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1.
公开(公告)号:US20120258117A1
公开(公告)日:2012-10-11
申请号:US13440510
申请日:2012-04-05
IPC分类号: A61K39/395 , A61P35/00 , A61K31/7088 , C07H21/02 , A61K31/05 , C07K16/40 , C07C39/21 , C07H21/04 , C12N5/09 , A61K31/713
CPC分类号: A61K31/05 , A61K31/7088 , A61K31/713
摘要: Provided are methods and compositions for inhibiting mono-ubiquitination of a histone in a cell. Also provided are methods and compositions for inducing senescence in a cell. Additionally provided are methods and compositions for treatment of cancer, including glioma. In particular, these methods and compositions may include an inhibitor of a ubiquitin ligase.
摘要翻译: 提供抑制细胞中组蛋白单泛素化的方法和组合物。 还提供了用于在细胞中诱导衰老的方法和组合物。 另外提供了用于治疗癌症的方法和组合物,包括神经胶质瘤。 特别地,这些方法和组合物可以包括泛素连接酶的抑制剂。
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公开(公告)号:US20120115225A1
公开(公告)日:2012-05-10
申请号:US13265006
申请日:2010-04-22
申请人: C. W. Xu
发明人: C. W. Xu
IPC分类号: C12N5/071 , C12N5/0775
CPC分类号: C12N5/0696 , C12N2500/38 , C12N2501/065 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2502/13
摘要: Purified somatic cell reprogramming factors are described herein. The factors are particularly useful alone or in combination with at least one effector of cellular metabolism, in order to generate at least one reprogramming somatic cell. Methods for using at least one somatic cell reprogramming factor and at least one somatic cell reprogramming enhancing factor are pro-vided. Additionally, the cells generated from the methods are also described. The methods and cells may find use in personalized medicine applications.
摘要翻译: 本文描述了纯化的体细胞重编程因子。 这些因子单独或与细胞代谢的至少一种效应物组合是特别有用的,以便产生至少一种重编程体细胞。 使用至少一种体细胞重编程因子和至少一种体细胞重编程增强因子的方法。 此外,还描述了从该方法生成的单元。 方法和细胞可用于个性化医学应用。
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