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12 条记录 (耗时 0.039 秒)

    MODULATION OF TRANSTHYRETIN EXPRESSION FOR THE TREATMENT OF CNS RELATED DISORDERS
    2.
    发明申请
    MODULATION OF TRANSTHYRETIN EXPRESSION FOR THE TREATMENT OF CNS RELATED DISORDERS 审中-公开
    用于治疗CNS相关疾病的TRANSTHYRETIN表达调控

    公开(公告)号：US20110237646A1

    公开(公告)日：2011-09-29

    申请号：US13056295

    申请日：2009-08-07

    申请人： Richard Alan Smith ,  Brett P. Monia

    发明人： Richard Alan Smith ,  Brett P. Monia

    IPC分类号： A61K31/7088 ,  A61K31/7125 ,  A61K31/712 ,  A61K31/7115 ,  A61P25/00 ,  A61P25/28

    CPC分类号： A61K31/7125

    摘要： Compounds, compositions and methods are provided for modulating the expression of transthyretin in the brain, specifically the choroid plexus. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节脑中转甲状腺激素的表达，特别是脉络丛。 组合物包含针对核酸编码转甲状腺素蛋白的寡核苷酸。 提供了使用这些化合物调节转甲状腺素蛋白表达和用于诊断和治疗与转甲状腺素蛋白表达相关的疾病和病症的方法。

    System and method of sensor installation validation
    3.
    发明授权
    System and method of sensor installation validation 有权
    传感器安装验证的系统和方法

    公开(公告)号：US08731864B2

    公开(公告)日：2014-05-20

    申请号：US13105022

    申请日：2011-05-11

    申请人： Richard Alan Smith

    发明人： Richard Alan Smith

    IPC分类号： G01D3/036 ,  G01B13/00 ,  G01B13/04

    CPC分类号： G01B13/00 ,  G01B13/04 ,  G08B13/00 ,  G08B29/18

    摘要： A glassbreak detector or motion detector includes circuitry responsive to an installation process. Data concerning the installation process can be automatically stored in non-volatile memory. The stored data can be retrieved as part of an after-installation review.

    摘要翻译： 玻璃破碎探测器或运动检测器包括响应于安装过程的电路。 有关安装过程的数据可以自动存储在非易失性存储器中。 存储的数据可以作为安装后审查的一部分进行检索。

    Highly Directional Glassbreak Detector
    4.
    发明申请
    Highly Directional Glassbreak Detector 有权
    高精度玻璃破碎探测器

    公开(公告)号：US20120288102A1

    公开(公告)日：2012-11-15

    申请号：US13105026

    申请日：2011-05-11

    申请人： Richard Alan Smith

    发明人： Richard Alan Smith

    IPC分类号： H04R29/00

    CPC分类号： G08B13/04

    摘要： A glassbreak detector first and second different audio transducers. One transducer is omnidirectional. The other is highly directional. Control circuitry processes signals from both transducers and determines if a glassbreakage profile is present.

    摘要翻译： 玻璃破碎探测器第一和第二不同的音频换能器。 一个传感器是全向的。 另一个是高度定向的。 控制电路处理来自两个传感器的信号，并确定是否存在玻璃破碎轮廓。

    System and Method for Testing and Calibrating Audio Detector and Other Sensing and Communications Devices
    7.
    发明申请
    System and Method for Testing and Calibrating Audio Detector and Other Sensing and Communications Devices 审中-公开
    用于测试和校准音频检测器和其他传感和通信设备的系统和方法

    公开(公告)号：US20130076506A1

    公开(公告)日：2013-03-28

    申请号：US13241715

    申请日：2011-09-23

    申请人： Richard Alan Smith ,  Kevin G. Piel ,  John M. Kovach

    发明人： Richard Alan Smith ,  Kevin G. Piel ,  John M. Kovach

    IPC分类号： G08B29/00

    CPC分类号： G08B29/22 ,  G08B13/04 ,  G08B13/19 ,  G08B17/10

    摘要： A glass break detector can be tested using a smart phone and a downloaded test application. The recommended test procedure can be implemented by interacting with the phone and the executing application. The phone can emit a selected audio test signal to which the detector can respond. Advantageously, the installer does not need to read a test procedure from a manual and does not need to use a special test tool.

    摘要翻译： 玻璃破裂探测器可以使用智能手机和下载的测试应用进行测试。 推荐的测试程序可以通过与手机和执行应用程序交互来实现。 手机可以发出检测器可以响应的所选音频测试信号。 有利地，安装者不需要从手册中读取测试程序，并且不需要使用特殊的测试工具。

    Reduced size catheter tip measurement device
    8.
    发明授权
    Reduced size catheter tip measurement device 失效
    减小尺寸导管尖端测量装置

    公开(公告)号：US5902248A

    公开(公告)日：1999-05-11

    申请号：US744478

    申请日：1996-11-06

    申请人： Huntly D. Millar ,  Richard Alan Smith

    发明人： Huntly D. Millar ,  Richard Alan Smith

    IPC分类号： A61B8/12 ,  A61B5/02

    CPC分类号： A61M25/00 ,  A61B8/12 ,  A61B8/445 ,  A61M2025/0002

    摘要： A device that contemplates a unique and advantageous reduced size catheter tip measurement device. By using a bottom support member and a thin outer insulating layer, rather than a tubular metal casing, to support and isolate the electrical measurement sensor, the present invention drastically reduces feature size possible with current structures for catheter tip measurement devices. More specifically, the device contemplates a reduced size catheter tip pressure transducer device. The device includes a catheter body that has a support member attached to its distal tip. The support member has a support surface for a semiconductor pressures sensor that provides mechanical stability to the pressure sensor. The exposed electrical and metal areas of the device are insulated from surrounding tissues and fluids by an outer insulating layer, which is preferably a polyimide sleeve. Utilizing the device catheter tip pressure transducers may be constructed having approximately half the current volume size of prior devices. This drastic reduction is size allows for placement inside small diameter lumens of catheters, small diameter veins and arteries, or other small biological features that have up to now been too small for high-fidelity measurements by prior catheter tip pressure transducers.

    摘要翻译： 一种考虑独特且有利的减小尺寸的导管尖端测量装置的装置。 通过使用底部支撑构件和薄的外部绝缘层而不是管状金属壳体来支撑和隔离电气测量传感器，本发明大大减小了用于导管尖端测量装置的当前结构可能的特征尺寸。 更具体地，该装置考虑了减小尺寸的导管尖端压力传感器装置。 该装置包括具有附接到其远侧末端的支撑构件的导管主体。 支撑构件具有用于为压力传感器提供机械稳定性的半导体压力传感器的支撑表面。 设备的暴露的电和金属区域通过外部绝缘层与周围的组织和流体绝缘，该绝缘层优选为聚酰亚胺套管。 利用装置导管尖端压力传感器可以构造成具有大约现有装置的当前体积大小的一半。 这种急剧减小的尺寸允许放置在小直径的导管内腔，小直径的静脉和动脉内，或其它小的生物学特征，其迄今为止太小以致于现有的导管尖端压力传感器的高保真度测量。

    Highly directional glassbreak detector
    9.
    发明授权
    Highly directional glassbreak detector 有权

    公开(公告)号：US09697707B2

    公开(公告)日：2017-07-04

    申请号：US13105026

    申请日：2011-05-11

    申请人： Richard Alan Smith

    发明人： Richard Alan Smith

    IPC分类号： G08B13/00 ,  G08B13/04

    CPC分类号： G08B13/04

    摘要： A glassbreak detector includes first and second different audio transducers. The first transducer is omnidirectional. The second transducer is highly directional. Control circuitry processes signals from both of the first and second transducers and determines if a glassbreakage profile is present.

    Method and System for Audio Detector Mode Activation
    10.
    发明申请
    Method and System for Audio Detector Mode Activation 审中-公开
    音频检测器模式激活的方法和系统

    公开(公告)号：US20130170323A1

    公开(公告)日：2013-07-04

    申请号：US13342387

    申请日：2012-01-03

    申请人： Richard Alan Smith

    发明人： Richard Alan Smith

    IPC分类号： G10K11/00

    CPC分类号： G08B13/04 ,  G08B29/14

    摘要： An acoustic detector comprises an acoustic sensor for receiving an acoustic signal. The acoustic signal selectively comprises a test sound with an encoded pattern indicative of the select mode. A controller is operatively associated with the acoustic sensor for analyzing the received acoustic signal to determine if the encoded pattern is present, changing a mode of operation if the encoded pattern is present, and selectively adjusting the operation of the acoustic detector based upon the received acoustic signal if mode is changed.

    摘要翻译： 声学检测器包括用于接收声信号的声传感器。 声信号选择性地包括具有指示选择模式的编码模式的测试声音。 控制器可操作地与声传感器相关联，用于分析所接收的声信号以确定编码图案是否存在，如果编码图案存在则改变操作模式，并且基于接收的声音选择性地调节声检测器的操作 信号如果模式改变。