公开(公告)号：US20050161323A1

公开(公告)日：2005-07-28

申请号：US10514236

申请日：2002-10-04

申请人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Mi-Joong Kwon

发明人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Mi-Joong Kwon

IPC分类号： C12Q1/26 ,  C12Q1/00 ,  G01N33/487 ,  G01N27/26

CPC分类号： C12Q1/001 ,  G01N27/3272

摘要： Disclosed is a biosensor for quantifying a specific substance contained in a biological sample comprising: an electrically insulating base plate; a plurality of lead terminals formed on the base plate; a plurality of lead wires connected to the lead terminals, respectively; an electrode system including two working electrodes and one reference electrode connected to the lead wires, respectively; an insulating layer for insulating the electrodes; an enzyme reaction layer formed on the insulating layer and the electrodes; a spacer formed on the enzyme reaction layer so as to ensure a sufficient space for receiving a sample; and a cover formed on the spacer, wherein the spacer has a sample introduction port opened at one side of the spacer, and the cover has at least one slit for venting air existing in a sample receiving space defined by the spacer and the cover, the slit extending to above the electrodes from one end of the cover.

摘要翻译： 公开了一种用于定量生物样品中所含特定物质的生物传感器，包括：电绝缘基板; 形成在所述基板上的多个引线端子; 多个引线分别连接到引线端子; 电极系统，分别包括连接到引线的两个工作电极和一个参考电极; 用于绝缘电极的绝缘层; 在所述绝缘层和所述电极上形成的酶反应层; 在酶反应层上形成间隔物，以确保足够的空间用于接收样品; 以及形成在所述间隔件上的盖，其中所述间隔件具有在所述间隔件的一侧开口的样品引入口，并且所述盖具有至少一个狭缝，用于排出存在于由所述间隔件和所述盖限定的样品容纳空间中的空气， 狭缝从盖的一端延伸到电极的上方。

公开(公告)号：US07070680B2

公开(公告)日：2006-07-04

申请号：US10514236

申请日：2002-10-04

申请人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Mi-Joong Kwon

发明人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Mi-Joong Kwon

IPC分类号： G01N27/327

CPC分类号： C12Q1/001 ,  G01N27/3272

摘要： A biosensor for quantifying a specific substance contained in a biological sample includes an electrically insulating base plate, a plurality of lead terminals formed on the base plate, a plurality of lead wires connected to the lead terminals, respectively, an electrode system including two working electrodes and one reference electrode connected to the lead wires, respectively, an insulating layer that insulates the electrodes, an enzyme reaction layer formed on the insulating layer and the electrodes, a spacer formed on the enzyme reaction layer so as to ensure a sufficient space that receives a sample, and a cover formed on the spacer. Further, the spacer has a sample introduction port opened at one side of the spacer, the cover has at least one slit for venting air existing in a sample receiving space defined by the spacer and the cover, and the slit extends to above the electrodes from one end of the cover.

摘要翻译： 用于量化生物样品中所含特定物质的生物传感器包括电绝缘基板，形成在基板上的多个引线端子，分别与引线端子连接的多根引线，包括两个工作电极的电极系统 和分别连接到引线的一个参考电极，使电极绝缘的绝缘层，形成在绝缘层上的酶反应层和电极，在酶反应层上形成的间隔物，以确保接收到足够的空间 样品和形成在间隔物上的盖。 此外，间隔件具有在间隔件的一侧开口的样品引入口，盖具有至少一个用于排出存在于由间隔件和盖限定的样品容纳空间中的空气的狭缝，并且狭缝延伸到电极上方 封面的一端。

公开(公告)号：US20060163086A1

公开(公告)日：2006-07-27

申请号：US10528187

申请日：2002-10-04

申请人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Won-Dong Kim ,  Jung-Shik Song ,  Jin-A Yoo

发明人： Byung-Woo Bae ,  Heon-Kwon Lee ,  Sung-Dong Lee ,  Won-Dong Kim ,  Jung-Shik Song ,  Jin-A Yoo

IPC分类号： C25C3/02 ,  G01N33/487 ,  G01N27/26

CPC分类号： G01N27/3274 ,  G01N27/3273

摘要： Disclosed are an apparatus and a method for determining whether or not a biosensor comprising two working electrodes and one reference electrode is well manufactured, and for rapidly and accurately quantifying a specific substance contained in a biological sample. The method comprises the steps of: sequentially supplying the respective working electrodes with power supply voltage; sequentially detecting the amounts of current flowing in the respective working electrodes by virtue of the supplied power supply voltage; re-supplying the two working electrodes with power supply voltage after a predetermined time to redetect the amounts of current flowing in the respective working electrodes; reading concentrations corresponding to the amounts of current detected from a memory, and calculating an average value from the read concentrations; and checking whether or not the concentrations read from memory are within a predetermined critical range to display an error message or the calculated average value.

摘要翻译： 公开了一种用于确定包括两个工作电极和一个参比电极的生物传感器是否被良好地制造并且用于快速和准确地定量生物样品中包含的特定物质的装置和方法。 该方法包括以下步骤：向相应的工作电极依次提供电源电压; 通过提供的电源电压依次检测在各个工作电极中流动的电流量; 在预定时间之后将两个工作电极重新供给电源电压以重新检测在各个工作电极中流动的电流量; 读取与存储器检测到的电流量相对应的浓度，并根据读取的浓度计算平均值; 并且检查从存储器读取的浓度是否在预定的临界范围内，以显示错误消息或所计算的平均值。

公开(公告)号：US07297248B2

公开(公告)日：2007-11-20

申请号：US10481406

申请日：2001-10-10

申请人： Byung-Woo Bae ,  Byung-Soo Kang ,  Seong-Gi Park ,  Seong-Dong Lee ,  Mi-Joong Kwon

发明人： Byung-Woo Bae ,  Byung-Soo Kang ,  Seong-Gi Park ,  Seong-Dong Lee ,  Mi-Joong Kwon

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  G01N33/66

摘要： Disclosed is a disposable glucose strip sensor configured to rapidly and conveniently measure the concentration of glucose in blood and a glucose measurement method using the glucose strip sensor. In the glucose strip sensor, at least one checking electrodes are additionally provided at an electrode section including an operating electrode and a counter electrode. The checking electrode serves to check whether or not it is electrically connected with the counter electrode, upon measuring the concentration of glucose in a blood sample introduced in the sensor. Where two checking electrodes are provided, it may be checked whether or not an electrical connection is established between those checking electrodes. Based on the result of the checking, it is possible to determine whether or not a sufficient amount of blood sample is filled in the sensor. Accordingly, the measurement of glucose concentration can be accurately achieved.

摘要翻译： 公开了一种一次性葡萄糖条传感器，其被配置为快速且方便地测量血液中葡萄糖的浓度和使用葡萄糖条带传感器的葡萄糖测量方法。 在葡萄糖条传感器中，在包括操作电极和对电极的电极部分附加地设置至少一个检查电极。 检测电极用于在测量引入传感器的血液样本中的葡萄糖浓度时，检查其是否与对电极电连接。 在设置两个检查电极的情况下，可以检查在这些检查电极之间是否建立电连接。 基于检查结果，可以确定传感器中是否填充有足够量的血样。 因此，可以准确地实现葡萄糖浓度的测定。