-
公开(公告)号：US06448285B1
公开(公告)日：2002-09-10
申请号：US09297636
申请日：1999-07-26
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地用于治疗雄激素依赖性疾病如脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸系的新化合物和含有它们的组合物。
-
公开(公告)号：US06596753B2
公开(公告)日：2003-07-22
申请号：US10176674
申请日：2002-06-24
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as, for example, seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions-containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地旨在治疗雄激素依赖性疾病，例如，脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸家族的新化合物和含有它们的组合物。
-
3.发明授权Antioxidative dermocosmetic compositions comprising very low dosages of melatonin/analogs 失效包含非常低剂量的褪黑激素/类似物的抗氧化皮肤化妆品组合物
公开(公告)号：US5985293A
公开(公告)日：1999-11-16
申请号：US900109
申请日：1997-07-25
申请人： Pierre Tachon , Francis Pruche , Catherine Gerst , Jean-Fran.cedilla.ois Nadaud , Lionel Breton
发明人： Pierre Tachon , Francis Pruche , Catherine Gerst , Jean-Fran.cedilla.ois Nadaud , Lionel Breton
IPC分类号： A61K8/49 , A61K8/00 , A61K8/04 , A61K31/40 , A61Q7/00 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/40
摘要： Topically applicable dermocosmetic compositions for improving or maintaining the appearance of human skin or the scalp, comprise a minor antioxidant effective amount of melatonin or analog thereof, formulated into a topically applicable, cosmetically/dermatologically acceptable vehicle, diluent or carrier therefor, such minor antioxidant effective amount being less than 10.sup.-4 % by weight relative to the total weight thereof, e.g., no greater than 0.5.times.10.sup.-4 % or ranging from 10.sup.-12 % to 10.sup.-15 % by weight thereof.
摘要翻译： 用于改善或保持人类皮肤或头皮外观的局部适用皮肤外用剂组合物包含配制成局部适用的美容/皮肤病学可接受的媒介物，稀释剂或载体的少量抗氧化剂有效量的褪黑激素或其类似物， 的量相对于其总重量小于10-4重量％，例如不大于0.5×10 -4％或10-12重量％至10-15重量％。
-
4.发明授权6-substituted pyrimidine 3-oxides for promoting pigmentation of the skin/hair 失效6-取代的嘧啶3-氧化物，用于促进皮肤/头发的色素沉着公开(公告)号：US06380263B1
公开(公告)日：2002-04-30
申请号：US08931890
申请日：1997-09-17
申请人： Francis Pruche , Catherine Gerst
发明人： Francis Pruche , Catherine Gerst
IPC分类号： A61P1731
CPC分类号： A61Q19/04 , A61K8/4953 , A61K31/506 , A61K31/513 , A61Q5/065
摘要： Pigmentation of human skin and/or hair is promoted by administering to individuals in need of such treatment, advantageously topically, an effective tyrosinase activity-stimulating amount of at least one 6-substituted pyrimidine 3-oxide having the structural formula (I): in which R1 and R2, which may be identical or different, are each a hydrogen atom or a C1-C12 alkyl radical; and R3 and R4, which may be identical or different, are each a C1-C12 alkyl radical or, when taken together, form a heterocycle with the nitrogen atom from which they depend, with the proviso that, when R3 and R4, taken together, form a piperidino ring, then at least one of the radicals R1 or R2 must be other than a hydrogen atom.
摘要翻译： 通过给予需要这种治疗的个体，有利地局部地有效的具有酪氨酸酶活性的至少一种具有结构式（I）的6-取代嘧啶3-氧化物的有效的酪氨酸酶活性刺激量来促进人皮肤和/或头发的着色： 其中R1和R2可以相同或不同，分别为氢原子或C1-C12烷基; 和可以相同或不同的R 3和R 4各自为C 1 -C 12烷基，或者当它们一起形成与它们相关的氮原子的杂环时，条件是当R 3和R 4一起时 形成哌啶子基环，则基团R 1或R 2中的至少一个必须不是氢原子。
-
-
-
搜索结果
4 条记录 (耗时 0.023 秒)
