537518B1

公开(公告)日：2003-03-25

申请号：US09639566

申请日：2000-08-16

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

IPC分类号： A61K5100

CPC分类号： B01J13/04 ,  A61K51/1251 ,  A61K51/1258

摘要： A particulate material comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns, the microspheres being formed from a base material comprising greater than 70% by weight of yttria or another yttrium-containing compound together with one or more compounds selected from the group consisting of alumina or another aluminium-containing compound, zirconia or another zirconium-containing compound, and silica or another silicon-containing compound. The particulate material may comprise a beta-radiation emitting radionuclide ytrrium-90, and be used in selective internal radiation therapy (SIRT) of various forms of cancer and tumors.

摘要翻译： 颗粒材料包括直径在5至200微米范围内的中空或杯形陶瓷微球，所述微球由包含大于70重量％的氧化钇或另一个含钇化合物的基材形成，以及一个 或更多选自氧化铝或另一种含铝化合物，氧化锆或其它含锆化合物的化合物，以及二氧化硅或其它含硅化合物。颗粒材料可以包含β-辐射发射放射性核素ytrrium-90，和 用于各种形式的癌症和肿瘤的选择性内部放射治疗（SIRT）。

公开(公告)号：US6120439A

公开(公告)日：2000-09-19

申请号：US326110

申请日：1999-06-04

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

摘要： A clamping device (10) for clampingly interconnecting a first elongate element (17) and a second elongate element (15). The clamping device (10) comprises a shaft (19), and a first clamping member (21) mounted on the shaft. The first clamping member (21) has first and second clamping sections (31, 32) between which the first elongate element (17) can be slidingly received and clampingly engaged. An aperture (73) is provided in the shaft (19) adjacent the second section (32) of the first clamping member (21) to slidingly receive the second elongate member (15). A second clamping member (22) is mounted on the shaft (19) and is displaceable therealong for clamping the second elongate element (15) between the first clamping member (21) and the second clamping member (22). A cam locking mechanism (23) is operably connected to the shaft (19) for selectively moving the clamping device between clamping and non-clamping conditions. In moving the clamping device (10) into the clamping condition, the cam locking mechanism (23) causes displacement of the second clamping member (22) along the shaft (19) such that the second elongate element (15) is clampingly engaged between the first clamping member (21) and the second clamping member (22).

公开(公告)号：USD498845S1

公开(公告)日：2004-11-23

申请号：US29183539

申请日：2003-06-12

申请人： Bruce Nathaniel Gray

设计人： Bruce Nathaniel Gray

公开(公告)号：US06258338B1

公开(公告)日：2001-07-10

申请号：US09178259

申请日：1998-10-23

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

IPC分类号： A61K5100

CPC分类号： A61K51/1241 ,  A61K51/1258 ,  B01J13/04

摘要： A particulate material which comprises hollow or cup-shaped ceramic microspheres having a diameter in the range of from 5 to 200 microns. The material may comprise a beta- or gamma-emitting radionuclide and be used in selective internal radiation therapy (SIRT) of various forms of cancer and tumours.

摘要翻译： 一种颗粒材料，其包括直径在5至200微米范围内的中空或杯形陶瓷微球。 该材料可以包含β-或γ-发射放射性核素，并且可用于各种形式的癌症和肿瘤的选择性内部放射治疗（SIRT）。

公开(公告)号：US5954639A

公开(公告)日：1999-09-21

申请号：US194328

申请日：1998-11-24

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

IPC分类号： A61B17/02

CPC分类号： A61B17/0293 ,  A61B17/02

摘要： The present invention provides a retractor assembly capable of supporting at least a tissue engaging member in a manner allowing self alignment of the member subject to the pull force of the tissue engaged by the member. The retractor assembly comprises: (i) a frame member which supports a support member; (ii) at least one tissue engaging member which possesses at least a mounting arrangement which is capable of releasably engaging the support member; and (iii) a locking member which is capable of releasably engaging the tissue engaging member with the frame member and the support member to hold the tissue engaging member(s) in a substantially immovable position.

摘要翻译： PCT No.PCT / AU97 / 00335 Sec。 371日期：1998年11月24日 102（e）1998年11月24日PCT PCT 1997年5月27日PCT公布。 出版物WO97 / 45059 日期1997年12月4日本发明提供了一种牵开器组件，其能够以允许构件自身对准的方式支撑至少组织接合构件，所述构件受到由构件接合的组织的拉力的作用。 牵开器组件包括：（i）支撑支撑构件的框架构件; （ii）至少一个组织接合构件，其至少具有能够可释放地接合支撑构件的安装装置; 以及（iii）锁定构件，其能够将组织接合构件与框架构件和支撑构件可释放地接合以将组织接合构件保持在基本上不可移动的位置。

公开(公告)号：US20100215571A1

公开(公告)日：2010-08-26

申请号：US12712843

申请日：2010-02-25

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

IPC分类号： A61K51/06 ,  A61P35/00

CPC分类号： A61K51/1251 ,  A61K51/06 ,  A61K51/1255

摘要： The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix and stably incorporated radionuclide, processes for its production and a method of radiation therapy utilising the particulate material.

摘要翻译： 本发明涉及直径在5至200微米范围内的颗粒材料，其包含聚合物基质并稳定地并入放射性核素，其生产方法和使用该颗粒材料的放射治疗方法。

公开(公告)号：US06998105B2

公开(公告)日：2006-02-14

申请号：US10173497

申请日：2002-06-17

申请人： Andrew John Ruys ,  Bruce Nathaniel Gray

发明人： Andrew John Ruys ,  Bruce Nathaniel Gray

IPC分类号： A61K51/00

CPC分类号： C03C3/091 ,  A61K51/1255

摘要： The invention relates to a particulate material consisting of a low density radiation-tolerant glass and a radionuclide incorporated into the low density glass or coated on the low density glass, the glass having a density of less than 2.5 g/cm3, processes for its production and a method of radiation therapy utilising the patentable material.

摘要翻译： 本发明涉及由低密度辐射耐受性玻璃和掺入低密度玻璃中的或放在低密度玻璃上的放射性核素组成的颗粒材料，该玻璃的密度小于2.5g / cm 3， / SUP>，其生产过程和使用可专利材料的放射治疗方法。

公开(公告)号：US06234961B1

公开(公告)日：2001-05-22

申请号：US09292512

申请日：1999-04-15

申请人： Bruce Nathaniel Gray

发明人： Bruce Nathaniel Gray

IPC分类号： A61B132

CPC分类号： A61B17/0293 ,  A61B17/02 ,  A61B2017/2933 ,  Y10T403/32631

摘要： A ball and socket interconnection capable of use in surgical retractor systems comprising a ball member and a socket member, the socket member defining an entry and being adapted to releasably receive the ball member such that when the ball member is received in the socket member it is capable of pivotal and rotational movement within the socket, the ball member having two spherical end surfaces between which is located an intermediate section, the spherical end surfaces having a radius of curvature greater than the radius of curvature of the entry and the intermediate section having a radius of curvature less than the radius of curvature of the entry, whereby the intermediate section renders the ball member releasably receivable in the socket member.

摘要翻译： 一种能够用于包括球形部件和插座部件的外科牵开器系统中的球窝式连接器，所述插座构件限定入口并且适于可释放地容纳所述球形构件，使得当所述球构件被容纳在所述插座构件中时， 能够在所述插座内枢转和旋转运动，所述球部件具有两个球形端面，所述球形端面之间位于中间部分，所述球形端面的曲率半径大于所述入口的曲率半径，所述中间部分具有 曲率半径小于入口的曲率半径，由此中间部分使球部件可释放地容纳在插座构件中。