专利检索 ap:("Bryan Irving" OR "Henry Chiu" OR "Heather Maecker" OR "Sanjeev Mariathasan" OR "Sophie M. Lehar" OR "Yan Wu" OR "Jeanne Cheung") AND inv:"Heather Maecker" 第 1 页

1.

发明申请
ANTI-PD-L1 ANTIBODIES AND ARTICLES OF MANUFACTURE 审中-公开

公开(公告)号：US20130045202A1

公开(公告)日：2013-02-21

申请号：US13479470

申请日：2012-05-24

申请人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

IPC分类号： C07K16/28 , A61P35/00 , A61P31/12 , A61K39/395 , A61P37/04

CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/489 , Y02A50/492 , A61K2300/00

摘要： The present application relates to anti-PD-L1 antibodies, which have therapeutic use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

2.

发明申请
METHODS OF USING ANTI-PD-L1 ANTIBODIES AND THEIR USE TO TREAT INFECTION RESULTING FROM T-CELL DYSFUNCTION 审中-公开
标题翻译：使用抗PD-L1抗体的方法及其用于治疗由T细胞功能丧失的感染

公开(公告)号：US20130045200A1

公开(公告)日：2013-02-21

申请号：US13478421

申请日：2012-05-23

申请人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

IPC分类号： A61K39/395 , A61P31/00 , A61P31/12 , A61P37/00

CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/489 , Y02A50/492 , A61K2300/00

摘要： The present application relates to methods of using anti-PD-L1 antibodies to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

摘要翻译： 本申请涉及使用抗PD-L1抗体来增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍（包括感染（例如急性和慢性））和肿瘤免疫的方法。

3.

发明授权
Anti-PD-L1 antibodies, compositions and articles of manufacture 有权
标题翻译：抗PD-L1抗体，组合物和制品

公开(公告)号：US08217149B2

公开(公告)日：2012-07-10

申请号：US12633339

申请日：2009-12-08

申请人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

IPC分类号： C07K16/00

CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/492 , A61K2300/00

摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

摘要翻译： 本申请涉及抗PD-L1抗体，编码它的核酸，其治疗组合物及其用途增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍性疾病，包括感染（例如急性和慢性）和肿瘤免疫。

4.

发明申请
ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION 有权
标题翻译：抗PD-L1抗体及其用于增强T细胞功能的用途

公开(公告)号：US20100203056A1

公开(公告)日：2010-08-12

申请号：US12633339

申请日：2009-12-08

申请人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

发明人： Bryan Irving , Henry Chiu , Heather Maecker , Sanjeev Mariathasan , Sophie M. Lehar , Yan Wu , Jeanne Cheung

IPC分类号： A61K39/395 , A61K38/16 , C07K16/00 , C07H21/04 , A61P33/02 , A61P31/12 , A61P35/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12P21/06

CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/492 , A61K2300/00

摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

摘要翻译： 本申请涉及抗PD-L1抗体，编码它的核酸，其治疗组合物及其用途增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍性疾病，包括感染（例如急性和慢性）和肿瘤免疫。

5.

发明授权
Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors 有权

公开(公告)号：US09724413B2

公开(公告)日：2017-08-08

申请号：US14236064

申请日：2012-08-01

申请人： Heather Maecker , Bryan Irving

发明人： Heather Maecker , Bryan Irving

IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , A61K31/4184 , A61K31/4355 , A61K31/44 , A61K31/4523 , A61K31/519 , A61K47/48 , A61K39/00

CPC分类号： A61K39/39558 , A61K31/4184 , A61K31/4355 , A61K31/44 , A61K31/4523 , A61K31/519 , A61K47/62 , A61K47/64 , A61K2039/505 , C07K16/2827 , C07K16/3046 , C07K16/3053 , A61K2300/00

摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

6.

发明申请
METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS 审中-公开
标题翻译：使用PD-1轴结合拮抗剂和MEK抑制剂治疗癌症的方法

公开(公告)号：US20140341902A1

公开(公告)日：2014-11-20

申请号：US14236064

申请日：2012-08-01

申请人： Heather Maecker , Bryan Irving

发明人： Heather Maecker , Bryan Irving

IPC分类号： A61K39/395 , A61K47/48 , A61K31/519 , A61K31/4355 , A61K31/44 , A61K31/4184 , A61K31/4523

CPC分类号： A61K39/39558 , A61K31/4184 , A61K31/4355 , A61K31/44 , A61K31/4523 , A61K31/519 , A61K47/62 , A61K47/64 , A61K2039/505 , C07K16/2827 , C07K16/3046 , C07K16/3053 , A61K2300/00

摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

摘要翻译： 本发明描述了包含PD-1轴结合拮抗剂和MEK抑制剂的组合治疗剂及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加用于治疗癌症的肿瘤免疫原性。

7.

发明申请
Methods and Compositions for Modulating Tweak and Fn14 Activity 审中-公开
标题翻译：调节调节和Fn14活动的方法和组合

公开(公告)号：US20080286271A1

公开(公告)日：2008-11-20

申请号：US11908074

申请日：2006-03-02

申请人： Avi J. Ashkenazi , Heather Maecker

发明人： Avi J. Ashkenazi , Heather Maecker

IPC分类号： A61K39/395 , C12N5/06 , A61K39/44 , A61K38/17 , A61P37/00

CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K16/2878 , C07K2319/30

摘要： Agonists and antagonists which modulate the activity of TWEAK and TWEAK receptor are provided. The methods, compositions and kits of the invention may be employed in the treatment of disorders such as cancer and immune-related diseases.

摘要翻译： 提供调节TWEAK和TWEAK受体活性的激动剂和拮抗剂。本发明的方法，组合物和试剂盒可用于治疗疾病如癌症和免疫相关疾病。

8.

发明申请
METHODS AND COMPOSITIONS FOR MODULATING TWEAK AND FN14 ACTIVITY 审中-公开
标题翻译：调节TWEAK和FN14活性的方法和组合物

公开(公告)号：US20120269808A1

公开(公告)日：2012-10-25

申请号：US13300897

申请日：2011-11-21

申请人： AVI J. ASHKENAZI , Heather Maecker

发明人： AVI J. ASHKENAZI , Heather Maecker

IPC分类号： A61K39/395 , A61P35/00 , A61P37/04 , A61N5/10 , A61P1/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61K38/19 , A61P37/06

CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K16/2878 , C07K2319/30

摘要： Agonists and antagonists which modulate the activity of TWEAK and TWEAK receptor are provided. The methods, compositions and kits of the invention may be employed in the treatment of disorders such as cancer and immune-related diseases.

摘要翻译： 提供调节TWEAK和TWEAK受体活性的激动剂和拮抗剂。本发明的方法，组合物和试剂盒可用于治疗疾病如癌症和免疫相关疾病。

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