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公开(公告)号：US06949590B2
公开(公告)日：2005-09-27
申请号：US10339777
申请日：2003-01-09
CPC分类号： C08F8/14 , C08F8/30 , C08F2810/20 , Y10S522/904 , Y10S522/905 , C08F16/06 , C08F8/32
摘要： In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.
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公开(公告)号：US07300962B2
公开(公告)日：2007-11-27
申请号：US11199613
申请日：2005-08-09
IPC分类号： C08J3/03
CPC分类号： C08F8/14 , C08F8/30 , C08F2810/20 , Y10S522/904 , Y10S522/905 , C08F16/06 , C08F8/32
摘要： In one aspect, the present invention provides hydrogels comprising polymer molecules and bridging molecules, wherein substantially all the polymer molecules are cross-linked by hydrogen bonds between polymer molecules and bridging molecules, wherein each bridging molecule is linked to at least two polymer molecules, and wherein there are substantially no covalent linkages between the polymer molecules. In some embodiments, the polymer molecules are poly(vinyl alcohol) (PVA) and the bridging molecules are amino acids. Some embodiments of the invention provide devices comprising hydrogels, and pharmaceutical compositions comprising biologically active molecules within hydrogels. Another aspect provides methods for forming hydrogels of the invention.
摘要翻译： 在一个方面，本发明提供了包含聚合物分子和桥接分子的水凝胶，其中基本上所有的聚合物分子通过聚合物分子和桥连分子之间的氢键交联，其中每个桥连分子与至少两个聚合物分子连接，以及 其中聚合物分子之间基本上没有共价键。 在一些实施方案中，聚合物分子是聚（乙烯醇）（PVA），桥连分子是氨基酸。 本发明的一些实施方案提供了包含水凝胶的装置和包含水凝胶内的生物活性分子的药物组合物。 另一方面提供了用于形成本发明的水凝胶的方法。
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3.发明授权Porous structures useful for growing living tissue, and methods of manufacture 失效用于生长生物体组织的多孔结构及其制造方法公开(公告)号：US07105580B2
公开(公告)日：2006-09-12
申请号：US10314453
申请日：2002-12-05
申请人： Prabha D. Nair , Buddy D. Ratner , Viola Vogel , Robert M. Nerem
发明人： Prabha D. Nair , Buddy D. Ratner , Viola Vogel , Robert M. Nerem
摘要： In one aspect the present invention provides biodegradable, porous structures that each include a structural framework, wherein the structural framework includes: (a) a solidified mixture of polymer molecules and amino acid molecules, wherein at least some of the amino acid molecules are linked to other amino acid molecules within the framework; and (b) a multiplicity of interconnected spaces defined by the structural framework. In some embodiments, the porous structures of the invention are adapted to physically support the growth of living cells in vitro or in vivo, and can be used to grow living tissue and/or living organs. The present invention also provide methods for making the biodegradable, porous structures of the invention.
摘要翻译： 在一个方面，本发明提供了可生物降解的多孔结构，其各自包括结构框架，其中所述结构框架包括：（a）聚合物分子和氨基酸分子的固化混合物，其中至少一些所述氨基酸分子连接到 框架内的其他氨基酸分子; 和（b）由结构框架定义的多个互连空间。 在一些实施方案中，本发明的多孔结构适于在体外或体内物理支持活细胞的生长，并且可用于生长活组织和/或活体器官。 本发明还提供了制造本发明的可生物降解的多孔结构的方法。
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