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1.发明授权公开(公告)号：US08951727B2
公开(公告)日：2015-02-10
申请号：US13621735
申请日：2012-09-17
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore.
摘要翻译： 通过使纳米孔电泳驱动分子，可以实现单分子检测。 为了增强易位控制，功能化和非功能化电极被策略性地放置在纳米孔周围或上方。 通过电极检测的透射光谱和输入电压的变化允许单个分子在通过纳米孔时准确鉴定。
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2.发明授权Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device 有权使用场效应装置来识别纳米孔测序装置中的易位电荷标记分子公开(公告)号：US09090936B2
公开(公告)日：2015-07-28
申请号：US13621745
申请日：2012-09-17
IPC分类号： B82Y15/00 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer.
摘要翻译： 检测器装置包括场效应晶体管，配置为当电荷标记分子的至少一部分通过纳米孔转位时，经历源极 - 漏极电流的振幅变化。 在一些实施方案中，场效应晶体管是碳纳米管场效应晶体管，并且纳米孔位于膜中。 在其他实施方案中，场效应晶体管是碳纳米管场效应晶体管，并且纳米孔以半导体层中的纳米通道的形式实现。
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公开(公告)号：US09488636B2
公开(公告)日：2016-11-08
申请号：US14746757
申请日：2015-06-22
IPC分类号： B82Y15/00 , G01N33/487 , H01L51/05 , H01L51/00 , G01N27/414 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates through the nanopore. In some implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is located in a membrane. In other implementations, the field-effect transistor is a carbon nanotube field effect transistor and the nanopore is implemented in the form of a nano-channel in a semiconductor layer.
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公开(公告)号：US09234882B2
公开(公告)日：2016-01-12
申请号：US14576148
申请日：2014-12-18
IPC分类号： G01N33/48 , G01N33/487 , H01L51/05 , H01L51/00 , G01N27/414 , B82Y15/00 , C12Q1/68 , G01N27/447 , G01N33/18
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G01N27/4145 , G01N27/44704 , G01N33/18 , G01N33/1826 , H01L51/0048 , H01L51/055 , H01L51/0558
摘要： By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore.
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