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1.发明授权公开(公告)号：US08044037B2
公开(公告)日：2011-10-25
申请号：US12385614
申请日：2009-04-14
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中向前体磷酸钙化合物的悬浮液中加入偕 - 二膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 该化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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2.发明授权公开(公告)号：US07521436B2
公开(公告)日：2009-04-21
申请号：US10506550
申请日：2003-02-18
申请人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jérôme Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 本发明涉及由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中将前体磷酸钙化合物的悬浮液中加入偕 - 双膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 所述化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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3.发明申请公开(公告)号：US20090203648A1
公开(公告)日：2009-08-13
申请号：US12385614
申请日：2009-04-14
申请人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
IPC分类号： A61K31/675 , C07F9/06 , C07F9/58 , C07F9/6506 , A61K31/661 , A61P19/10
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中向前体磷酸钙化合物的悬浮液中加入偕 - 二膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 该化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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4.发明申请公开(公告)号：US20050282783A1
公开(公告)日：2005-12-22
申请号：US10506550
申请日：2003-02-18
申请人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
发明人： Bruno Bujoli , Solen Josse , Jerome Guicheux , Pascal Janvier , Jean-Michel Bouler , Guy Daculsi
IPC分类号： A61K9/06 , A61K31/663 , A61K33/42 , A61K47/36 , A61K47/38 , A61L27/12 , A61L27/54 , A61P19/10 , A61P35/00 , C07F9/38 , C07F9/6506 , A61K31/675
CPC分类号： A61L27/12 , A61L27/54 , A61L2300/216 , A61L2300/432 , A61L2300/602
摘要： The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.
摘要翻译： 本发明涉及由双膦酸或其一种盐改性的磷酸化合物，其制备方法以及其用于制备可注射组合物的用途。 修饰的磷酸钙化合物通过在超纯水中将前体磷酸钙化合物的悬浮液中加入偕 - 双膦酸或其碱金属或碱土金属盐，同时在室温下搅拌反应介质，然后通过 离心形成的化合物。 所述化合物可用于制备可注射组合物，用于治疗骨重塑平衡。
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