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公开(公告)号：US06448285B1
公开(公告)日：2002-09-10
申请号：US09297636
申请日：1999-07-26
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地用于治疗雄激素依赖性疾病如脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸系的新化合物和含有它们的组合物。
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公开(公告)号：US06596753B2
公开(公告)日：2003-07-22
申请号：US10176674
申请日：2002-06-24
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as, for example, seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions-containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地旨在治疗雄激素依赖性疾病，例如，脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸家族的新化合物和含有它们的组合物。
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3.发明授权公开(公告)号：US06335359B1
公开(公告)日：2002-01-01
申请号：US09617039
申请日：2000-07-14
申请人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
发明人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
IPC分类号： A01N4338
CPC分类号： A61K8/492 , A61Q19/00 , A61Q19/008
摘要： Indolecarboxylic acid compounds and derivatives thereof are useful for treating seboarhea and the dermatitides associated therewith, especially acne and/or blackheads and/or comedones.
摘要翻译： 吲哚羧酸化合物及其衍生物可用于治疗与其相关的皮脂腺炎和皮肤病，特别是痤疮和/或黑头粉刺和/或粉刺。
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公开(公告)号：US06548532B2
公开(公告)日：2003-04-15
申请号：US10000293
申请日：2001-12-04
申请人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
发明人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
IPC分类号： A61K31405
CPC分类号： A61K8/492 , A61Q19/00 , A61Q19/008
摘要： Indolecarboxylic acid compounds and derivatives thereof are useful for treating seboarhea and the dermatitides associated therewith, especially acne and/or blackheads and/or comedones.
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5.发明授权Indolecarboxylic compounds for inducing/stimulating hair growth and/or retarding hair loss 失效用于诱导/刺激头发生长和/或减缓脱发的吲哚类化合物公开(公告)号：US06541507B1
公开(公告)日：2003-04-01
申请号：US09617106
申请日：2000-07-14
申请人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
发明人： Maria Dalko , Jean-Baptiste Galey , Bruno Bernard
IPC分类号： A61K3140
摘要： Indolecarboxylic acid compounds and derivatives thereof, notably 4,6-dimethoxyindole-2-carboxylic acid and derivatives thereof, are especially useful for inducing/stimulating mammalian hair growth and/or preventing/retarding mammalian hair loss.
摘要翻译： 吲哚羧酸化合物及其衍生物，特别是4,6-二甲氧基吲哚-2-羧酸及其衍生物，特别可用于诱导/刺激哺乳动物毛发生长和/或预防/延缓哺乳动物脱发。
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6.发明授权Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss 有权用于诱导/刺激毛发生长和/或减缓脱发的嘧啶3-氧化物化合物公开(公告)号：US06291468B1
公开(公告)日：2001-09-18
申请号：US09360495
申请日：1999-07-23
IPC分类号： A61K706
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical —OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
摘要翻译： 含有头发生长/脱毛的美容/治疗组合物含有有效量的至少一种具有结构式（I）的2-氨基-4-烷基氨基嘧啶3-氧化物：其中R1是具有5至20个 碳原子，Z为氢原子或基团-OR2，其中R2为碳原子数为1〜12的烷基，或其酰基衍生物或其酸加成盐。
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7.发明授权公开(公告)号：US06653317B2
公开(公告)日：2003-11-25
申请号：US10301733
申请日：2002-11-22
IPC分类号： C07D23948
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical −OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
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8.发明授权Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss 有权用于诱导/刺激毛发生长和/或减缓脱发的嘧啶3-氧化物化合物公开(公告)号：US06511659B2
公开(公告)日：2003-01-28
申请号：US09874053
申请日：2001-06-06
IPC分类号： C07D23948
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical —OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
摘要翻译： 含有头发生长/脱毛的美容/治疗组合物含有有效量的至少一种具有结构式（I）的2-氨基-4-烷基氨基嘧啶3-氧化物：其中R1是具有5至20个 碳原子，Z为氢原子或基团-OR2，其中R2为碳原子数1〜12的烷基，或其酰基衍生物或其酸加成盐。
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公开(公告)号：US5968487A
公开(公告)日：1999-10-19
申请号：US897058
申请日：1997-07-18
IPC分类号： A61K8/00 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/49 , A61K8/92 , A61K31/425 , A61P17/00 , A61Q19/00 , A61Q19/02 , C07D417/12 , A61K7/48
CPC分类号： C07D417/12 , A61K8/49 , A61Q19/02 , Y10S424/05 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： The invention relates to a novel derivative of kojic acid of formula (I) and to its use, in a composition for topical application as a depigmenting and/or bleaching agent for skin: ##STR1## The invention also relates to a process for depigmenting and/or bleaching skin, which includes applying to the skin a composition that contains 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl 2-oxothiazolidine-4-carboxylate of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（I）的曲酸的新型衍生物及其在局部用作皮肤脱色和/或漂白剂的组合物中的用途：本发明还涉及脱色和/或漂白的方法 皮肤，其包括向皮肤施用包含式（I）的5-羟基-4-氧代-4H-吡喃-2-基甲基2-氧代噻唑烷-4-羧酸酯或其药学上可接受的盐的组合物。
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10.发明授权Salicylic acid derivatives and their use in cosmetic or dermatological compositions 失效水杨酸衍生物及其在化妆品或皮肤病学组合物中的用途公开(公告)号：US06255297B1
公开(公告)日：2001-07-03
申请号：US09367307
申请日：1999-10-26
申请人： Maria Dalko , Jean-Baptiste Galey
发明人： Maria Dalko , Jean-Baptiste Galey
IPC分类号： A61K3160
CPC分类号： A61K8/37 , A61Q19/00 , A61Q19/08 , C07H15/203
摘要： The invention relates to novel salicylic acid derivatives and to the use thereof in a cosmetic and/or dermatological composition intended for skincare, in particular to combat the signs of ageing of the skin and/or to improve the radiance of the complexion and/or to smooth out facial and/or body skin and/or to treat wrinkles and fine lines on the skin and/or to stimulate the process of epidermal renewal.
摘要翻译： 本发明涉及新的水杨酸衍生物及其在用于护肤的化妆品和/或皮肤病学组合物中的用途，特别是用于抵抗皮肤老化的迹象和/或改善肤色的光泽度和/或 平滑面部和/或身体皮肤和/或治疗皮肤上的皱纹和细纹和/或刺激表皮更新过程。
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