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1.发明授权Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same 有权预测肺癌复发风险的方法，以及组合物，试剂盒和微阵列公开(公告)号：US07585634B2
公开(公告)日：2009-09-08
申请号：US11971585
申请日：2008-01-09
申请人： Byung-chul Kim , Jhin-gook Kim , Nam Hur , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
发明人： Byung-chul Kim , Jhin-gook Kim , Nam Hur , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
CPC分类号： C40B40/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C40B30/04 , Y10S977/792
摘要： Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.
摘要翻译： 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。
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2.发明申请METHOD OF PREDICTING RISK OF LUNG CANCER RECURRENCE, AND A COMPOSITION, KIT AND MICROARRAY FOR THE SAME 审中-公开预测肺癌复发风险的方法及其组合物，包装及其微生物公开(公告)号：US20090291853A1
公开(公告)日：2009-11-26
申请号：US12512401
申请日：2009-07-30
申请人： Byung-Chul Kim , Jhin-gook Kim , Nam Hur , Kyu-Sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
发明人： Byung-Chul Kim , Jhin-gook Kim , Nam Hur , Kyu-Sang Lee , Dae-soon Son , Kyung-hee Park , Tae-jin Ahn
CPC分类号： C40B40/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C40B30/04 , Y10S977/792
摘要： Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.
摘要翻译： 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。
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公开(公告)号：US20100169107A1
公开(公告)日：2010-07-01
申请号：US12623893
申请日：2009-11-23
申请人： Tae-jin Ahn , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park
发明人： Tae-jin Ahn , Kyu-sang Lee , Dae-soon Son , Kyung-hee Park
摘要： Provided are a method and an apparatus for managing data indicating personal genome data. The method includes obtaining property information of a first personal genome data, which indicates genome information of an individual, by analyzing a first personal genome data, and generating integrated data by integrating the first personal genome data and a second personal genome data indicating genome data of the individual based on the obtained property information.
摘要翻译： 提供了一种用于管理表示个人基因组数据的数据的方法和装置。 该方法包括：通过分析第一个人基因组数据来获得指示个体的基因组信息的第一个人基因组数据的属性信息，以及通过整合第一个人基因组数据和指示基因组数据的第二个人基因组数据来生成综合数据 个人基于获得的财产信息。
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4.发明申请Genetic polymorphisms associated with myocardial infarction and uses thereof 审中-公开与心肌梗塞相关的遗传多态性及其用途公开(公告)号：US20060257913A1
公开(公告)日：2006-11-16
申请号：US11430939
申请日：2006-05-10
申请人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
发明人： Byung-chul Kim , Yeon-Su Lee , Min-sun Kim , Ok-kyoung Son , Moon-sue Lee , Ki-eun Kim , Ok-ryul Song , Hyo-jeong Jeon , Kyung-Hee Park , Tae-jin Ahn , Jae-Heup Kim
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including one of the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction.
摘要翻译： 提供与心肌梗死相关的遗传多态性。 更具体地，提供了包括与心肌梗死相关的单核苷酸多态性（SNP），与多核苷酸杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体，微阵列和包含一个 的多核苷酸，心肌梗死诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。
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5.发明申请Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法公开(公告)号：US20060263815A1
公开(公告)日：2006-11-23
申请号：US11435662
申请日：2006-05-17
申请人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
发明人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
摘要翻译： 提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。 此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。
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6.发明授权Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法公开(公告)号：US07732139B2
公开(公告)日：2010-06-08
申请号：US11435662
申请日：2006-05-17
申请人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
发明人： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
摘要翻译： 提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。 此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。
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7.发明授权Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene 失效乳腺癌相关蛋白，编码相同的基因，以及使用蛋白质和基因诊断乳腺癌的方法公开(公告)号：US07666603B2
公开(公告)日：2010-02-23
申请号：US12333410
申请日：2008-12-12
申请人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
发明人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
IPC分类号： C12Q1/68
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided.
摘要翻译： 提供了具有SEQ ID No.4的氨基酸序列并且具有诱导细胞凋亡的活性的分离的蛋白质和编码该蛋白质的基因。 另外，提供了具有固定基因或其片段的底物的微阵列。 此外，提供了使用特异性结合蛋白质的抗体诊断乳腺癌的方法和通过确定该基因是否在细胞中表达来诊断乳腺癌的方法。
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8.发明申请Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法公开(公告)号：US20060183139A1
公开(公告)日：2006-08-17
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译： 提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列并且包含101
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9.发明授权Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法公开(公告)号：US07833710B2
公开(公告)日：2010-11-16
申请号：US11329299
申请日：2006-01-10
申请人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
发明人： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
摘要翻译： 提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含第101位的核苷酸 核苷酸序列或其互补多核苷酸。
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10.发明申请Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene 审中-公开乳腺癌相关蛋白，编码相同的基因，以及使用蛋白质和基因诊断乳腺癌的方法公开(公告)号：US20050186610A1
公开(公告)日：2005-08-25
申请号：US11061694
申请日：2005-02-18
申请人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
发明人： Yeon-su Lee , Kyung-hee Park , Tae-jin Ahn , Jong-hoon Park
IPC分类号： G01N33/53 , C07H21/04 , C07K14/47 , C07K14/82 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/574 , G01N37/00 , C07K16/30
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided.
摘要翻译： 提供了具有SEQ ID No.4的氨基酸序列并且具有诱导细胞凋亡的活性的分离的蛋白质和编码该蛋白质的基因。 另外，提供了具有固定基因或其片段的底物的微阵列。 此外，提供了使用特异性结合蛋白质的抗体诊断乳腺癌的方法和通过确定该基因是否在细胞中表达来诊断乳腺癌的方法。
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