公开(公告)号：US06462219B2

公开(公告)日：2002-10-08

申请号：US09764549

申请日：2001-01-17

申请人： Bruno Burdet ,  August Ruettimann ,  Johann Riegl

发明人： Bruno Burdet ,  August Ruettimann ,  Johann Riegl

IPC分类号： C07C25500

CPC分类号： C07C253/30 ,  Y02P20/582 ,  C07C255/16

摘要： A process for the production of 3-hydroxypropionitrile is provided. This process includes (a) reacting acrylonitrile with water at a defined molar ratio in the presence of a weak base under specific temperature and pressure conditions until a conversion in the range of about 40% to about 80% has been achieved; (b) after cooling the mixture obtained in (a), separating off its aqueous phase; (c) distilling off the acrylonitrile from the organic phase remaining after (b); (d) subjecting the mixture obtained in (c) to pyrolysis at specific temperature and pressure conditions in the presence of a basic catalyst to obtain a mixture consisting mainly of 3-hydroxypropionitrile and acrylonitrile; and (e) isolating the desired 3-hydroxypropionitrile by fractional distillation from the mixture obtained in (d). Such a process in which the basic aqueous phase and the acrylonitrile that has been distilled off are recycled represents a preferred embodiment.

公开(公告)号：US5892058A

公开(公告)日：1999-04-06

申请号：US848041

申请日：1997-04-28

申请人： Konrad Bruggemann ,  Juan Ramon Herguijuela ,  Thomas Netscher ,  Johann Riegl

发明人： Konrad Bruggemann ,  Juan Ramon Herguijuela ,  Thomas Netscher ,  Johann Riegl

IPC分类号： B01J21/02 ,  C07B61/00 ,  C07D311/72 ,  C07D311/04

CPC分类号： C07D311/72 ,  Y02P20/582

摘要： A method of producing .alpha.-tocopherol from non-.alpha.-tocopherols is disclosed. In the disclosed method, non-.alpha.-tocopherols are hydroxymethylated and reduced to .alpha.-tocopherol in a single step by reacting formaldehyde or a formaldehyde-producing compound with the non-.alpha.-tocopherol under catalytic reducing conditions in a reaction mixture containing the non-.alpha.-tocopherol, formaldehyde or formaldehyde-producing compound and boric acid or a boric acid-producing compound dispersed in a solvent of an azeotropic mixture of trimethyl borate and methanol and a non-polar organic solvent.

摘要翻译： 公开了一种从非α-生育酚生产α-生育酚的方法。 在所公开的方法中，非α-生育酚被羟甲基化并在一个步骤中通过使甲醛或产生甲醛的化合物与非α-生育酚在催化还原条件下在含有非α-生育酚的反应混合物中反应而被还原成α-生育酚， α-生育酚，甲醛或生产甲醛的化合物和分散在硼酸三甲酯和甲醇和非极性有机溶剂的共沸混合物的溶剂中的硼酸或硼酸生成化合物。